KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders. Paradoxical, excitatory GABA signaling is usually assumed to contribute to abnormal network activity...

Full description

Bibliographic Details
Main Authors:	Marie Goutierre, Sana Al Awabdh, Florian Donneger, Emeline François, Daniel Gomez-Dominguez, Theano Irinopoulou, Liset Menendez de la Prida, Jean Christophe Poncer
Format:	Article
Language:	English
Published:	Elsevier 2019-07-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124719307594

Similar Items

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity
by: Etienne Côme, et al.
Published: (2019-02-01)

WNK3 maintains the GABAergic inhibitory tone, synaptic excitation and neuronal excitability via regulation of KCC2 cotransporter in mature neurons
by: Lim, Wee Meng, et al.
Published: (2022)

NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons
by: Erwan Pol, et al.
Published: (2023-09-01)

Kainate Receptors Coexist in a Functional Complex with KCC2 and Regulate Chloride Homeostasis in Hippocampal Neurons
by: Vivek Mahadevan, et al.
Published: (2014-06-01)

The brain-specific kinase LMTK3 regulates neuronal excitability by decreasing KCC2-dependent neuronal Cl− extrusion
by: Noell Cho, et al.
Published: (2024-04-01)

The Expanding Therapeutic Potential of Neuronal KCC2
by: Bor Luen Tang
Published: (2020-01-01)

APP modulates KCC2 expression and function in hippocampal GABAergic inhibition
by: Ming Chen, et al.
Published: (2017-01-01)

Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons
by: Anastasia Ludwig, et al.
Published: (2011-01-01)

ASTROCYTES EXERT NEGATIVE MODULATION ON HIPPOCAMPAL NEURON EXCITABILITY
by: Sara Expósito, et al.
Published: (2023-10-01)

Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing
by: Sneha Ray, et al.
Published: (2024-03-01)

DIVERGENT HIPPOCAMPAL REPRESENTATIONS UNDERLIE REFERENCE AND WORKING MEMORY PROCESSES
by: Juan P. Quintanilla, et al.
Published: (2023-10-01)

Altered neuronal excitability underlies impaired hippocampal function in an animal model of psychosis
by: Thomas eGrüter, et al.
Published: (2015-05-01)

SORAYA MEHRABI HIPPOCAMPAL CHLORIDE TRANSPORTER KCC2 CONTRIBUTES TO EXCITATORY GABA DYSREGULATION IN THE DEVELOPMENTAL RAT MODEL OF SCHIZOPHRENIA
by: Soraya Mehrabi
Published: (2023-10-01)

Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex
by: Yusuke Takezawa, et al.
Published: (2023-03-01)

TRESK CHANNEL MODULATES CA3 PYRAMIDAL NEURONS’ EXCITABILITY AND HIPPOCAMPAL SYNAPTIC PLASTICITY
by: Helena Lluís, et al.
Published: (2023-10-01)

Neuronal chloride regulation via KCC2 is modulated through a GABAB receptor protein complex
by: Wright, R, et al.
Published: (2017)

Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice
by: Jing Rong, et al.
Published: (2023-01-01)

The Effects of Diagnostic Ultrasound Waves on Excitability Threshold and Cellular Apoptosis Induced by Pentylenetetrazole in Hippocampal Neurons
by: Faezeh Shokri, et al.
Published: (2022-09-01)

EXPLORING THE ROLE OF THE WNK-SPAK-NKCC1-KCC2 PATHWAY IN THE REGULATION OF NEURONAL ACTIVITY OF THE SUPRACHIASMATIC NUCLEUS
by: Vanessa Isabel Romero Estrada, et al.
Published: (2023-10-01)

Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons
by: Francis J. Prael III, et al.
Published: (2022-06-01)

Nrf-2 modulates excitability of hippocampal neurons by regulating ferroptosis and neuroinflammation after subarachnoid hemorrhage in rats
by: Dazhao Fang, et al.
Published: (2024-02-01)

Development of KCC2 therapeutics to treat neurological disorders
by: Shilpa D. Kadam, et al.
Published: (2024-12-01)

Therapeutic potential for KCC2-targeted neurological diseases
by: Kazuo Tomita, et al.
Published: (2023-12-01)

The role of KCC2 in recovery of consciousness from anesthesia
by: Xue-Jun Song
Published: (2024-01-01)

KCC Theory of the Oregonator Model for Belousov-Zhabotinsky Reaction
by: M. K. Gupta, et al.
Published: (2023-12-01)

Silencing of Ago-2 Interacting Protein SERBP1 Relieves KCC2 Repression by miR-92 in Neurons
by: Christian Barbato, et al.
Published: (2022-03-01)

Decreased Immunoreactivities of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Kanamycin-treated Rats
by: Myung-Whan Suh, et al.
Published: (2012-09-01)

K+/Cl− cotransporter 2 (KCC2) and Na+/HCO3− cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation
by: Abhishek Pethe, et al.
Published: (2023-10-01)

NKCC1 and KCC2: Structural insights into phospho-regulation
by: Anna-Maria Hartmann, et al.
Published: (2022-07-01)

Hippocampal neurons wait their turn
by: Yuan Gao, et al.
Published: (2014-03-01)

Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice
by: Nicholas P. Vyleta, et al.
Published: (2023-03-01)

Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function
by: Min-Yi Wu, et al.
Published: (2022-01-01)

LIFU Alleviates Neuropathic Pain by Improving the KCC2 Expression and Inhibiting the CaMKIV–KCC2 Pathway in the L4–L5 Section of the Spinal Cord
by: Ye-Hui Liao, et al.
Published: (2021-01-01)

Exciting experiences make neurons less excitable
by: Prakruti Nanda, et al.
Published: (2017-07-01)

A comprehensive review of KCC-1 fibrous silica for water treatment
by: Saeed Shirazian, et al.
Published: (2025-01-01)

Socio-economic conditions of Rishi community in Khulna City Corporation (KCC)
by: Rina Aktar, et al.
Published: (2023-06-01)

VEGF PREVENTS THE AXOTOMY-INDUCED KCC2 DOWNREGULATION IN EXTRAOCULAR MOTONEURONS
by: Jaime Capilla-López, et al.
Published: (2023-10-01)

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function
by: Ru Liu, et al.
Published: (2020-01-01)

TGF-β2 Regulates Transcription of the K<sup>+</sup>/Cl<sup>−</sup> Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons
by: Anastasia Rigkou, et al.
Published: (2022-11-01)

Size of hippocampal pyramidal neurons in schizophrenia
by: Highley, JR, et al.
Published: (2004)