Changing places to study short-term effects of air pollution on cardiovascular health: a panel study
Abstract Background Short-term exposure to ambient air pollution triggers acute cardiovascular events. Here, we evaluate the association of exposure to ambient air pollution with two intermediate cardiovascular endpoints: blood pressure and carotid stiffness. Methods In a one-year panel study, we in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Environmental Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12940-018-0425-7 |
| _version_ | 1818137660181446656 |
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| author | Hans Scheers Tim S. Nawrot Benoit Nemery Lidia Casas |
| author_facet | Hans Scheers Tim S. Nawrot Benoit Nemery Lidia Casas |
| author_sort | Hans Scheers |
| collection | DOAJ |
| description | Abstract Background Short-term exposure to ambient air pollution triggers acute cardiovascular events. Here, we evaluate the association of exposure to ambient air pollution with two intermediate cardiovascular endpoints: blood pressure and carotid stiffness. Methods In a one-year panel study, we included 20 healthy volunteers (10 male-female couples aged 59–75 years) with air pollution and health parameters measured every two months at their region of residence (Leuven, Belgium) and twice during two ten-day periods in two locations, one with higher (Milan, Italy) and one with lower (Vindeln, Sweden) air pollution levels (220 observations). We measured blood pressure, carotid arterial stiffness, personal exposure to NO2, and ambient concentrations of PM10, PM2.5, and NO2. We used linear mixed models to evaluate the associations between the health outcomes and the air pollutants. Results Compared with Leuven, exposure to pollutants was higher in Milan and lower in Vindeln, with the highest contrast for NO2 (median 20.7 μg/m3 (IQR:7.4) vs 65.1 μg/m3 (9.0) and 4.5 mg/m3 (0.8), respectively). We did not observe significant associations between either systolic or diastolic blood pressure and variations in air pollution. However, we found significant associations between arterial stiffness and 5 day average exposure to the studied pollutants. The strongest associations were observed for PM10 with carotid distensibility (DC) and compliance (CC) coefficients, and the young elastic modulus (YEM): 4.3% (95%CI:7.0;1.5) increase in DC, 4.7% (95%CI:7.1;2.3) increase in CC and 4.2% (95%CI:1.1;7.3) decrease in YEM for each 10 μg/m3 decreases in PM10. Conclusions Our study suggests that short-term exposure to air pollution results in reductions in carotid elasticity among elderly population. |
| first_indexed | 2024-12-11T09:59:50Z |
| format | Article |
| id | doaj.art-e63ab53d987044f1a740fc490d51ed00 |
| institution | Directory Open Access Journal |
| issn | 1476-069X |
| language | English |
| last_indexed | 2024-12-11T09:59:50Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Environmental Health |
| spelling | doaj.art-e63ab53d987044f1a740fc490d51ed002022-12-22T01:12:10ZengBMCEnvironmental Health1476-069X2018-11-011711810.1186/s12940-018-0425-7Changing places to study short-term effects of air pollution on cardiovascular health: a panel studyHans Scheers0Tim S. Nawrot1Benoit Nemery2Lidia Casas3Environment and Health Unit, Department of Public Health and Primary Care, KU LeuvenEnvironment and Health Unit, Department of Public Health and Primary Care, KU LeuvenEnvironment and Health Unit, Department of Public Health and Primary Care, KU LeuvenEnvironment and Health Unit, Department of Public Health and Primary Care, KU LeuvenAbstract Background Short-term exposure to ambient air pollution triggers acute cardiovascular events. Here, we evaluate the association of exposure to ambient air pollution with two intermediate cardiovascular endpoints: blood pressure and carotid stiffness. Methods In a one-year panel study, we included 20 healthy volunteers (10 male-female couples aged 59–75 years) with air pollution and health parameters measured every two months at their region of residence (Leuven, Belgium) and twice during two ten-day periods in two locations, one with higher (Milan, Italy) and one with lower (Vindeln, Sweden) air pollution levels (220 observations). We measured blood pressure, carotid arterial stiffness, personal exposure to NO2, and ambient concentrations of PM10, PM2.5, and NO2. We used linear mixed models to evaluate the associations between the health outcomes and the air pollutants. Results Compared with Leuven, exposure to pollutants was higher in Milan and lower in Vindeln, with the highest contrast for NO2 (median 20.7 μg/m3 (IQR:7.4) vs 65.1 μg/m3 (9.0) and 4.5 mg/m3 (0.8), respectively). We did not observe significant associations between either systolic or diastolic blood pressure and variations in air pollution. However, we found significant associations between arterial stiffness and 5 day average exposure to the studied pollutants. The strongest associations were observed for PM10 with carotid distensibility (DC) and compliance (CC) coefficients, and the young elastic modulus (YEM): 4.3% (95%CI:7.0;1.5) increase in DC, 4.7% (95%CI:7.1;2.3) increase in CC and 4.2% (95%CI:1.1;7.3) decrease in YEM for each 10 μg/m3 decreases in PM10. Conclusions Our study suggests that short-term exposure to air pollution results in reductions in carotid elasticity among elderly population.http://link.springer.com/article/10.1186/s12940-018-0425-7Air pollutionCarotid stiffnessBlood pressureQuasi-experimental study |
| spellingShingle | Hans Scheers Tim S. Nawrot Benoit Nemery Lidia Casas Changing places to study short-term effects of air pollution on cardiovascular health: a panel study Environmental Health Air pollution Carotid stiffness Blood pressure Quasi-experimental study |
| title | Changing places to study short-term effects of air pollution on cardiovascular health: a panel study |
| title_full | Changing places to study short-term effects of air pollution on cardiovascular health: a panel study |
| title_fullStr | Changing places to study short-term effects of air pollution on cardiovascular health: a panel study |
| title_full_unstemmed | Changing places to study short-term effects of air pollution on cardiovascular health: a panel study |
| title_short | Changing places to study short-term effects of air pollution on cardiovascular health: a panel study |
| title_sort | changing places to study short term effects of air pollution on cardiovascular health a panel study |
| topic | Air pollution Carotid stiffness Blood pressure Quasi-experimental study |
| url | http://link.springer.com/article/10.1186/s12940-018-0425-7 |
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