Lipid Nanoparticles and Liposomes for Bone Diseases Treatment
Because of their outstanding biocompatibility, sufficient capacity to control drug release, and passive targeting capability, lipid nanoparticles are one of the world’s most widely utilized drug delivery systems. However, numerous disadvantages limit the use of lipid nanoparticles in clinical settin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/12/3158 |
| _version_ | 1797461319223345152 |
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| author | Alexandra-Cristina Burdușel Ecaterina Andronescu |
| author_facet | Alexandra-Cristina Burdușel Ecaterina Andronescu |
| author_sort | Alexandra-Cristina Burdușel |
| collection | DOAJ |
| description | Because of their outstanding biocompatibility, sufficient capacity to control drug release, and passive targeting capability, lipid nanoparticles are one of the world’s most widely utilized drug delivery systems. However, numerous disadvantages limit the use of lipid nanoparticles in clinical settings, especially in bone regeneration, such as challenges in transporting, storing, and maintaining drug concentration in the local area. Scaffolds are frequently employed as implants to provide mechanical support to the damaged area or as diagnostic and imaging tools. On the other hand, unmodified scaffolds have limited powers in fostering tissue regeneration and curing illnesses. Liposomes offer a solid foundation for the long-term development of various commercial solutions for the effective drug delivery-assisted treatment of medical conditions. As drug delivery vehicles in medicine, adjuvants in vaccination, signal enhancers/carriers in medical diagnostics and analytical biochemistry, solubilizers for various ingredients as well as support matrices for various ingredients, and penetration enhancers in cosmetics are just a few of the industrial applications for liposomes. This review introduces and discusses the use of lipid nanoparticles and liposomes and the application of lipid nanoparticles and liposome systems based on different active substances in bone diseases. |
| first_indexed | 2024-03-09T17:18:41Z |
| format | Article |
| id | doaj.art-e63ac2b875f142f9a1a1f8c35ac8417b |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T17:18:41Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e63ac2b875f142f9a1a1f8c35ac8417b2023-11-24T13:27:51ZengMDPI AGBiomedicines2227-90592022-12-011012315810.3390/biomedicines10123158Lipid Nanoparticles and Liposomes for Bone Diseases TreatmentAlexandra-Cristina Burdușel0Ecaterina Andronescu1Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1–7 Gheorghe Polizu Street, 011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University Politehnica of Bucharest, 1–7 Gheorghe Polizu Street, 011061 Bucharest, RomaniaBecause of their outstanding biocompatibility, sufficient capacity to control drug release, and passive targeting capability, lipid nanoparticles are one of the world’s most widely utilized drug delivery systems. However, numerous disadvantages limit the use of lipid nanoparticles in clinical settings, especially in bone regeneration, such as challenges in transporting, storing, and maintaining drug concentration in the local area. Scaffolds are frequently employed as implants to provide mechanical support to the damaged area or as diagnostic and imaging tools. On the other hand, unmodified scaffolds have limited powers in fostering tissue regeneration and curing illnesses. Liposomes offer a solid foundation for the long-term development of various commercial solutions for the effective drug delivery-assisted treatment of medical conditions. As drug delivery vehicles in medicine, adjuvants in vaccination, signal enhancers/carriers in medical diagnostics and analytical biochemistry, solubilizers for various ingredients as well as support matrices for various ingredients, and penetration enhancers in cosmetics are just a few of the industrial applications for liposomes. This review introduces and discusses the use of lipid nanoparticles and liposomes and the application of lipid nanoparticles and liposome systems based on different active substances in bone diseases.https://www.mdpi.com/2227-9059/10/12/3158lipid nanoparticlesbone diseaseliposomeosteoporosis |
| spellingShingle | Alexandra-Cristina Burdușel Ecaterina Andronescu Lipid Nanoparticles and Liposomes for Bone Diseases Treatment Biomedicines lipid nanoparticles bone disease liposome osteoporosis |
| title | Lipid Nanoparticles and Liposomes for Bone Diseases Treatment |
| title_full | Lipid Nanoparticles and Liposomes for Bone Diseases Treatment |
| title_fullStr | Lipid Nanoparticles and Liposomes for Bone Diseases Treatment |
| title_full_unstemmed | Lipid Nanoparticles and Liposomes for Bone Diseases Treatment |
| title_short | Lipid Nanoparticles and Liposomes for Bone Diseases Treatment |
| title_sort | lipid nanoparticles and liposomes for bone diseases treatment |
| topic | lipid nanoparticles bone disease liposome osteoporosis |
| url | https://www.mdpi.com/2227-9059/10/12/3158 |
| work_keys_str_mv | AT alexandracristinaburdusel lipidnanoparticlesandliposomesforbonediseasestreatment AT ecaterinaandronescu lipidnanoparticlesandliposomesforbonediseasestreatment |