Molecular mechanisms of the microRNA-132 during tumor progressions
Abstract Cancer as one of the leading causes of human deaths has always been one of the main health challenges in the world. Despite recent advances in therapeutic and diagnostic methods, there is still a high mortality rate among cancer patients. Late diagnosis is one of the main reasons for the hi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-021-02149-7 |
| _version_ | 1818600634191970304 |
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| author | Meysam Moghbeli Amir Sadra Zangouei Zahra Nasrpour Navaii Negin Taghehchian |
| author_facet | Meysam Moghbeli Amir Sadra Zangouei Zahra Nasrpour Navaii Negin Taghehchian |
| author_sort | Meysam Moghbeli |
| collection | DOAJ |
| description | Abstract Cancer as one of the leading causes of human deaths has always been one of the main health challenges in the world. Despite recent advances in therapeutic and diagnostic methods, there is still a high mortality rate among cancer patients. Late diagnosis is one of the main reasons for the high ratio of cancer related deaths. Therefore, it is required to introduce novel early detection methods. Various molecular mechanisms are associated with the tumor progression and metastasis. MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) family that has important functions in regulation of the cellular processes such as cell proliferation, apoptosis, and tumor progression. Moreover, they have higher stability in body fluids compared with mRNAs which can be introduced as non-invasive diagnostic markers in cancer patients. MiR-132 has important functions as tumor suppressor or oncogene in different cancers. In the present review, we have summarized all of the studies which have been reported the role of miR-132 during tumor progressions. We categorized the miR-132 target genes based on their cell and molecular functions. Although, it has been reported that the miR-132 mainly functions as a tumor suppressor, it has also oncogenic functions especially in pancreatic tumors. MiR-132 mainly exerts its roles during tumor progressions by regulation of the transcription factors and signaling pathways. Present review clarifies the tumor specific molecular mechanisms of miR-132 to introduce that as an efficient non-invasive diagnostic marker in various cancers. |
| first_indexed | 2024-12-16T12:38:36Z |
| format | Article |
| id | doaj.art-e63ecf18dfa6443a923b0567e3e824b9 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-16T12:38:36Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-e63ecf18dfa6443a923b0567e3e824b92022-12-21T22:31:29ZengBMCCancer Cell International1475-28672021-08-0121111110.1186/s12935-021-02149-7Molecular mechanisms of the microRNA-132 during tumor progressionsMeysam Moghbeli0Amir Sadra Zangouei1Zahra Nasrpour Navaii2Negin Taghehchian3Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical SciencesDepartment of Chemistry, Faculty of Science, Ferdowsi University of MashhadAbstract Cancer as one of the leading causes of human deaths has always been one of the main health challenges in the world. Despite recent advances in therapeutic and diagnostic methods, there is still a high mortality rate among cancer patients. Late diagnosis is one of the main reasons for the high ratio of cancer related deaths. Therefore, it is required to introduce novel early detection methods. Various molecular mechanisms are associated with the tumor progression and metastasis. MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) family that has important functions in regulation of the cellular processes such as cell proliferation, apoptosis, and tumor progression. Moreover, they have higher stability in body fluids compared with mRNAs which can be introduced as non-invasive diagnostic markers in cancer patients. MiR-132 has important functions as tumor suppressor or oncogene in different cancers. In the present review, we have summarized all of the studies which have been reported the role of miR-132 during tumor progressions. We categorized the miR-132 target genes based on their cell and molecular functions. Although, it has been reported that the miR-132 mainly functions as a tumor suppressor, it has also oncogenic functions especially in pancreatic tumors. MiR-132 mainly exerts its roles during tumor progressions by regulation of the transcription factors and signaling pathways. Present review clarifies the tumor specific molecular mechanisms of miR-132 to introduce that as an efficient non-invasive diagnostic marker in various cancers.https://doi.org/10.1186/s12935-021-02149-7MiR-132CancerDiagnosisPrognosisMarker |
| spellingShingle | Meysam Moghbeli Amir Sadra Zangouei Zahra Nasrpour Navaii Negin Taghehchian Molecular mechanisms of the microRNA-132 during tumor progressions Cancer Cell International MiR-132 Cancer Diagnosis Prognosis Marker |
| title | Molecular mechanisms of the microRNA-132 during tumor progressions |
| title_full | Molecular mechanisms of the microRNA-132 during tumor progressions |
| title_fullStr | Molecular mechanisms of the microRNA-132 during tumor progressions |
| title_full_unstemmed | Molecular mechanisms of the microRNA-132 during tumor progressions |
| title_short | Molecular mechanisms of the microRNA-132 during tumor progressions |
| title_sort | molecular mechanisms of the microrna 132 during tumor progressions |
| topic | MiR-132 Cancer Diagnosis Prognosis Marker |
| url | https://doi.org/10.1186/s12935-021-02149-7 |
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