Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients
Guohua Zhu,1,2,* Jukun Song,2,3,* Weimin Chen,3,* Dongbo Yuan,2,3 Wei Wang,2 Xiaoyue Chen,3 Hen Liu,2,4 Hao Su,2,4 Jianguo Zhu1– 4 1Guizhou Medical University, Guiyang, Guizhou Province 550002, People’s Republic of China; 2Department of Urology, Guizhou Provincial People&rsqu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-01-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/expression-and-role-of-dickkopf-1-dkk1-in-tumors-from-the-cells-to-the-peer-reviewed-article-CMAR |
| _version_ | 1818617440007880704 |
|---|---|
| author | Zhu G Song J Chen W Yuan D Wang W Chen X Liu H Su H Zhu J |
| author_facet | Zhu G Song J Chen W Yuan D Wang W Chen X Liu H Su H Zhu J |
| author_sort | Zhu G |
| collection | DOAJ |
| description | Guohua Zhu,1,2,* Jukun Song,2,3,* Weimin Chen,3,* Dongbo Yuan,2,3 Wei Wang,2 Xiaoyue Chen,3 Hen Liu,2,4 Hao Su,2,4 Jianguo Zhu1– 4 1Guizhou Medical University, Guiyang, Guizhou Province 550002, People’s Republic of China; 2Department of Urology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou Province 550002, People’s Republic of China; 3Guizhou University School of Medicine, Guiyang, Guizhou Province 550025, People’s Republic of China; 4Zunyi Medical University, Zunyi, Guizhou Province 563000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianguo ZhuDepartment of Urology, Guizhou Provincial People’s Hospital,, Guiyang, Guizhou Province 550002, People’s Republic of ChinaTel/Fax +86-851-85925503Email doctorzhujianguo@163.comAbstract: Dickkopf-1 (Dkk1) is a secretory antagonist of the classical Wnt signaling pathway. Many studies have reported that Dkk1 is abnormally expressed in tumor cells, and abnormal expression of Dkk1 can inhibit cell proliferation or induce apoptosis through pro-apoptotic factors, However, due to the differences in tumor environment and the complex regulatory mechanisms in different tumors, Dkk1 has different effects on the progression of different tumors. In many tumors, high expression of Dkk1 may promote tumor metastasis. However, Dkk1, which is highly expressed in other tumors, can inhibit tumor invasion and metastasis. More and more evidence shows that Dkk1 plays a complex and different role in tumor occurrence, development and metastasis in different tumor environments and through a variety of complex regulatory mechanisms. Therefore, Dkk1 may not only be a useful biomarker of metastasis, but also a target for studying the metabolic mechanism of tumor cells and treating tumors in many tumor types. Therefore, this article reviews the research progress on the expression, mechanism and function of Dkk1 in different tumors, and at the same time, based on the public database data, we made a further analysis of the expression of Dkk1 in different tumors.Keywords: dickkopf-1, Dkk1, Wnt signaling pathway, tumor mechanism, metastasis, biomarker, in vitro, in vivo |
| first_indexed | 2024-12-16T17:05:43Z |
| format | Article |
| id | doaj.art-e63f681616d34a518cc622c5b730b6c7 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-16T17:05:43Z |
| publishDate | 2021-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-e63f681616d34a518cc622c5b730b6c72022-12-21T22:23:35ZengDove Medical PressCancer Management and Research1179-13222021-01-01Volume 1365967561451Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the PatientsZhu GSong JChen WYuan DWang WChen XLiu HSu HZhu JGuohua Zhu,1,2,* Jukun Song,2,3,* Weimin Chen,3,* Dongbo Yuan,2,3 Wei Wang,2 Xiaoyue Chen,3 Hen Liu,2,4 Hao Su,2,4 Jianguo Zhu1– 4 1Guizhou Medical University, Guiyang, Guizhou Province 550002, People’s Republic of China; 2Department of Urology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou Province 550002, People’s Republic of China; 3Guizhou University School of Medicine, Guiyang, Guizhou Province 550025, People’s Republic of China; 4Zunyi Medical University, Zunyi, Guizhou Province 563000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianguo ZhuDepartment of Urology, Guizhou Provincial People’s Hospital,, Guiyang, Guizhou Province 550002, People’s Republic of ChinaTel/Fax +86-851-85925503Email doctorzhujianguo@163.comAbstract: Dickkopf-1 (Dkk1) is a secretory antagonist of the classical Wnt signaling pathway. Many studies have reported that Dkk1 is abnormally expressed in tumor cells, and abnormal expression of Dkk1 can inhibit cell proliferation or induce apoptosis through pro-apoptotic factors, However, due to the differences in tumor environment and the complex regulatory mechanisms in different tumors, Dkk1 has different effects on the progression of different tumors. In many tumors, high expression of Dkk1 may promote tumor metastasis. However, Dkk1, which is highly expressed in other tumors, can inhibit tumor invasion and metastasis. More and more evidence shows that Dkk1 plays a complex and different role in tumor occurrence, development and metastasis in different tumor environments and through a variety of complex regulatory mechanisms. Therefore, Dkk1 may not only be a useful biomarker of metastasis, but also a target for studying the metabolic mechanism of tumor cells and treating tumors in many tumor types. Therefore, this article reviews the research progress on the expression, mechanism and function of Dkk1 in different tumors, and at the same time, based on the public database data, we made a further analysis of the expression of Dkk1 in different tumors.Keywords: dickkopf-1, Dkk1, Wnt signaling pathway, tumor mechanism, metastasis, biomarker, in vitro, in vivohttps://www.dovepress.com/expression-and-role-of-dickkopf-1-dkk1-in-tumors-from-the-cells-to-the-peer-reviewed-article-CMARdickkopf-1 (dkk1)wnt signaling pathwaytumor mechanismmetastasisbiomarkerin vitroin vivo. |
| spellingShingle | Zhu G Song J Chen W Yuan D Wang W Chen X Liu H Su H Zhu J Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients Cancer Management and Research dickkopf-1 (dkk1) wnt signaling pathway tumor mechanism metastasis biomarker in vitro in vivo. |
| title | Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients |
| title_full | Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients |
| title_fullStr | Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients |
| title_full_unstemmed | Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients |
| title_short | Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients |
| title_sort | expression and role of dickkopf 1 dkk1 in tumors from the cells to the patients |
| topic | dickkopf-1 (dkk1) wnt signaling pathway tumor mechanism metastasis biomarker in vitro in vivo. |
| url | https://www.dovepress.com/expression-and-role-of-dickkopf-1-dkk1-in-tumors-from-the-cells-to-the-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT zhug expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients AT songj expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients AT chenw expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients AT yuand expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients AT wangw expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients AT chenx expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients AT liuh expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients AT suh expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients AT zhuj expressionandroleofdickkopf1dkk1intumorsfromthecellstothepatients |