Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications
Diabetes mellitus (DM) is a metabolic disease, now prevalent worldwide, which is characterized by a relative or absolute lack of insulin secretion leading to chronically increased blood glucose levels. Diabetic patients are often accompanied by multiple macrovascular complications, such as coronary...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.646233/full |
| _version_ | 1818898680093081600 |
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| author | Jiachao Xiong Hao Hu Rong Guo Hui Wang Hua Jiang |
| author_facet | Jiachao Xiong Hao Hu Rong Guo Hui Wang Hua Jiang |
| author_sort | Jiachao Xiong |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a metabolic disease, now prevalent worldwide, which is characterized by a relative or absolute lack of insulin secretion leading to chronically increased blood glucose levels. Diabetic patients are often accompanied by multiple macrovascular complications, such as coronary heart disease, hypertension, macrovascular arteriosclerosis, and microvascular complications. Microvascular complications include diabetic kidney injury, diabetic encephalopathy, and diabetic foot, which reduce the quality of life and survival status of patients. Mesenchymal stem cell exosomes (MSC-Exos) possess repair functions similar to MSCs, low immunogenicity, and ease of storage and transport. MSC-Exos have been proven to possess excellent repair effects in repairing various organ damages. This study reviews the application of MSC-Exos in the treatment of DM and its common complications. MSC-Exos may be used as an effective treatment for DM and its complications. |
| first_indexed | 2024-12-19T19:35:55Z |
| format | Article |
| id | doaj.art-e64084a6af794c06a4ed8fb78227e44f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-19T19:35:55Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e64084a6af794c06a4ed8fb78227e44f2022-12-21T20:08:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-04-011210.3389/fendo.2021.646233646233Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes ComplicationsJiachao XiongHao HuRong GuoHui WangHua JiangDiabetes mellitus (DM) is a metabolic disease, now prevalent worldwide, which is characterized by a relative or absolute lack of insulin secretion leading to chronically increased blood glucose levels. Diabetic patients are often accompanied by multiple macrovascular complications, such as coronary heart disease, hypertension, macrovascular arteriosclerosis, and microvascular complications. Microvascular complications include diabetic kidney injury, diabetic encephalopathy, and diabetic foot, which reduce the quality of life and survival status of patients. Mesenchymal stem cell exosomes (MSC-Exos) possess repair functions similar to MSCs, low immunogenicity, and ease of storage and transport. MSC-Exos have been proven to possess excellent repair effects in repairing various organ damages. This study reviews the application of MSC-Exos in the treatment of DM and its common complications. MSC-Exos may be used as an effective treatment for DM and its complications.https://www.frontiersin.org/articles/10.3389/fendo.2021.646233/fulldiabetes mellituscomplicationmicrovascular damagemesenchymal stem cellsexosomes |
| spellingShingle | Jiachao Xiong Hao Hu Rong Guo Hui Wang Hua Jiang Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications Frontiers in Endocrinology diabetes mellitus complication microvascular damage mesenchymal stem cells exosomes |
| title | Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications |
| title_full | Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications |
| title_fullStr | Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications |
| title_full_unstemmed | Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications |
| title_short | Mesenchymal Stem Cell Exosomes as a New Strategy for the Treatment of Diabetes Complications |
| title_sort | mesenchymal stem cell exosomes as a new strategy for the treatment of diabetes complications |
| topic | diabetes mellitus complication microvascular damage mesenchymal stem cells exosomes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.646233/full |
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