Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019
ABSTRACT: Background: Nasopharyngeal (NP) colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) is common in children, and may evolve as the source of invasive infections. In Korea, the pneumococcal conjugate vaccines (PCVs) were introduced >10 years ago, enab...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221006986 |
| _version_ | 1818930497325105152 |
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| author | Young June Choe Mi Seon Han Youn Young Choi Young Joo Sohn Ye Kyung Kim Kyung Min Kim Ji Young Park Hyun Mi Kang In Ae Yoon Jae Hong Choi Chi Eun Oh Eun Young Cho Hyunju Lee Eun Hwa Choi |
| author_facet | Young June Choe Mi Seon Han Youn Young Choi Young Joo Sohn Ye Kyung Kim Kyung Min Kim Ji Young Park Hyun Mi Kang In Ae Yoon Jae Hong Choi Chi Eun Oh Eun Young Cho Hyunju Lee Eun Hwa Choi |
| author_sort | Young June Choe |
| collection | DOAJ |
| description | ABSTRACT: Background: Nasopharyngeal (NP) colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) is common in children, and may evolve as the source of invasive infections. In Korea, the pneumococcal conjugate vaccines (PCVs) were introduced >10 years ago, enabling the authors to study the effect of the vaccine in preventing carriage. Methods: NP swabs were taken and a household survey was conducted at daycare centres located in different regions of Korea in 2014 and 2019. Pneumococcal serotypes were identified using the Quellung method and sequencing. NTHi were identified based on pilA and bexA genes. Results: In total, 1460 NP swabs were obtained with pneumococcal carriage rates of 36.4–42.1% and NTHi carriage rates of 36.5–26.7%. Among children carrying pneumococci, a significant increase was seen in serotype 23A between 2014 and 2019 (from 12.6% to 22.0%; P=0.005). Children who had received PCV were at lower risk of vaccine-type carriage (2.9% vs 0.8%; P=0.005). Conclusions: Between 2014 and 2019, the proportion of children carrying serotype 23A increased significantly, while the carriage rate of NTHi decreased. Continuous surveillance is needed to assess the long-term effects of the PCVs on carriage dynamics of pneumococcus and NTHi. |
| first_indexed | 2024-12-20T04:01:38Z |
| format | Article |
| id | doaj.art-e640b9fefcc04e5c9e8149bf79e1f3e4 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-20T04:01:38Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-e640b9fefcc04e5c9e8149bf79e1f3e42022-12-21T19:54:09ZengElsevierInternational Journal of Infectious Diseases1201-97122021-10-01111328332Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019Young June Choe0Mi Seon Han1Youn Young Choi2Young Joo Sohn3Ye Kyung Kim4Kyung Min Kim5Ji Young Park6Hyun Mi Kang7In Ae Yoon8Jae Hong Choi9Chi Eun Oh10Eun Young Cho11Hyunju Lee12Eun Hwa Choi13Department of Paediatrics, Korea University Anam Hospital, Seoul, KoreaDepartment of Paediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Centre, Seoul, KoreaDepartment of Paediatrics, National Medical Centre, Seoul, KoreaDepartment of Paediatrics, Seoul National University Hospital, Seoul, Seoul, KoreaDepartment of Paediatrics, Seoul National University Hospital, Seoul, Seoul, KoreaDepartment of Paediatrics, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Paediatrics, Chung-Ang University Hospital, Seoul, KoreaDepartment of Paediatrics, Seoul St. Mary's Hospital, Seoul, KoreaDepartment of Paediatrics, Seongnam Citizen Medical Centre, Seongnam, KoreaDepartment of Paediatrics, Jeju National University Hospital, Jeju, KoreaDepartment of Paediatrics, Kosin University College of Medicine, Busan, KoreaDepartment of Paediatrics, Chungnam National University College of Medicine, Daejeon, KoreaDepartment of Paediatrics, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Paediatrics, Seoul National University Hospital, Seoul, Seoul, Korea; Corresponding author. Address: Seoul National University College of Medicine; 101 Daehak-ro, Jongno-gu, Seoul 110-769, Korea. Tel.: +82 2 2072 3624; fax: +82 2 766 7283.ABSTRACT: Background: Nasopharyngeal (NP) colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) is common in children, and may evolve as the source of invasive infections. In Korea, the pneumococcal conjugate vaccines (PCVs) were introduced >10 years ago, enabling the authors to study the effect of the vaccine in preventing carriage. Methods: NP swabs were taken and a household survey was conducted at daycare centres located in different regions of Korea in 2014 and 2019. Pneumococcal serotypes were identified using the Quellung method and sequencing. NTHi were identified based on pilA and bexA genes. Results: In total, 1460 NP swabs were obtained with pneumococcal carriage rates of 36.4–42.1% and NTHi carriage rates of 36.5–26.7%. Among children carrying pneumococci, a significant increase was seen in serotype 23A between 2014 and 2019 (from 12.6% to 22.0%; P=0.005). Children who had received PCV were at lower risk of vaccine-type carriage (2.9% vs 0.8%; P=0.005). Conclusions: Between 2014 and 2019, the proportion of children carrying serotype 23A increased significantly, while the carriage rate of NTHi decreased. Continuous surveillance is needed to assess the long-term effects of the PCVs on carriage dynamics of pneumococcus and NTHi.http://www.sciencedirect.com/science/article/pii/S1201971221006986Streptococcus pneumoniaePneumococcusHaemophilus influenzaeNTHiCarriageChildren |
| spellingShingle | Young June Choe Mi Seon Han Youn Young Choi Young Joo Sohn Ye Kyung Kim Kyung Min Kim Ji Young Park Hyun Mi Kang In Ae Yoon Jae Hong Choi Chi Eun Oh Eun Young Cho Hyunju Lee Eun Hwa Choi Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019 International Journal of Infectious Diseases Streptococcus pneumoniae Pneumococcus Haemophilus influenzae NTHi Carriage Children |
| title | Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019 |
| title_full | Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019 |
| title_fullStr | Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019 |
| title_full_unstemmed | Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019 |
| title_short | Trend change of nasopharyngeal colonization with Streptococcus pneumoniae and non-typeable Haemophilus influenzae in children attending daycare centres: nationwide population-based study, South Korea 2014 and 2019 |
| title_sort | trend change of nasopharyngeal colonization with streptococcus pneumoniae and non typeable haemophilus influenzae in children attending daycare centres nationwide population based study south korea 2014 and 2019 |
| topic | Streptococcus pneumoniae Pneumococcus Haemophilus influenzae NTHi Carriage Children |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221006986 |
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