Comparison of Therapeutic Effects of Linagliptin and Metformin in Patients with Type 2 Diabetes: A systematic Review and Meta-Analysis
Background & objectives: Type 2 diabetes mellitus (DM) is a metabolic disorder that is common throughout the world. Meta-analysis is a statistical technique in which the results of two or more independent studies, with similar objectives, are mathematically combined in order to improve the relia...
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| Format: | Article |
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Ardabil University of Medical Sciences
2018-04-01
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| Series: | Journal of Ardabil University of Medical Sciences |
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| Online Access: | http://jarums.arums.ac.ir/browse.php?a_code=A-10-607-100&slc_lang=en&sid=1 |
| _version_ | 1819061665051705344 |
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| author | Hamidreza Dehghan Masoud Mirzaei Ebrahim Mirzaei Eslam Moradei Asl Amin Ataiy Mahbobeh Mirzaei |
| author_facet | Hamidreza Dehghan Masoud Mirzaei Ebrahim Mirzaei Eslam Moradei Asl Amin Ataiy Mahbobeh Mirzaei |
| author_sort | Hamidreza Dehghan |
| collection | DOAJ |
| description | Background & objectives: Type 2 diabetes mellitus (DM) is a metabolic disorder that is common throughout the world. Meta-analysis is a statistical technique in which the results of two or more independent studies, with similar objectives, are mathematically combined in order to improve the reliability of the results. The aim of this study was to compare the efficacy of metformin and linagliptin in patients with type 2 diabetes.
Methods: To identify relevant studies, PubMed, ISI Web of Science, Embase, Cochran library, Scopus and Ovid databases were searched from January 2000 to August 2016. Mean difference (MD) with 95% confidence interval (CI) for efficacy were calculated and pooled analysis was performed using Stata V.12 and RevMan V.5.3 software.
Results: Four studies recruiting1260 patients with DM (682 patients in group linagliptin and 578 patients in metformin group) were included in this study. The MD of HbA1C outcome of 0.5 mg linagliptin was effective (0. 7295, % CI = 0. 69 - 0. 75). The MD of fasting blood sugar (FBS) test revealed that linagliptin was effective at 0.5mg (MD = 36.79, 95% CI = 35.20 - 38.38) and 5 mg (MD = 12.65, 95% CI = 2.68 to 22.63) doses.
Conclusion: Our results suggest that some doses of linagliptin versus metformin may be an effective treatment for DM2. However, the number of studies was limited, and further research is needed.
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| first_indexed | 2024-12-21T14:46:29Z |
| format | Article |
| id | doaj.art-e64298bebd244d72982385153d30415b |
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| issn | 2228-7280 2228-7299 |
| language | fas |
| last_indexed | 2024-12-21T14:46:29Z |
| publishDate | 2018-04-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj.art-e64298bebd244d72982385153d30415b2022-12-21T19:00:01ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992018-04-011812133Comparison of Therapeutic Effects of Linagliptin and Metformin in Patients with Type 2 Diabetes: A systematic Review and Meta-AnalysisHamidreza Dehghan0Masoud Mirzaei1Ebrahim Mirzaei2Eslam Moradei Asl3Amin Ataiy4Mahbobeh Mirzaei5 Department of Health Technology Assessment, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Health Technology Assessment, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Health Technology Assessment, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Public Health, School of Public Health, Ardabil University of Medical Sciences, Ardabil, Iran Meshkin shahr of Health Center, Ardabil University of medical sciences, Ardabil, Iran Department of Physical Education & Sport Sciences, Kharazmi University, Tehran, Iran Background & objectives: Type 2 diabetes mellitus (DM) is a metabolic disorder that is common throughout the world. Meta-analysis is a statistical technique in which the results of two or more independent studies, with similar objectives, are mathematically combined in order to improve the reliability of the results. The aim of this study was to compare the efficacy of metformin and linagliptin in patients with type 2 diabetes. Methods: To identify relevant studies, PubMed, ISI Web of Science, Embase, Cochran library, Scopus and Ovid databases were searched from January 2000 to August 2016. Mean difference (MD) with 95% confidence interval (CI) for efficacy were calculated and pooled analysis was performed using Stata V.12 and RevMan V.5.3 software. Results: Four studies recruiting1260 patients with DM (682 patients in group linagliptin and 578 patients in metformin group) were included in this study. The MD of HbA1C outcome of 0.5 mg linagliptin was effective (0. 7295, % CI = 0. 69 - 0. 75). The MD of fasting blood sugar (FBS) test revealed that linagliptin was effective at 0.5mg (MD = 36.79, 95% CI = 35.20 - 38.38) and 5 mg (MD = 12.65, 95% CI = 2.68 to 22.63) doses. Conclusion: Our results suggest that some doses of linagliptin versus metformin may be an effective treatment for DM2. However, the number of studies was limited, and further research is needed. http://jarums.arums.ac.ir/browse.php?a_code=A-10-607-100&slc_lang=en&sid=1Linagliptin Metformin Type 2 Diabetes Safety Treatment |
| spellingShingle | Hamidreza Dehghan Masoud Mirzaei Ebrahim Mirzaei Eslam Moradei Asl Amin Ataiy Mahbobeh Mirzaei Comparison of Therapeutic Effects of Linagliptin and Metformin in Patients with Type 2 Diabetes: A systematic Review and Meta-Analysis Journal of Ardabil University of Medical Sciences Linagliptin Metformin Type 2 Diabetes Safety Treatment |
| title | Comparison of Therapeutic Effects of Linagliptin and Metformin in Patients with Type 2 Diabetes: A systematic Review and
Meta-Analysis |
| title_full | Comparison of Therapeutic Effects of Linagliptin and Metformin in Patients with Type 2 Diabetes: A systematic Review and
Meta-Analysis |
| title_fullStr | Comparison of Therapeutic Effects of Linagliptin and Metformin in Patients with Type 2 Diabetes: A systematic Review and
Meta-Analysis |
| title_full_unstemmed | Comparison of Therapeutic Effects of Linagliptin and Metformin in Patients with Type 2 Diabetes: A systematic Review and
Meta-Analysis |
| title_short | Comparison of Therapeutic Effects of Linagliptin and Metformin in Patients with Type 2 Diabetes: A systematic Review and
Meta-Analysis |
| title_sort | comparison of therapeutic effects of linagliptin and metformin in patients with type 2 diabetes a systematic review and meta analysis |
| topic | Linagliptin Metformin Type 2 Diabetes Safety Treatment |
| url | http://jarums.arums.ac.ir/browse.php?a_code=A-10-607-100&slc_lang=en&sid=1 |
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