The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis
Introduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) of angiotensin-converting enzyme ( ACE ) polymorphism confers susceptibility to psoriasis, vitiligo and rheumatoid arthritis (RA). Materials and methods: A meta-analysis was conducted on the association...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2015-03-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320313478285 |
| _version_ | 1797289004923617280 |
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| author | Gwan Gyu Song Sang-Cheol Bae Jae-Hoon Kim Young Ho Lee |
| author_facet | Gwan Gyu Song Sang-Cheol Bae Jae-Hoon Kim Young Ho Lee |
| author_sort | Gwan Gyu Song |
| collection | DOAJ |
| description | Introduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) of angiotensin-converting enzyme ( ACE ) polymorphism confers susceptibility to psoriasis, vitiligo and rheumatoid arthritis (RA). Materials and methods: A meta-analysis was conducted on the association between the ACE I/D polymorphisms and psoriasis, vitiligo and RA. Results: Fifteen studies comprising five on psoriasis, five on vitiligo and five on RA were available for the meta-analysis consisting of 2094 cases and 2871 controls. Meta-analysis of the DD+ID genotype showed significant associations with psoriasis (odds ratio (OR) 0.753, 95% confidence interval (CI) 0.601–0.921, p = 0.006). Meta-analysis showed no association between vitiligo and the ACE I/D polymorphism. Meta-analysis of the DD+ID genotype showed an association with RA (OR 2.199, 95% CI 1.379–3.506, p = 0.001). Ethnicity-specific meta-analysis of the D allele showed no association with psoriasis in Europeans, and vitiligo in South Asians. However, subgroup analysis by ethnicity revealed a significant association between the D allele and RA in Arab populations (OR 2.697, 95% CI 1.803–4.034, p = 1.3 × 10 −5 ). Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to RA, especially in Arab populations. |
| first_indexed | 2024-03-07T18:57:50Z |
| format | Article |
| id | doaj.art-e6432f1a02b249eda99ebc56e36f3c92 |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:57:50Z |
| publishDate | 2015-03-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-e6432f1a02b249eda99ebc56e36f3c922024-03-02T00:08:16ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-03-011610.1177/1470320313478285The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysisGwan Gyu Song0Sang-Cheol Bae1Jae-Hoon Kim2Young Ho Lee3 Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, KoreaIntroduction: The purpose of this study was to examine whether the insertion (I) and deletion (D) of angiotensin-converting enzyme ( ACE ) polymorphism confers susceptibility to psoriasis, vitiligo and rheumatoid arthritis (RA). Materials and methods: A meta-analysis was conducted on the association between the ACE I/D polymorphisms and psoriasis, vitiligo and RA. Results: Fifteen studies comprising five on psoriasis, five on vitiligo and five on RA were available for the meta-analysis consisting of 2094 cases and 2871 controls. Meta-analysis of the DD+ID genotype showed significant associations with psoriasis (odds ratio (OR) 0.753, 95% confidence interval (CI) 0.601–0.921, p = 0.006). Meta-analysis showed no association between vitiligo and the ACE I/D polymorphism. Meta-analysis of the DD+ID genotype showed an association with RA (OR 2.199, 95% CI 1.379–3.506, p = 0.001). Ethnicity-specific meta-analysis of the D allele showed no association with psoriasis in Europeans, and vitiligo in South Asians. However, subgroup analysis by ethnicity revealed a significant association between the D allele and RA in Arab populations (OR 2.697, 95% CI 1.803–4.034, p = 1.3 × 10 −5 ). Conclusions: Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to RA, especially in Arab populations.https://doi.org/10.1177/1470320313478285 |
| spellingShingle | Gwan Gyu Song Sang-Cheol Bae Jae-Hoon Kim Young Ho Lee The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis Journal of the Renin-Angiotensin-Aldosterone System |
| title | The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis |
| title_full | The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis |
| title_fullStr | The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis |
| title_full_unstemmed | The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis |
| title_short | The angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to rheumatoid arthritis, vitiligo and psoriasis: A meta-analysis |
| title_sort | angiotensin converting enzyme insertion deletion polymorphism and susceptibility to rheumatoid arthritis vitiligo and psoriasis a meta analysis |
| url | https://doi.org/10.1177/1470320313478285 |
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