Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies
Systemic Sclerosis (SSc) is an autoimmune disease marked by dysregulation of the immune system, tissue fibrosis and dysfunction of the vasculature. Vascular damage, remodeling and inadequate endothelial repair are hallmarks of the disease. Since early stages of SSc, damage and apoptosis of endotheli...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.788250/full |
| _version_ | 1828138651241938944 |
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| author | Djúlio César Zanin-Silva Djúlio César Zanin-Silva Maynara Santana-Gonçalves Maynara Santana-Gonçalves Marianna Yumi Kawashima-Vasconcelos Marianna Yumi Kawashima-Vasconcelos Maria Carolina Oliveira Maria Carolina Oliveira |
| author_facet | Djúlio César Zanin-Silva Djúlio César Zanin-Silva Maynara Santana-Gonçalves Maynara Santana-Gonçalves Marianna Yumi Kawashima-Vasconcelos Marianna Yumi Kawashima-Vasconcelos Maria Carolina Oliveira Maria Carolina Oliveira |
| author_sort | Djúlio César Zanin-Silva |
| collection | DOAJ |
| description | Systemic Sclerosis (SSc) is an autoimmune disease marked by dysregulation of the immune system, tissue fibrosis and dysfunction of the vasculature. Vascular damage, remodeling and inadequate endothelial repair are hallmarks of the disease. Since early stages of SSc, damage and apoptosis of endothelial cells (ECs) can lead to perivascular inflammation, oxidative stress and tissue hypoxia, resulting in multiple clinical manifestations. Raynaud's phenomenon, edematous puffy hands, digital ulcers, pulmonary artery hypertension, erectile dysfunction, scleroderma renal crisis and heart involvement severely affect quality of life and survival. Understanding pathogenic aspects and biomarkers that reflect endothelial damage in SSc is essential to guide therapeutic interventions. Treatment approaches described for SSc-associated vasculopathy include pharmacological options to improve blood flow and tissue perfusion and, more recently, cellular therapy to enhance endothelial repair, promote angiogenesis and heal injuries. This mini-review examines the current knowledge on cellular and molecular aspects of SSc vasculopathy, as well as established and developing therapeutic approaches for improving the vascular compartment. |
| first_indexed | 2024-04-11T18:39:06Z |
| format | Article |
| id | doaj.art-e644508ce0784d5192c569b916bd92de |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T18:39:06Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e644508ce0784d5192c569b916bd92de2022-12-22T04:09:04ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-12-01810.3389/fmed.2021.788250788250Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing StrategiesDjúlio César Zanin-Silva0Djúlio César Zanin-Silva1Maynara Santana-Gonçalves2Maynara Santana-Gonçalves3Marianna Yumi Kawashima-Vasconcelos4Marianna Yumi Kawashima-Vasconcelos5Maria Carolina Oliveira6Maria Carolina Oliveira7Center for Cell-Based Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilBasic and Applied Immunology Graduate Program, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilCenter for Cell-Based Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilOncology, Stem Cell and Cell-Therapy Graduate Program, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilCenter for Cell-Based Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilInternal Medicine Graduate Program, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilCenter for Cell-Based Therapy, Regional Hemotherapy Center of the Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilSystemic Sclerosis (SSc) is an autoimmune disease marked by dysregulation of the immune system, tissue fibrosis and dysfunction of the vasculature. Vascular damage, remodeling and inadequate endothelial repair are hallmarks of the disease. Since early stages of SSc, damage and apoptosis of endothelial cells (ECs) can lead to perivascular inflammation, oxidative stress and tissue hypoxia, resulting in multiple clinical manifestations. Raynaud's phenomenon, edematous puffy hands, digital ulcers, pulmonary artery hypertension, erectile dysfunction, scleroderma renal crisis and heart involvement severely affect quality of life and survival. Understanding pathogenic aspects and biomarkers that reflect endothelial damage in SSc is essential to guide therapeutic interventions. Treatment approaches described for SSc-associated vasculopathy include pharmacological options to improve blood flow and tissue perfusion and, more recently, cellular therapy to enhance endothelial repair, promote angiogenesis and heal injuries. This mini-review examines the current knowledge on cellular and molecular aspects of SSc vasculopathy, as well as established and developing therapeutic approaches for improving the vascular compartment.https://www.frontiersin.org/articles/10.3389/fmed.2021.788250/fullsystemic sclerosisvasculopathycellular therapyendothelial cellsvasodilator agent |
| spellingShingle | Djúlio César Zanin-Silva Djúlio César Zanin-Silva Maynara Santana-Gonçalves Maynara Santana-Gonçalves Marianna Yumi Kawashima-Vasconcelos Marianna Yumi Kawashima-Vasconcelos Maria Carolina Oliveira Maria Carolina Oliveira Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies Frontiers in Medicine systemic sclerosis vasculopathy cellular therapy endothelial cells vasodilator agent |
| title | Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies |
| title_full | Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies |
| title_fullStr | Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies |
| title_full_unstemmed | Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies |
| title_short | Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies |
| title_sort | management of endothelial dysfunction in systemic sclerosis current and developing strategies |
| topic | systemic sclerosis vasculopathy cellular therapy endothelial cells vasodilator agent |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.788250/full |
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