Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies

Unequal Behaviour between Hydrolysable Functions of Nirmatrelvir under Stress Conditions: Structural and Theoretical Approaches in Support of Preformulation Studies

Nirmatrelvir is an antiviral drug approved for the treatment of COVID-19. The available dosage form consists of tablets marketed under the brand name PAXLOVID<sup>®</sup>. Although knowledge of nirmatrelvir’s intrinsic stability may be useful for any potential development of other pharma...

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Bibliographic Details
Main Authors: Philippe-Henri Secretan, Maxime Annereau, Willy Kini-Matondo, Bastien Prost, Jade Prudhomme, Lina Bournane, Muriel Paul, Najet Yagoubi, Hassane Sadou-Yayé, Bernard Do
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
selective hydrolysis
ab initio calculations
DFT
mass spectrometry
degradation products
preformulation studies
Online Access:https://www.mdpi.com/1999-4923/14/8/1720

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