Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients

Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients

Fetal hemoglobin (HbF), encoded by the HBG2 and HBG1 genes, is the best-known genetic modulator of sickle cell anemia, varying dramatically in concentration in the blood of these patients. This variation is partially associated with polymorphisms located in the promoter region of the HBG2 and HBG1 g...

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Bibliographic Details
Main Authors:	C.G. Barbosa, N.J. Goncalves-Santos, S.B. Souza-Ribeiro, J.P. Moura-Neto, D. Takahashi, D.O. Silva, A.F. Hurtado-Guerrero, M.G. Reis, M.S. Goncalves
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2010-08-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Fetal hemoglobin Sickle cell anemia HBG1 gene HBG2 gene
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000800002

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