Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy
Combination therapy which enhances efficacy and reduces toxicity, has been increasingly applied as a promising strategy for cancer therapy. Here, a reactive oxygen species (ROS) that enhanced combination chemotherapy nanodevices was fabricated based on the Fe-chelated polydopamine (PDA) nanoparticle...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2019.00075/full |
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| author | Xu-Jing Li Wen-Tong Li Wen-Tong Li Zi-Hao-Ran Li Li-Ping Zhang Cheng-Cheng Gai Wei-Fen Zhang Wei-Fen Zhang De-Jun Ding De-Jun Ding |
| author_facet | Xu-Jing Li Wen-Tong Li Wen-Tong Li Zi-Hao-Ran Li Li-Ping Zhang Cheng-Cheng Gai Wei-Fen Zhang Wei-Fen Zhang De-Jun Ding De-Jun Ding |
| author_sort | Xu-Jing Li |
| collection | DOAJ |
| description | Combination therapy which enhances efficacy and reduces toxicity, has been increasingly applied as a promising strategy for cancer therapy. Here, a reactive oxygen species (ROS) that enhanced combination chemotherapy nanodevices was fabricated based on the Fe-chelated polydopamine (PDA) nanoparticles (NPs). The structure was characterized by dynamic light scattering-autosizer, transmission electron microscopy, energy dispersive spectroscopy, and Fourier-transform infrared (FT-IR) spectrophotometer. The in vitro drug release profile triggered by low intracellular pH indicated that the system demonstrated controlled therapeutic activity. In vitro cell uptake studies showed that doxorubicin (DOX)-loaded Fe-PDA/ folic acid (FA)- polyethylene glycol (DOX@Fe-PDA/FA-PEG) had a strong uptake capacity and can be rapidly internalized by MCF-7 cells. The in vitro experiments demonstrated that DOX@Fe-PDA/FA-PEG triggered the intracellular ROS overproduction, thereby enhancing its therapeutic effect on breast cancer. In summary, this experiment demonstrated the novel DOX-loaded composite NPs used as a potential targeted nanocarrier for breast cancer treatment, which could be a promising therapeutic strategy against breast cancer. |
| first_indexed | 2024-12-11T16:37:21Z |
| format | Article |
| id | doaj.art-e647151eb62241c08d80625dbd609fe2 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T16:37:21Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-e647151eb62241c08d80625dbd609fe22022-12-22T00:58:25ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-02-011010.3389/fphar.2019.00075442167Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination TherapyXu-Jing Li0Wen-Tong Li1Wen-Tong Li2Zi-Hao-Ran Li3Li-Ping Zhang4Cheng-Cheng Gai5Wei-Fen Zhang6Wei-Fen Zhang7De-Jun Ding8De-Jun Ding9Department of Pathology, Weifang Medical University, Weifang, ChinaDepartment of Pathology, Weifang Medical University, Weifang, ChinaCollaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang, ChinaDepartment of Pathology, Weifang Medical University, Weifang, ChinaCollege of Pharmacy, Weifang Medical University, Weifang, ChinaDepartment of Pathology, Weifang Medical University, Weifang, ChinaCollaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang, ChinaCollege of Pharmacy, Weifang Medical University, Weifang, ChinaCollaborative Innovation Center for Target Drug Delivery System, Weifang Medical University, Weifang, ChinaCollege of Pharmacy, Weifang Medical University, Weifang, ChinaCombination therapy which enhances efficacy and reduces toxicity, has been increasingly applied as a promising strategy for cancer therapy. Here, a reactive oxygen species (ROS) that enhanced combination chemotherapy nanodevices was fabricated based on the Fe-chelated polydopamine (PDA) nanoparticles (NPs). The structure was characterized by dynamic light scattering-autosizer, transmission electron microscopy, energy dispersive spectroscopy, and Fourier-transform infrared (FT-IR) spectrophotometer. The in vitro drug release profile triggered by low intracellular pH indicated that the system demonstrated controlled therapeutic activity. In vitro cell uptake studies showed that doxorubicin (DOX)-loaded Fe-PDA/ folic acid (FA)- polyethylene glycol (DOX@Fe-PDA/FA-PEG) had a strong uptake capacity and can be rapidly internalized by MCF-7 cells. The in vitro experiments demonstrated that DOX@Fe-PDA/FA-PEG triggered the intracellular ROS overproduction, thereby enhancing its therapeutic effect on breast cancer. In summary, this experiment demonstrated the novel DOX-loaded composite NPs used as a potential targeted nanocarrier for breast cancer treatment, which could be a promising therapeutic strategy against breast cancer.https://www.frontiersin.org/article/10.3389/fphar.2019.00075/fullpolydopaminecombination therapyreactive oxygen speciesdoxorubicinbreast cancer |
| spellingShingle | Xu-Jing Li Wen-Tong Li Wen-Tong Li Zi-Hao-Ran Li Li-Ping Zhang Cheng-Cheng Gai Wei-Fen Zhang Wei-Fen Zhang De-Jun Ding De-Jun Ding Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy Frontiers in Pharmacology polydopamine combination therapy reactive oxygen species doxorubicin breast cancer |
| title | Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy |
| title_full | Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy |
| title_fullStr | Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy |
| title_full_unstemmed | Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy |
| title_short | Iron-Chelated Polydopamine Decorated Doxorubicin-Loaded Nanodevices for Reactive Oxygen Species Enhanced Cancer Combination Therapy |
| title_sort | iron chelated polydopamine decorated doxorubicin loaded nanodevices for reactive oxygen species enhanced cancer combination therapy |
| topic | polydopamine combination therapy reactive oxygen species doxorubicin breast cancer |
| url | https://www.frontiersin.org/article/10.3389/fphar.2019.00075/full |
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