Cerebellar development after preterm birth
Preterm birth and its complications and the associated adverse factors, including brain hemorrhage, inflammation, and the side effects of medical treatments, are the leading causes of neurodevelopmental disability. Growing evidence suggests that preterm birth affects the cerebellum, which is the bra...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1068288/full |
| _version_ | 1828097215719014400 |
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| author | Igor Y. Iskusnykh Victor V. Chizhikov |
| author_facet | Igor Y. Iskusnykh Victor V. Chizhikov |
| author_sort | Igor Y. Iskusnykh |
| collection | DOAJ |
| description | Preterm birth and its complications and the associated adverse factors, including brain hemorrhage, inflammation, and the side effects of medical treatments, are the leading causes of neurodevelopmental disability. Growing evidence suggests that preterm birth affects the cerebellum, which is the brain region involved in motor coordination, cognition, learning, memory, and social communication. The cerebellum is particularly vulnerable to the adverse effects of preterm birth because key cerebellar developmental processes, including the proliferation of neural progenitors, and differentiation and migration of neurons, occur in the third trimester of a human pregnancy. This review discusses the negative impacts of preterm birth and its associated factors on cerebellar development, focusing on the cellular and molecular mechanisms that mediate cerebellar pathology. A better understanding of the cerebellar developmental mechanisms affected by preterm birth is necessary for developing novel treatment and neuroprotective strategies to ameliorate the cognitive, behavioral, and motor deficits experienced by preterm subjects. |
| first_indexed | 2024-04-11T07:43:27Z |
| format | Article |
| id | doaj.art-e6477c4d90de425a8fa887377dcfbbd8 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T07:43:27Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e6477c4d90de425a8fa887377dcfbbd82022-12-22T04:36:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-11-011010.3389/fcell.2022.10682881068288Cerebellar development after preterm birthIgor Y. IskusnykhVictor V. ChizhikovPreterm birth and its complications and the associated adverse factors, including brain hemorrhage, inflammation, and the side effects of medical treatments, are the leading causes of neurodevelopmental disability. Growing evidence suggests that preterm birth affects the cerebellum, which is the brain region involved in motor coordination, cognition, learning, memory, and social communication. The cerebellum is particularly vulnerable to the adverse effects of preterm birth because key cerebellar developmental processes, including the proliferation of neural progenitors, and differentiation and migration of neurons, occur in the third trimester of a human pregnancy. This review discusses the negative impacts of preterm birth and its associated factors on cerebellar development, focusing on the cellular and molecular mechanisms that mediate cerebellar pathology. A better understanding of the cerebellar developmental mechanisms affected by preterm birth is necessary for developing novel treatment and neuroprotective strategies to ameliorate the cognitive, behavioral, and motor deficits experienced by preterm subjects.https://www.frontiersin.org/articles/10.3389/fcell.2022.1068288/fullpreterm birthcerebellumneurogenesisgranule cellsPurkinje cellsglia |
| spellingShingle | Igor Y. Iskusnykh Victor V. Chizhikov Cerebellar development after preterm birth Frontiers in Cell and Developmental Biology preterm birth cerebellum neurogenesis granule cells Purkinje cells glia |
| title | Cerebellar development after preterm birth |
| title_full | Cerebellar development after preterm birth |
| title_fullStr | Cerebellar development after preterm birth |
| title_full_unstemmed | Cerebellar development after preterm birth |
| title_short | Cerebellar development after preterm birth |
| title_sort | cerebellar development after preterm birth |
| topic | preterm birth cerebellum neurogenesis granule cells Purkinje cells glia |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1068288/full |
| work_keys_str_mv | AT igoryiskusnykh cerebellardevelopmentafterpretermbirth AT victorvchizhikov cerebellardevelopmentafterpretermbirth |