Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo.

Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo.

The α-defensins, human neutrophil peptides (HNPs) are the predominant antimicrobial peptides of neutrophil granules. They are synthesized in promyelocytes and myelocytes as proHNPs, but only processed in promyelocytes and stored as mature HNPs in azurophil granules. Despite decades of search, the me...

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Bibliographic Details
Main Authors: Andreas Glenthøj, Katrin Nickles, Jack Cowland, Niels Borregaard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4422583?pdf=render

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