Insights into Aptamer–Drug Delivery Systems against Prostate Cancer
Prostate cancer is a common cancer in elderly males. Significant progress has been made in the drug therapies for prostate cancer in recent years. However, side effects are still problems that have not been overcome by the currently used anti-prostate cancer drugs. Novel technologies can be applied...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/11/3446 |
| _version_ | 1797492526523875328 |
|---|---|
| author | Xueni Wang Qian Zhou Xiaoning Li Xia Gan Peng Liu Xiaotao Feng Gang Fang Yonghong Liu |
| author_facet | Xueni Wang Qian Zhou Xiaoning Li Xia Gan Peng Liu Xiaotao Feng Gang Fang Yonghong Liu |
| author_sort | Xueni Wang |
| collection | DOAJ |
| description | Prostate cancer is a common cancer in elderly males. Significant progress has been made in the drug therapies for prostate cancer in recent years. However, side effects are still problems that have not been overcome by the currently used anti-prostate cancer drugs. Novel technologies can be applied to reduce or even eliminate the side effects of drugs. An aptamer may be a sequence of nucleic acids or peptides that can specifically recognize proteins or cells. Taking advantage of this feature, scientists have designed aptamer–drug delivery systems for the development of anti-prostate cancer agents. Theoretically, these aptamer–drug delivery systems can specifically recognize prostate cancer cells and then induce cell death without attacking normal cells. We collected the relevant literature in this field and found that at least nine compounds have been prepared as aptamer–drug delivery systems to evaluate their precise anti-prostate cancer effects. However, the currently studied aptamer–drug delivery systems have not yet entered the market due to defects. Here, we analyze the published data, summarize the characteristics of these delivery systems, and propose ways to promote their application, thus promoting the development of the aptamer–drug delivery systems against prostate cancer. |
| first_indexed | 2024-03-10T01:04:57Z |
| format | Article |
| id | doaj.art-e64c5f73605f4f5ead863ee0a382a43e |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T01:04:57Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e64c5f73605f4f5ead863ee0a382a43e2023-11-23T14:28:52ZengMDPI AGMolecules1420-30492022-05-012711344610.3390/molecules27113446Insights into Aptamer–Drug Delivery Systems against Prostate CancerXueni Wang0Qian Zhou1Xiaoning Li2Xia Gan3Peng Liu4Xiaotao Feng5Gang Fang6Yonghong Liu7Guangxi Zhuang Yao Medicine Center of Engineering and Technology, Guangxi University of Chinese Medicine, 13 Wuhe Road, Qingxiu District, Nanning 530200, ChinaGuangxi Zhuang Yao Medicine Center of Engineering and Technology, Guangxi University of Chinese Medicine, 13 Wuhe Road, Qingxiu District, Nanning 530200, ChinaSchool of Foreign Languages, Nanning Normal University, 3 Hexing Road, Qingxiu District, Nanning 530299, ChinaGuangxi Zhuang Yao Medicine Center of Engineering and Technology, Guangxi University of Chinese Medicine, 13 Wuhe Road, Qingxiu District, Nanning 530200, ChinaCenter for Medical Innovation, School of Basic Medical Science, Guangxi University of Chinese Medicine, 13 Wuhe Road, Qingxiu District, Nanning 530200, ChinaGuangxi Key Laboratory of Chinese Medicine Foundation Research, Guangxi University of Chinese Medicine, 13 Wuhe Road, Qingxiu District, Nanning 530200, ChinaGuangxi Zhuang Yao Medicine Center of Engineering and Technology, Guangxi University of Chinese Medicine, 13 Wuhe Road, Qingxiu District, Nanning 530200, ChinaCAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, ChinaProstate cancer is a common cancer in elderly males. Significant progress has been made in the drug therapies for prostate cancer in recent years. However, side effects are still problems that have not been overcome by the currently used anti-prostate cancer drugs. Novel technologies can be applied to reduce or even eliminate the side effects of drugs. An aptamer may be a sequence of nucleic acids or peptides that can specifically recognize proteins or cells. Taking advantage of this feature, scientists have designed aptamer–drug delivery systems for the development of anti-prostate cancer agents. Theoretically, these aptamer–drug delivery systems can specifically recognize prostate cancer cells and then induce cell death without attacking normal cells. We collected the relevant literature in this field and found that at least nine compounds have been prepared as aptamer–drug delivery systems to evaluate their precise anti-prostate cancer effects. However, the currently studied aptamer–drug delivery systems have not yet entered the market due to defects. Here, we analyze the published data, summarize the characteristics of these delivery systems, and propose ways to promote their application, thus promoting the development of the aptamer–drug delivery systems against prostate cancer.https://www.mdpi.com/1420-3049/27/11/3446aptamerdrug delivery systemsprostate cancerdoxorubicinpaclitaxeldocetaxel |
| spellingShingle | Xueni Wang Qian Zhou Xiaoning Li Xia Gan Peng Liu Xiaotao Feng Gang Fang Yonghong Liu Insights into Aptamer–Drug Delivery Systems against Prostate Cancer Molecules aptamer drug delivery systems prostate cancer doxorubicin paclitaxel docetaxel |
| title | Insights into Aptamer–Drug Delivery Systems against Prostate Cancer |
| title_full | Insights into Aptamer–Drug Delivery Systems against Prostate Cancer |
| title_fullStr | Insights into Aptamer–Drug Delivery Systems against Prostate Cancer |
| title_full_unstemmed | Insights into Aptamer–Drug Delivery Systems against Prostate Cancer |
| title_short | Insights into Aptamer–Drug Delivery Systems against Prostate Cancer |
| title_sort | insights into aptamer drug delivery systems against prostate cancer |
| topic | aptamer drug delivery systems prostate cancer doxorubicin paclitaxel docetaxel |
| url | https://www.mdpi.com/1420-3049/27/11/3446 |
| work_keys_str_mv | AT xueniwang insightsintoaptamerdrugdeliverysystemsagainstprostatecancer AT qianzhou insightsintoaptamerdrugdeliverysystemsagainstprostatecancer AT xiaoningli insightsintoaptamerdrugdeliverysystemsagainstprostatecancer AT xiagan insightsintoaptamerdrugdeliverysystemsagainstprostatecancer AT pengliu insightsintoaptamerdrugdeliverysystemsagainstprostatecancer AT xiaotaofeng insightsintoaptamerdrugdeliverysystemsagainstprostatecancer AT gangfang insightsintoaptamerdrugdeliverysystemsagainstprostatecancer AT yonghongliu insightsintoaptamerdrugdeliverysystemsagainstprostatecancer |