A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy
Abstract Chemodynamic therapy (CDT) has aroused extensive attention for conquering cancers because of its high specificity and low invasiveness. Quick generation of hydroxyl radicals (·OH) during CDT could induce more irreparable damage to cancer cells. The generation rate of ·OH could be magnified...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-01159-x |
| _version_ | 1798025935016951808 |
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| author | Le Zhang Chunjuan Jiang Bing Li Zhengwang Liu Bingxin Gu Simin He Panli Li Yun Sun Shaoli Song |
| author_facet | Le Zhang Chunjuan Jiang Bing Li Zhengwang Liu Bingxin Gu Simin He Panli Li Yun Sun Shaoli Song |
| author_sort | Le Zhang |
| collection | DOAJ |
| description | Abstract Chemodynamic therapy (CDT) has aroused extensive attention for conquering cancers because of its high specificity and low invasiveness. Quick generation of hydroxyl radicals (·OH) during CDT could induce more irreparable damage to cancer cells. The generation rate of ·OH could be magnified via the selection of suitable nanocatalysts or under the assistance of exogenous thermal energy from photothermal therapy (PTT). Here, we construct a kind of monodisperse core-shell Au@Cu2-xSe heterogeneous metal nanoparticles (NPs) for PTT boosted CDT synergistic therapy. Due to the localized surface plasmon resonance (LSPR) coupling effect in the core-shell structure, the photothermal conversion efficiency of Au@Cu2-xSe NPs is up to 56.6%. The in situ generated heat from photothermal can then accelerate the Fenton-like reaction at Cu+ sites to produce abundant ·OH, which will induce apoptotic cell death by attacking DNA, contributing to a heat-boosted CDT. Both in vitro and in vivo results showed that after this synergistic therapy, tumors could be remarkably suppressed. Guided by photoacoustic (PA) and computed tomography (CT) imaging, the therapeutic effects were more specified. Our results revealed that PA and CT dual-imaging-guided PTT boosted CDT synergistic therapy based on core-shell Au@Cu2-xSe NPs is an effective cancer treatment strategy. Graphical Abstract |
| first_indexed | 2024-04-11T18:27:00Z |
| format | Article |
| id | doaj.art-e64c66bb70dc4bdca06d562f545d8e70 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T18:27:00Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-e64c66bb70dc4bdca06d562f545d8e702022-12-22T04:09:36ZengBMCJournal of Nanobiotechnology1477-31552021-12-0119111810.1186/s12951-021-01159-xA core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapyLe Zhang0Chunjuan Jiang1Bing Li2Zhengwang Liu3Bingxin Gu4Simin He5Panli Li6Yun Sun7Shaoli Song8Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer HospitalDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer HospitalDepartment of Research and Development, Shanghai Proton and Heavy Ion CenterDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer HospitalDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer HospitalDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer HospitalDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer HospitalDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer HospitalDepartment of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Fudan University Cancer HospitalAbstract Chemodynamic therapy (CDT) has aroused extensive attention for conquering cancers because of its high specificity and low invasiveness. Quick generation of hydroxyl radicals (·OH) during CDT could induce more irreparable damage to cancer cells. The generation rate of ·OH could be magnified via the selection of suitable nanocatalysts or under the assistance of exogenous thermal energy from photothermal therapy (PTT). Here, we construct a kind of monodisperse core-shell Au@Cu2-xSe heterogeneous metal nanoparticles (NPs) for PTT boosted CDT synergistic therapy. Due to the localized surface plasmon resonance (LSPR) coupling effect in the core-shell structure, the photothermal conversion efficiency of Au@Cu2-xSe NPs is up to 56.6%. The in situ generated heat from photothermal can then accelerate the Fenton-like reaction at Cu+ sites to produce abundant ·OH, which will induce apoptotic cell death by attacking DNA, contributing to a heat-boosted CDT. Both in vitro and in vivo results showed that after this synergistic therapy, tumors could be remarkably suppressed. Guided by photoacoustic (PA) and computed tomography (CT) imaging, the therapeutic effects were more specified. Our results revealed that PA and CT dual-imaging-guided PTT boosted CDT synergistic therapy based on core-shell Au@Cu2-xSe NPs is an effective cancer treatment strategy. Graphical Abstracthttps://doi.org/10.1186/s12951-021-01159-xChemodynamic therapyPhotothermal therapyCore-shell metal nanoparticlesFenton-like reactionTumor imaging |
| spellingShingle | Le Zhang Chunjuan Jiang Bing Li Zhengwang Liu Bingxin Gu Simin He Panli Li Yun Sun Shaoli Song A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy Journal of Nanobiotechnology Chemodynamic therapy Photothermal therapy Core-shell metal nanoparticles Fenton-like reaction Tumor imaging |
| title | A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy |
| title_full | A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy |
| title_fullStr | A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy |
| title_full_unstemmed | A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy |
| title_short | A core-shell Au@Cu2-xSe heterogeneous metal nanocomposite for photoacoustic and computed tomography dual-imaging-guided photothermal boosted chemodynamic therapy |
| title_sort | core shell au cu2 xse heterogeneous metal nanocomposite for photoacoustic and computed tomography dual imaging guided photothermal boosted chemodynamic therapy |
| topic | Chemodynamic therapy Photothermal therapy Core-shell metal nanoparticles Fenton-like reaction Tumor imaging |
| url | https://doi.org/10.1186/s12951-021-01159-x |
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