Pancreatic function in children with non-alcoholic fatty pancreas disease
Objective. To study the features of pancreatic function in children with pancreatic steatosis. Materials and methods. We examined 77 children; the average age of patients was (11.59 ± 2.82) years. Pancreatic steatosis was diagnosed by ultrasound examination. In addition, shear wave elastography o...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporozhye State Medical University
2019-02-01
|
| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/155816/155853 |
| _version_ | 1818515958950526976 |
|---|---|
| author | Yu. M. Stepanov O. Yu. Lukianenko N. Yu. Zavhorodnia O. M. Tatarchuk N. H. Hravirovska I. A. Klenina |
| author_facet | Yu. M. Stepanov O. Yu. Lukianenko N. Yu. Zavhorodnia O. M. Tatarchuk N. H. Hravirovska I. A. Klenina |
| author_sort | Yu. M. Stepanov |
| collection | DOAJ |
| description | Objective. To study the features of pancreatic function in children with pancreatic steatosis.
Materials and methods. We examined 77 children; the average age of patients was (11.59 ± 2.82) years. Pancreatic steatosis was diagnosed by ultrasound examination. In addition, shear wave elastography of the pancreas was performed using UltimaPAExpert apparatus («Radmir»,Ukraine).
Children were divided into groups according to the obesity/overweight and pancreatic steatosis presence as follows: the group 1–- 47 children with pancreatic steatosis and obesity / overweight; the group 2 – 20 children with obesity / overweight without signs of pancreatic steatosis; the group 3 – 10 children with normal weight who had no signs of steatosis. Examination of the exocrine pancreas function with determination of serum amylase, lipase and trypsin levels, urine amylase, fecal elastase was carried out.
Results. Serum lipase level was significantly lower in the group of children with steatosis (0.83 [0.64, 0.99] nmol/s·l) compared to children with normal weight (1.05 [0.99; 1.13] nmol/s·l) (P < 0.05). The level of trypsin did not reveal any significant differences between the groups, while serum amylase level in the patient group 1 tended to be lower compared to children of the group 2. The level of fecal elastase (FE) was significantly lower in patients with steatosis (176.7 [65.8, 251.8] μg/g) compared to children with normal weight (311.40 [213.3, 363. 0] μg/g) (P < 0.05). The level of FE negatively correlated with the degree of pancreatic steatosis in the general group (r = -0,28; P < 0.05) as well as with the pancreatic parenchyma stiffness in children without obesity (r=-0,40; P < 0.05).
Conclusions. Pancreatic steatosis in children can be accompanied by exocrine pancreatic insufficiency development. |
| first_indexed | 2024-12-11T00:35:45Z |
| format | Article |
| id | doaj.art-e6502181a2d04befbcafc8cc6b2cd3f8 |
| institution | Directory Open Access Journal |
| issn | 2306-4145 2310-1210 |
| language | English |
| last_indexed | 2024-12-11T00:35:45Z |
| publishDate | 2019-02-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj.art-e6502181a2d04befbcafc8cc6b2cd3f82022-12-22T01:27:10ZengZaporozhye State Medical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102019-02-01211647110.14739/2310-1210.2019.1.155816Pancreatic function in children with non-alcoholic fatty pancreas diseaseYu. M. StepanovO. Yu. LukianenkoN. Yu. ZavhorodniaO. M. TatarchukN. H. Hravirovska I. A. KleninaObjective. To study the features of pancreatic function in children with pancreatic steatosis. Materials and methods. We examined 77 children; the average age of patients was (11.59 ± 2.82) years. Pancreatic steatosis was diagnosed by ultrasound examination. In addition, shear wave elastography of the pancreas was performed using UltimaPAExpert apparatus («Radmir»,Ukraine). Children were divided into groups according to the obesity/overweight and pancreatic steatosis presence as follows: the group 1–- 47 children with pancreatic steatosis and obesity / overweight; the group 2 – 20 children with obesity / overweight without signs of pancreatic steatosis; the group 3 – 10 children with normal weight who had no signs of steatosis. Examination of the exocrine pancreas function with determination of serum amylase, lipase and trypsin levels, urine amylase, fecal elastase was carried out. Results. Serum lipase level was significantly lower in the group of children with steatosis (0.83 [0.64, 0.99] nmol/s·l) compared to children with normal weight (1.05 [0.99; 1.13] nmol/s·l) (P < 0.05). The level of trypsin did not reveal any significant differences between the groups, while serum amylase level in the patient group 1 tended to be lower compared to children of the group 2. The level of fecal elastase (FE) was significantly lower in patients with steatosis (176.7 [65.8, 251.8] μg/g) compared to children with normal weight (311.40 [213.3, 363. 0] μg/g) (P < 0.05). The level of FE negatively correlated with the degree of pancreatic steatosis in the general group (r = -0,28; P < 0.05) as well as with the pancreatic parenchyma stiffness in children without obesity (r=-0,40; P < 0.05). Conclusions. Pancreatic steatosis in children can be accompanied by exocrine pancreatic insufficiency development.http://zmj.zsmu.edu.ua/article/view/155816/155853pancreatic diseasesexocrine pancreassteatometryelastographyobesitychildren |
| spellingShingle | Yu. M. Stepanov O. Yu. Lukianenko N. Yu. Zavhorodnia O. M. Tatarchuk N. H. Hravirovska I. A. Klenina Pancreatic function in children with non-alcoholic fatty pancreas disease Zaporožskij Medicinskij Žurnal pancreatic diseases exocrine pancreas steatometry elastography obesity children |
| title | Pancreatic function in children with non-alcoholic fatty pancreas disease |
| title_full | Pancreatic function in children with non-alcoholic fatty pancreas disease |
| title_fullStr | Pancreatic function in children with non-alcoholic fatty pancreas disease |
| title_full_unstemmed | Pancreatic function in children with non-alcoholic fatty pancreas disease |
| title_short | Pancreatic function in children with non-alcoholic fatty pancreas disease |
| title_sort | pancreatic function in children with non alcoholic fatty pancreas disease |
| topic | pancreatic diseases exocrine pancreas steatometry elastography obesity children |
| url | http://zmj.zsmu.edu.ua/article/view/155816/155853 |
| work_keys_str_mv | AT yumstepanov pancreaticfunctioninchildrenwithnonalcoholicfattypancreasdisease AT oyulukianenko pancreaticfunctioninchildrenwithnonalcoholicfattypancreasdisease AT nyuzavhorodnia pancreaticfunctioninchildrenwithnonalcoholicfattypancreasdisease AT omtatarchuk pancreaticfunctioninchildrenwithnonalcoholicfattypancreasdisease AT nhhravirovska pancreaticfunctioninchildrenwithnonalcoholicfattypancreasdisease AT iaklenina pancreaticfunctioninchildrenwithnonalcoholicfattypancreasdisease |