Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology
Abstract Background In human medicine, congenital maljunction of the common bile duct (CBD) and main pancreatic duct (MPD), or pancreatobiliary maljunction (PBM), is a known cause of cholecystitis. Objective Pancreatic enzyme activity in the bile (a diagnostic marker for PBM) of healthy cats was mea...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-07-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.16196 |
| _version_ | 1818439207288307712 |
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| author | Shinsuke Fujimoto Shidow Torisu Yasuyuki Kaneko Shinya Mizutani Shushi Yamamoto Kiyokazu Naganobu Kensuke Nakamura |
| author_facet | Shinsuke Fujimoto Shidow Torisu Yasuyuki Kaneko Shinya Mizutani Shushi Yamamoto Kiyokazu Naganobu Kensuke Nakamura |
| author_sort | Shinsuke Fujimoto |
| collection | DOAJ |
| description | Abstract Background In human medicine, congenital maljunction of the common bile duct (CBD) and main pancreatic duct (MPD), or pancreatobiliary maljunction (PBM), is a known cause of cholecystitis. Objective Pancreatic enzyme activity in the bile (a diagnostic marker for PBM) of healthy cats was measured to determine normal values and evaluate its relationship with biliary morphology. Animals Fifty‐two healthy cats. Methods Cross‐sectional study of the biliary tracts of healthy cats during laparoscopic ovariohysterectomy and measurement of pancreatic enzyme activity in bile. The cats were divided into groups A and B based on the ratio of the diameter of the cystic duct (CD) to the CBD. The normal ratio was 3.4. Pancreatic enzyme activity in bile was compared between the groups. Results The CBDs were straight in all cases, whereas the CDs were variably tortuous or dilated. Amylase activity in the bile (median, <100 U/L; range, <100‐591 U/L) was lower than in serum in all cases, and group B, which had a CD/CBD ratio >3.4, had significantly higher amylase activity (median, 109 U/L; range, <100‐591 U/L) in the bile than did group A (median, <100 U/L; range, <100‐238 U/L), which had a CD/CBD ratio <3.4 (P = .0009). Conclusions and Clinical Importance The results suggest that a dilated CD is associated with reflux of pancreatic juice. In the future, it will be necessary to examine the clinical usefulness of these findings by measuring pancreatic enzyme activity in the bile of cats with cholangitis. |
| first_indexed | 2024-12-14T17:52:47Z |
| format | Article |
| id | doaj.art-e6505567e72d41dc8ba478c30041bd18 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-14T17:52:47Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-e6505567e72d41dc8ba478c30041bd182022-12-21T22:52:37ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762021-07-013541780178810.1111/jvim.16196Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphologyShinsuke Fujimoto0Shidow Torisu1Yasuyuki Kaneko2Shinya Mizutani3Shushi Yamamoto4Kiyokazu Naganobu5Kensuke Nakamura6Miyazaki University Veterinary Medical Teaching Hospital Laboratory 1‐1 Gakuenkibanadainishi Miyazaki City Miyazaki Prefecture JapanLaboratory of Companion Animal Surgery, Department of Companion Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.Miyazaki University Veterinary Medical Teaching Hospital Laboratory 1‐1 Gakuenkibanadainishi Miyazaki City Miyazaki Prefecture JapanMiyazaki University Veterinary Medical Teaching Hospital Laboratory 1‐1 Gakuenkibanadainishi Miyazaki City Miyazaki Prefecture JapanMiyazaki University Veterinary Medical Teaching Hospital Laboratory 1‐1 Gakuenkibanadainishi Miyazaki City Miyazaki Prefecture JapanMiyazaki University Veterinary Medical Teaching Hospital Laboratory 1‐1 Gakuenkibanadainishi Miyazaki City Miyazaki Prefecture JapanLaboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences Graduate School of Veterinary Medicine, Hokkaido University 18‐9 Kita, Kita Ward, Sapporo Hokkaido JapanAbstract Background In human medicine, congenital maljunction of the common bile duct (CBD) and main pancreatic duct (MPD), or pancreatobiliary maljunction (PBM), is a known cause of cholecystitis. Objective Pancreatic enzyme activity in the bile (a diagnostic marker for PBM) of healthy cats was measured to determine normal values and evaluate its relationship with biliary morphology. Animals Fifty‐two healthy cats. Methods Cross‐sectional study of the biliary tracts of healthy cats during laparoscopic ovariohysterectomy and measurement of pancreatic enzyme activity in bile. The cats were divided into groups A and B based on the ratio of the diameter of the cystic duct (CD) to the CBD. The normal ratio was 3.4. Pancreatic enzyme activity in bile was compared between the groups. Results The CBDs were straight in all cases, whereas the CDs were variably tortuous or dilated. Amylase activity in the bile (median, <100 U/L; range, <100‐591 U/L) was lower than in serum in all cases, and group B, which had a CD/CBD ratio >3.4, had significantly higher amylase activity (median, 109 U/L; range, <100‐591 U/L) in the bile than did group A (median, <100 U/L; range, <100‐238 U/L), which had a CD/CBD ratio <3.4 (P = .0009). Conclusions and Clinical Importance The results suggest that a dilated CD is associated with reflux of pancreatic juice. In the future, it will be necessary to examine the clinical usefulness of these findings by measuring pancreatic enzyme activity in the bile of cats with cholangitis.https://doi.org/10.1111/jvim.16196cholangitiscystic ductpancreatic enzyme activity in bilepancreatobiliary maljunction |
| spellingShingle | Shinsuke Fujimoto Shidow Torisu Yasuyuki Kaneko Shinya Mizutani Shushi Yamamoto Kiyokazu Naganobu Kensuke Nakamura Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology Journal of Veterinary Internal Medicine cholangitis cystic duct pancreatic enzyme activity in bile pancreatobiliary maljunction |
| title | Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology |
| title_full | Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology |
| title_fullStr | Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology |
| title_full_unstemmed | Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology |
| title_short | Pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology |
| title_sort | pancreatic enzyme activity in the bile of healthy cats and its association with biliary morphology |
| topic | cholangitis cystic duct pancreatic enzyme activity in bile pancreatobiliary maljunction |
| url | https://doi.org/10.1111/jvim.16196 |
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