The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors
Vascular endothelial cells regulate arterial tone through the release of nitric oxide and other diffusible factors such as prostacyclin and endothelium derived hyperpolarizing factors. Alongside these diffusible factors, contact-mediated electrical propagation from endothelial cells to smooth muscle...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.728979/full |
| _version_ | 1819113599032885248 |
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| author | Kenichi Goto Takanari Kitazono |
| author_facet | Kenichi Goto Takanari Kitazono |
| author_sort | Kenichi Goto |
| collection | DOAJ |
| description | Vascular endothelial cells regulate arterial tone through the release of nitric oxide and other diffusible factors such as prostacyclin and endothelium derived hyperpolarizing factors. Alongside these diffusible factors, contact-mediated electrical propagation from endothelial cells to smooth muscle cells via myoendothelial gap junctions, termed endothelium-dependent hyperpolarization (EDH), plays a critical role in endothelium-dependent vasodilation in certain vascular beds. A rise in intracellular Ca2+ concentration in endothelial cells is a prerequisite for both the production of diffusible factors and the generation of EDH, and Ca2+ influx through the endothelial transient receptor potential vanilloid 4 (TRPV4) ion channel, a nonselective cation channel of the TRP family, plays a critical role in this process in various vascular beds. Emerging evidence suggests that the dysregulation of endothelial TRPV4 channels underpins endothelial dysfunction associated with cardiovascular disease (CVD) risk factors, including hypertension, obesity, diabetes, and aging. Because endothelial dysfunction is a precursor to CVD, a better understanding of the mechanisms underlying impaired TRPV4 channels could lead to novel therapeutic strategies for CVD prevention. In this mini review, we present the current knowledge of the pathophysiological changes in endothelial TRPV4 channels associated with CVD risk factors, and then explore the underlying mechanisms involved. |
| first_indexed | 2024-12-22T04:31:58Z |
| format | Article |
| id | doaj.art-e651233ae70b4c0aaa33a536d60818c5 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T04:31:58Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e651233ae70b4c0aaa33a536d60818c52022-12-21T18:39:00ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-09-011210.3389/fphys.2021.728979728979The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk FactorsKenichi Goto0Takanari Kitazono1Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanVascular endothelial cells regulate arterial tone through the release of nitric oxide and other diffusible factors such as prostacyclin and endothelium derived hyperpolarizing factors. Alongside these diffusible factors, contact-mediated electrical propagation from endothelial cells to smooth muscle cells via myoendothelial gap junctions, termed endothelium-dependent hyperpolarization (EDH), plays a critical role in endothelium-dependent vasodilation in certain vascular beds. A rise in intracellular Ca2+ concentration in endothelial cells is a prerequisite for both the production of diffusible factors and the generation of EDH, and Ca2+ influx through the endothelial transient receptor potential vanilloid 4 (TRPV4) ion channel, a nonselective cation channel of the TRP family, plays a critical role in this process in various vascular beds. Emerging evidence suggests that the dysregulation of endothelial TRPV4 channels underpins endothelial dysfunction associated with cardiovascular disease (CVD) risk factors, including hypertension, obesity, diabetes, and aging. Because endothelial dysfunction is a precursor to CVD, a better understanding of the mechanisms underlying impaired TRPV4 channels could lead to novel therapeutic strategies for CVD prevention. In this mini review, we present the current knowledge of the pathophysiological changes in endothelial TRPV4 channels associated with CVD risk factors, and then explore the underlying mechanisms involved.https://www.frontiersin.org/articles/10.3389/fphys.2021.728979/fullendothelial dysfunctiontransient receptor potential vanilloid type 4 channelendothelium-dependent hyperpolarizationnitric oxidehypertensionobesity |
| spellingShingle | Kenichi Goto Takanari Kitazono The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors Frontiers in Physiology endothelial dysfunction transient receptor potential vanilloid type 4 channel endothelium-dependent hyperpolarization nitric oxide hypertension obesity |
| title | The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors |
| title_full | The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors |
| title_fullStr | The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors |
| title_full_unstemmed | The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors |
| title_short | The Transient Receptor Potential Vanilloid 4 Channel and Cardiovascular Disease Risk Factors |
| title_sort | transient receptor potential vanilloid 4 channel and cardiovascular disease risk factors |
| topic | endothelial dysfunction transient receptor potential vanilloid type 4 channel endothelium-dependent hyperpolarization nitric oxide hypertension obesity |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.728979/full |
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