Sirtuin-1 in Egyptian patients with coronary artery disease
Abstract Background Coronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma le...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-11-01
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| Series: | Beni-Suef University Journal of Basic and Applied Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43088-021-00164-1 |
| _version_ | 1818983656635498496 |
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| author | AL-Shabrawy M. Abdelnabi Imam M. Esmayel Samia Hussein Reham M. Ali Alhoussein Alsayed AbdelAal |
| author_facet | AL-Shabrawy M. Abdelnabi Imam M. Esmayel Samia Hussein Reham M. Ali Alhoussein Alsayed AbdelAal |
| author_sort | AL-Shabrawy M. Abdelnabi |
| collection | DOAJ |
| description | Abstract Background Coronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma level of SIRT1 in patients with CAD and explore its correlation with cardiovascular risk factors. Results Plasma SIRT1 was significantly lower in patients with chronic coronary syndrome (CCS) than in those in the control group and was significantly lower in patients with both acute myocardial infarction and unstable angina than in those in the control group and with CCS. Moreover, plasma SIRT1 was positively correlated with platelet count and negatively correlated with cholesterol and triglyceride levels. Conclusions The plasma level of SIRT1 is lower in patients with CAD compared to control and it could be a possible marker for this disease. Multi-center studies with follow-up measurements are recommended for further investigation. |
| first_indexed | 2024-12-20T18:06:35Z |
| format | Article |
| id | doaj.art-e652993945ae42759ca3b39c90f5dcb2 |
| institution | Directory Open Access Journal |
| issn | 2314-8543 |
| language | English |
| last_indexed | 2024-12-20T18:06:35Z |
| publishDate | 2021-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Beni-Suef University Journal of Basic and Applied Sciences |
| spelling | doaj.art-e652993945ae42759ca3b39c90f5dcb22022-12-21T19:30:34ZengSpringerOpenBeni-Suef University Journal of Basic and Applied Sciences2314-85432021-11-011011710.1186/s43088-021-00164-1Sirtuin-1 in Egyptian patients with coronary artery diseaseAL-Shabrawy M. Abdelnabi0Imam M. Esmayel1Samia Hussein2Reham M. Ali3Alhoussein Alsayed AbdelAal4Internal Medicine Department, Faculty of Medicine, Zagazig UniversityInternal Medicine Department, Faculty of Medicine, Zagazig UniversityMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig UniversityInternal Medicine Department, Faculty of Medicine, Zagazig UniversityInternal Medicine Department, Faculty of Medicine, Zagazig UniversityAbstract Background Coronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma level of SIRT1 in patients with CAD and explore its correlation with cardiovascular risk factors. Results Plasma SIRT1 was significantly lower in patients with chronic coronary syndrome (CCS) than in those in the control group and was significantly lower in patients with both acute myocardial infarction and unstable angina than in those in the control group and with CCS. Moreover, plasma SIRT1 was positively correlated with platelet count and negatively correlated with cholesterol and triglyceride levels. Conclusions The plasma level of SIRT1 is lower in patients with CAD compared to control and it could be a possible marker for this disease. Multi-center studies with follow-up measurements are recommended for further investigation.https://doi.org/10.1186/s43088-021-00164-1AtherosclerosisCoronary heart diseaseSirtuin |
| spellingShingle | AL-Shabrawy M. Abdelnabi Imam M. Esmayel Samia Hussein Reham M. Ali Alhoussein Alsayed AbdelAal Sirtuin-1 in Egyptian patients with coronary artery disease Beni-Suef University Journal of Basic and Applied Sciences Atherosclerosis Coronary heart disease Sirtuin |
| title | Sirtuin-1 in Egyptian patients with coronary artery disease |
| title_full | Sirtuin-1 in Egyptian patients with coronary artery disease |
| title_fullStr | Sirtuin-1 in Egyptian patients with coronary artery disease |
| title_full_unstemmed | Sirtuin-1 in Egyptian patients with coronary artery disease |
| title_short | Sirtuin-1 in Egyptian patients with coronary artery disease |
| title_sort | sirtuin 1 in egyptian patients with coronary artery disease |
| topic | Atherosclerosis Coronary heart disease Sirtuin |
| url | https://doi.org/10.1186/s43088-021-00164-1 |
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