Liquid Biopsy with Detection of NRAS<sup>Q61K</sup> Mutation in Cerebrospinal Fluid: An Alternative Tool for the Diagnosis of Primary Pediatric Leptomeningeal Melanoma

Liquid Biopsy with Detection of NRAS<sup>Q61K</sup> Mutation in Cerebrospinal Fluid: An Alternative Tool for the Diagnosis of Primary Pediatric Leptomeningeal Melanoma

Primary leptomeningeal melanoma (PLMM) is a very rare disease in childhood with a poor prognosis. NRAS<sup>Q16K</sup> mutation frequently drives malignant transformation in this population, so its evaluation should be considered in childhood PLMM diagnosis. In the presented case, the mut...

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Bibliographic Details
Main Authors: Angela Mastronuzzi, Francesco Fabozzi, Martina Rinelli, Rita De Vito, Emanuele Agolini, Giovanna Stefania Colafati, Antonella Cacchione, Andrea Carai, Maria Antonietta De Ioris
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Diagnostics
Subjects:
leptomeningeal melanoma
children
liquid biopsy
NRAS<sup>Q61K</sup>
Online Access:https://www.mdpi.com/2075-4418/12/7/1609

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