Oct4-dependent FoxC1 activation improves the survival and neovascularization of mesenchymal stem cells under myocardial ischemia

Oct4-dependent FoxC1 activation improves the survival and neovascularization of mesenchymal stem cells under myocardial ischemia

Abstract Background The administration of mesenchymal stem cells (MSCs) remains the most promising approach for cardiac repair after myocardial infarct (MI). However, their poor survival and potential in the ischemic environment limit their therapeutic efficacy for heart repair after MI. The purpose...

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Bibliographic Details
Main Authors: Zhou Ji, Songsheng Chen, Jin Cui, Weiguang Huang, Rui Zhang, Jianrui Wei, Shaoheng Zhang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
FoxC1
Mesenchymal stem cells
Niche
Hypoxic
Oct4
Angiogenesis
Online Access:https://doi.org/10.1186/s13287-021-02553-w

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