Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction [version 2; peer review: 1 approved, 2 approved with reservations]
Background: Vestibular dysfunction is known to affect cognitive abilities related to the processing of spatial and non-spatial information. P300 is an event-related potential (ERP) used to assess cognitive function. Studies have shown abnormalities in P300 in individuals with vestibular hypofunction...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2022-11-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/11-1013/v2 |
| _version_ | 1827860273459888128 |
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| author | Mohan Kumar Kalaiah Deviprasad D Krishnapriya S Anupriya Ebenezer Kaushlendra Kumar |
| author_facet | Mohan Kumar Kalaiah Deviprasad D Krishnapriya S Anupriya Ebenezer Kaushlendra Kumar |
| author_sort | Mohan Kumar Kalaiah |
| collection | DOAJ |
| description | Background: Vestibular dysfunction is known to affect cognitive abilities related to the processing of spatial and non-spatial information. P300 is an event-related potential (ERP) used to assess cognitive function. Studies have shown abnormalities in P300 in individuals with vestibular hypofunction. However, the literature shows equivocal findings for P300 in individuals with vestibular dysfunction. The aim of present study was to compare the latency and amplitude of cortical auditory evoked potential and P300 between individuals with vestibular dysfunction and individuals with no vestibular dysfunction. Methods: Forty adults with a mean age of 40.5 years participated in the study. Group I included 20 adults diagnosed with vestibular dysfunction and group II included 20 age-matched adults with no vestibular dysfunction. The P300 was recorded using pure-tones in an odd-ball paradigm, from electrode sites Cz and Pz. The latency and amplitude of peaks P1, N1, P2, N2 P300, and N4 were measured. Results: The results showed no significant difference in the latency and amplitude of peaks P1, N1, P2, and N2 of the cortical auditory potentials between groups. The P300 was absent in approximately 30% of individuals with vestibular dysfunction meanwhile, it was present in all individuals in group II. The mean latency and amplitude of the P300 and latency of N4 were not significantly different between the groups. However, a significant difference was observed in N4 amplitude between groups at both electrode sites. And, no correlation was observed between the DHI score and the P300 parameters in group I. Conclusions: the P300 was absent in a greater number of individuals with vestibular dysfunction, suggesting cognitive impairment. However, when the P300 was present the peak latency and amplitude showed no significant difference in both groups. |
| first_indexed | 2024-03-12T13:20:54Z |
| format | Article |
| id | doaj.art-e653192e753a45e8b9f7d9aef5d6911f |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-03-12T13:20:54Z |
| publishDate | 2022-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-e653192e753a45e8b9f7d9aef5d6911f2023-08-26T00:00:01ZengF1000 Research LtdF1000Research2046-14022022-11-0111140797Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction [version 2; peer review: 1 approved, 2 approved with reservations]Mohan Kumar Kalaiah0https://orcid.org/0000-0001-9984-9175Deviprasad D1Krishnapriya S2Anupriya Ebenezer3Kaushlendra Kumar4Department of Audiology and Speech Language Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Otorhinolaryngology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Audiology and Speech Language Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Audiology and Speech Language Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, IndiaDepartment of Audiology and Speech Language Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, IndiaBackground: Vestibular dysfunction is known to affect cognitive abilities related to the processing of spatial and non-spatial information. P300 is an event-related potential (ERP) used to assess cognitive function. Studies have shown abnormalities in P300 in individuals with vestibular hypofunction. However, the literature shows equivocal findings for P300 in individuals with vestibular dysfunction. The aim of present study was to compare the latency and amplitude of cortical auditory evoked potential and P300 between individuals with vestibular dysfunction and individuals with no vestibular dysfunction. Methods: Forty adults with a mean age of 40.5 years participated in the study. Group I included 20 adults diagnosed with vestibular dysfunction and group II included 20 age-matched adults with no vestibular dysfunction. The P300 was recorded using pure-tones in an odd-ball paradigm, from electrode sites Cz and Pz. The latency and amplitude of peaks P1, N1, P2, N2 P300, and N4 were measured. Results: The results showed no significant difference in the latency and amplitude of peaks P1, N1, P2, and N2 of the cortical auditory potentials between groups. The P300 was absent in approximately 30% of individuals with vestibular dysfunction meanwhile, it was present in all individuals in group II. The mean latency and amplitude of the P300 and latency of N4 were not significantly different between the groups. However, a significant difference was observed in N4 amplitude between groups at both electrode sites. And, no correlation was observed between the DHI score and the P300 parameters in group I. Conclusions: the P300 was absent in a greater number of individuals with vestibular dysfunction, suggesting cognitive impairment. However, when the P300 was present the peak latency and amplitude showed no significant difference in both groups.https://f1000research.com/articles/11-1013/v2cognition vestibular dysfunction vertigo P300 dizziness event related potentialseng |
| spellingShingle | Mohan Kumar Kalaiah Deviprasad D Krishnapriya S Anupriya Ebenezer Kaushlendra Kumar Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction [version 2; peer review: 1 approved, 2 approved with reservations] F1000Research cognition vestibular dysfunction vertigo P300 dizziness event related potentials eng |
| title | Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full | Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_short | Cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_sort | cortical auditory potentials and cognitive potentials in individuals with and without vestibular dysfunction version 2 peer review 1 approved 2 approved with reservations |
| topic | cognition vestibular dysfunction vertigo P300 dizziness event related potentials eng |
| url | https://f1000research.com/articles/11-1013/v2 |
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