The protein and lipid peroxidation and antioxidant system in patients with HIV/AIDS-associated newly diagnosed pulmonary tuberculosis depending on the severity of immunodeficiency, clinical and radiological changes
Aim. The clinical, radiological and immunological aspects of co-infection are actively studied nowadays. To identify the peculiarities of oxidative status in patients with HIV/AIDS-associated pulmonary tuberculosis depending on the severity of immunosuppression, and clinical and radiological data 47...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zaporozhye State Medical University
2014-06-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/26031/23505 |
| Summary: | Aim. The clinical, radiological and immunological aspects of co-infection are actively studied nowadays. To identify the peculiarities of oxidative status in patients with HIV/AIDS-associated pulmonary tuberculosis depending on the severity of immunosuppression, and clinical and radiological data 47 patients were examined.
Methods and results. Protein peroxidation products were determined with the method by B. Halliwell, lipid peroxidation – with method by V.B. Gavrilov, catalase activity - M.A. Koroljuk method, SOD activity – by B. Haglof. Patients with HIV/AIDS-associated newly diagnosed pulmonary tuberculosis had mostly marked increase in levels of 254 nm intermediate mass molecules at immunodeficiency.
Conclusion. Rise of protein peroxidation products levels and the decrease of catalase activity at extensive pulmonary or severe extrapulmonary lesions and in cases with multiple organs dysfunction were determined too. |
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| ISSN: | 2306-4145 2310-1210 |