Effect of trigger day serum luteinising hormone levels on the in-vitro fertilization outcome: an observational study
Objective Controlled ovarian stimulation leads to profound changes in the endocrine characteristics of the ovarian cycle. Serum luteinising hormone (LH) levels on the day of trigger have been shown to correlate with oocyte quality and pregnancy rate in antagonist cycles. Methods This is an observati...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Obstetrics and Gynecology
2024-03-01
|
| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://ogscience.org/upload/pdf/ogs-23215.pdf |
| _version_ | 1797261943222829056 |
|---|---|
| author | Harpreet Kaur Gautham T Pranesh Vyshnavi Rao Kamini A Rao |
| author_facet | Harpreet Kaur Gautham T Pranesh Vyshnavi Rao Kamini A Rao |
| author_sort | Harpreet Kaur |
| collection | DOAJ |
| description | Objective Controlled ovarian stimulation leads to profound changes in the endocrine characteristics of the ovarian cycle. Serum luteinising hormone (LH) levels on the day of trigger have been shown to correlate with oocyte quality and pregnancy rate in antagonist cycles. Methods This is an observational study of 86 women undergoing an antagonist in-vitro fertilisation cycle. Oocyte maturation trigger used was either Inj. human chorionic gonadotropin or Inj. triptorelin 0.2 mg s/c or a combination of both. Women were categorised into four groups based on serum LH levels on the day of trigger i.e., LH ≤0.5 (n=8), LH=0.6–1.0 international units (IU)/L (n=12), LH=1.0–1.5 IU/L (n=13), and LH >1.6 IU/L (n=53) and the subgroup analysis was done based on type of trigger used. Results Mature oocyte (MII) retrieval rate did not show a significant relation with serum LH levels (87%, 89%, 77%, and 76% in groups with LH <0.5, 0.5–1.0, 1.0–1.5, and >1.5 IU/L respectively; P-value=0.243). There was no significant difference in the clinical pregnancy rate either when women were split according to the type of trigger given or according to trigger day LH levels. Women with low LH levels (<0.5 IU/L) required significantly more doses of gonadotropins compared to women with LH levels of 1.0–1.5 IU/L. (3,531+1,133 vs. 2,281+938; P-value=0.01). Conclusion Based on the observation from the current study, there was no significant association of serum LH levels with MII retrieval rate and clinical pregnancy rate. The group with low LH levels required slightly longer days of stimulation. |
| first_indexed | 2024-04-24T23:49:15Z |
| format | Article |
| id | doaj.art-e6553839cb7d41279f05306f4b0402dd |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-04-24T23:49:15Z |
| publishDate | 2024-03-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-e6553839cb7d41279f05306f4b0402dd2024-03-15T02:07:37ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802024-03-0167223524210.5468/ogs.232158807Effect of trigger day serum luteinising hormone levels on the in-vitro fertilization outcome: an observational studyHarpreet Kaur0Gautham T Pranesh1Vyshnavi Rao2Kamini A Rao3 Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Bilaspur, India Consultant Biochemistry and COO, Medline Academics, Bangalore, India Consultant Reproductive Medicine, Milann Fertility Center, Medline Academics, Bangalore, India Department of Reproductive Medicine, Medline Academics, Bangalore, IndiaObjective Controlled ovarian stimulation leads to profound changes in the endocrine characteristics of the ovarian cycle. Serum luteinising hormone (LH) levels on the day of trigger have been shown to correlate with oocyte quality and pregnancy rate in antagonist cycles. Methods This is an observational study of 86 women undergoing an antagonist in-vitro fertilisation cycle. Oocyte maturation trigger used was either Inj. human chorionic gonadotropin or Inj. triptorelin 0.2 mg s/c or a combination of both. Women were categorised into four groups based on serum LH levels on the day of trigger i.e., LH ≤0.5 (n=8), LH=0.6–1.0 international units (IU)/L (n=12), LH=1.0–1.5 IU/L (n=13), and LH >1.6 IU/L (n=53) and the subgroup analysis was done based on type of trigger used. Results Mature oocyte (MII) retrieval rate did not show a significant relation with serum LH levels (87%, 89%, 77%, and 76% in groups with LH <0.5, 0.5–1.0, 1.0–1.5, and >1.5 IU/L respectively; P-value=0.243). There was no significant difference in the clinical pregnancy rate either when women were split according to the type of trigger given or according to trigger day LH levels. Women with low LH levels (<0.5 IU/L) required significantly more doses of gonadotropins compared to women with LH levels of 1.0–1.5 IU/L. (3,531+1,133 vs. 2,281+938; P-value=0.01). Conclusion Based on the observation from the current study, there was no significant association of serum LH levels with MII retrieval rate and clinical pregnancy rate. The group with low LH levels required slightly longer days of stimulation.http://ogscience.org/upload/pdf/ogs-23215.pdf fertilizationluteinising hormonemature ovapregnancy outcome |
| spellingShingle | Harpreet Kaur Gautham T Pranesh Vyshnavi Rao Kamini A Rao Effect of trigger day serum luteinising hormone levels on the in-vitro fertilization outcome: an observational study Obstetrics & Gynecology Science fertilization luteinising hormone mature ova pregnancy outcome |
| title | Effect of trigger day serum luteinising hormone levels on the in-vitro fertilization outcome: an observational study |
| title_full | Effect of trigger day serum luteinising hormone levels on the in-vitro fertilization outcome: an observational study |
| title_fullStr | Effect of trigger day serum luteinising hormone levels on the in-vitro fertilization outcome: an observational study |
| title_full_unstemmed | Effect of trigger day serum luteinising hormone levels on the in-vitro fertilization outcome: an observational study |
| title_short | Effect of trigger day serum luteinising hormone levels on the in-vitro fertilization outcome: an observational study |
| title_sort | effect of trigger day serum luteinising hormone levels on the in vitro fertilization outcome an observational study |
| topic | fertilization luteinising hormone mature ova pregnancy outcome |
| url | http://ogscience.org/upload/pdf/ogs-23215.pdf |
| work_keys_str_mv | AT harpreetkaur effectoftriggerdayserumluteinisinghormonelevelsontheinvitrofertilizationoutcomeanobservationalstudy AT gauthamtpranesh effectoftriggerdayserumluteinisinghormonelevelsontheinvitrofertilizationoutcomeanobservationalstudy AT vyshnavirao effectoftriggerdayserumluteinisinghormonelevelsontheinvitrofertilizationoutcomeanobservationalstudy AT kaminiarao effectoftriggerdayserumluteinisinghormonelevelsontheinvitrofertilizationoutcomeanobservationalstudy |