ABATACEPT: A NEW CHOICE FOR CHILDREN WITH POLYARTICULAR COURSE JUVENILE IDIOPATHIC ARTHRITIS
<strong><em></em></strong><em>Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disorder in children. Children with polyarticular curse JIA, who do not respond to non-steroidal anti-inflammatory drugs and steroid injections, are treated with disea...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
"Paediatrician" Publishers LLC
2010-01-01
|
| Series: | Вопросы современной педиатрии |
| Online Access: | http://vsp.spr-journal.ru:80/jour/article/view/602 |
| _version_ | 1797722165745811456 |
|---|---|
| author | N. Ruperto |
| author_facet | N. Ruperto |
| author_sort | N. Ruperto |
| collection | DOAJ |
| description | <strong><em></em></strong><em>Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disorder in children. Children with polyarticular curse JIA, who do not respond to non-steroidal anti-inflammatory drugs and steroid injections, are treated with disease modyfing anti-rheumatic drugs with the first choice being methotrexate (MTX). For children not responding or intolerant to MTX, different therapeutic modalities with the so-called biologic agents, such as anti-tumor necrosis factor (TNF), are now available. However, a certain proportion of children with JIA, do not respond or are intolerant to anti-TNF therapy. This review summarises the available evidence related to the safety and efficacy profile of abatacept, a new selective co-stimulation modulator, for the treatment of polyarticular course JIA.</em><strong><em><br /><strong><em>Key words: children, juvenile idiopathic arthritis, juvenile rheumatoid arthritis, abatacept, inactive disease status, T-cell co-stimulation.</em></strong><br /></em></strong><em><span style="text-decoration: underline;"><em>(<em><em>Voprosy sovremennoi pediatrii — </em></em>Current Pediatrics. 2010;9(2):<em>32-39</em>)</em></span></em> |
| first_indexed | 2024-03-12T09:44:36Z |
| format | Article |
| id | doaj.art-e657affba9954ad8b01693c9137fcbc4 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T09:44:36Z |
| publishDate | 2010-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-e657affba9954ad8b01693c9137fcbc42023-09-02T13:03:01Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352010-01-01923239602ABATACEPT: A NEW CHOICE FOR CHILDREN WITH POLYARTICULAR COURSE JUVENILE IDIOPATHIC ARTHRITISN. Ruperto0Pediatric Rheumatology International Trials Organisation (PRINTO)<strong><em></em></strong><em>Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disorder in children. Children with polyarticular curse JIA, who do not respond to non-steroidal anti-inflammatory drugs and steroid injections, are treated with disease modyfing anti-rheumatic drugs with the first choice being methotrexate (MTX). For children not responding or intolerant to MTX, different therapeutic modalities with the so-called biologic agents, such as anti-tumor necrosis factor (TNF), are now available. However, a certain proportion of children with JIA, do not respond or are intolerant to anti-TNF therapy. This review summarises the available evidence related to the safety and efficacy profile of abatacept, a new selective co-stimulation modulator, for the treatment of polyarticular course JIA.</em><strong><em><br /><strong><em>Key words: children, juvenile idiopathic arthritis, juvenile rheumatoid arthritis, abatacept, inactive disease status, T-cell co-stimulation.</em></strong><br /></em></strong><em><span style="text-decoration: underline;"><em>(<em><em>Voprosy sovremennoi pediatrii — </em></em>Current Pediatrics. 2010;9(2):<em>32-39</em>)</em></span></em>http://vsp.spr-journal.ru:80/jour/article/view/602 |
| spellingShingle | N. Ruperto ABATACEPT: A NEW CHOICE FOR CHILDREN WITH POLYARTICULAR COURSE JUVENILE IDIOPATHIC ARTHRITIS Вопросы современной педиатрии |
| title | ABATACEPT: A NEW CHOICE FOR CHILDREN WITH POLYARTICULAR COURSE JUVENILE IDIOPATHIC ARTHRITIS |
| title_full | ABATACEPT: A NEW CHOICE FOR CHILDREN WITH POLYARTICULAR COURSE JUVENILE IDIOPATHIC ARTHRITIS |
| title_fullStr | ABATACEPT: A NEW CHOICE FOR CHILDREN WITH POLYARTICULAR COURSE JUVENILE IDIOPATHIC ARTHRITIS |
| title_full_unstemmed | ABATACEPT: A NEW CHOICE FOR CHILDREN WITH POLYARTICULAR COURSE JUVENILE IDIOPATHIC ARTHRITIS |
| title_short | ABATACEPT: A NEW CHOICE FOR CHILDREN WITH POLYARTICULAR COURSE JUVENILE IDIOPATHIC ARTHRITIS |
| title_sort | abatacept a new choice for children with polyarticular course juvenile idiopathic arthritis |
| url | http://vsp.spr-journal.ru:80/jour/article/view/602 |
| work_keys_str_mv | AT nruperto abataceptanewchoiceforchildrenwithpolyarticularcoursejuvenileidiopathicarthritis |