The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases
Tenascins are a family of multifunctional extracellular matrix (ECM) glycoproteins with time- and tissue specific expression patterns during development, tissue homeostasis, and diseases. There are four family members (tenascin-C, -R, -X, -W) in vertebrates. Among them, tenascin-X (TNX) and tenascin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.609752/full |
| _version_ | 1818432715920244736 |
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| author | Ken-ichi Matsumoto Hiroki Aoki |
| author_facet | Ken-ichi Matsumoto Hiroki Aoki |
| author_sort | Ken-ichi Matsumoto |
| collection | DOAJ |
| description | Tenascins are a family of multifunctional extracellular matrix (ECM) glycoproteins with time- and tissue specific expression patterns during development, tissue homeostasis, and diseases. There are four family members (tenascin-C, -R, -X, -W) in vertebrates. Among them, tenascin-X (TNX) and tenascin-C (TNC) play important roles in human pathologies. TNX is expressed widely in loose connective tissues. TNX contributes to the stability and maintenance of the collagen network, and its absence causes classical-like Ehlers-Danlos syndrome (clEDS), a heritable connective tissue disorder. In contrast, TNC is specifically and transiently expressed upon pathological conditions such as inflammation, fibrosis, and cancer. There is growing evidence that TNC is involved in inflammatory processes with proinflammatory or anti-inflammatory activity in a context-dependent manner. In this review, we summarize the roles of these two tenascins, TNX and TNC, in cardiovascular and inflammatory diseases and in clEDS, and we discuss the functional consequences of the expression of these tenascins for tissue homeostasis. |
| first_indexed | 2024-12-14T16:09:37Z |
| format | Article |
| id | doaj.art-e6584bada6b446b29f07b9091f7cc907 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T16:09:37Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e6584bada6b446b29f07b9091f7cc9072022-12-21T22:55:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-12-011110.3389/fimmu.2020.609752609752The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue DiseasesKen-ichi Matsumoto0Hiroki Aoki1Department of Biosignaling and Radioisotope Experiment, Interdisciplinary Center for Science Research, Organization for Research and Academic Information, Shimane University, Izumo, JapanCardiovascular Research Institute, Kurume University, Kurume, JapanTenascins are a family of multifunctional extracellular matrix (ECM) glycoproteins with time- and tissue specific expression patterns during development, tissue homeostasis, and diseases. There are four family members (tenascin-C, -R, -X, -W) in vertebrates. Among them, tenascin-X (TNX) and tenascin-C (TNC) play important roles in human pathologies. TNX is expressed widely in loose connective tissues. TNX contributes to the stability and maintenance of the collagen network, and its absence causes classical-like Ehlers-Danlos syndrome (clEDS), a heritable connective tissue disorder. In contrast, TNC is specifically and transiently expressed upon pathological conditions such as inflammation, fibrosis, and cancer. There is growing evidence that TNC is involved in inflammatory processes with proinflammatory or anti-inflammatory activity in a context-dependent manner. In this review, we summarize the roles of these two tenascins, TNX and TNC, in cardiovascular and inflammatory diseases and in clEDS, and we discuss the functional consequences of the expression of these tenascins for tissue homeostasis.https://www.frontiersin.org/articles/10.3389/fimmu.2020.609752/fulltenascin-Ctenascin-Xcardiovascular diseasefibrosisinflammationEhlers-Danlos syndrome |
| spellingShingle | Ken-ichi Matsumoto Hiroki Aoki The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases Frontiers in Immunology tenascin-C tenascin-X cardiovascular disease fibrosis inflammation Ehlers-Danlos syndrome |
| title | The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases |
| title_full | The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases |
| title_fullStr | The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases |
| title_full_unstemmed | The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases |
| title_short | The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases |
| title_sort | roles of tenascins in cardiovascular inflammatory and heritable connective tissue diseases |
| topic | tenascin-C tenascin-X cardiovascular disease fibrosis inflammation Ehlers-Danlos syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.609752/full |
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