Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in mice
We studied the anticonvulsant activity of the aqueous and ethanolic extracts of Hypericum perforatum aerial parts in mice. The pentylenetetrazole (PTZ) and the maximal electroshock seizure (MES) tests were used for assessing the anticonvulsive effects of this plant. In the PTZ test, the extracts (0....
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2004-05-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-743-en.html |
| _version_ | 1819138177792737280 |
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| author | H Hosseinzadeh GR Karimi M Rakhshanizadeh |
| author_facet | H Hosseinzadeh GR Karimi M Rakhshanizadeh |
| author_sort | H Hosseinzadeh |
| collection | DOAJ |
| description | We studied the anticonvulsant activity of the aqueous and ethanolic extracts of Hypericum perforatum aerial parts in mice. The pentylenetetrazole (PTZ) and the maximal electroshock seizure (MES) tests were used for assessing the anticonvulsive effects of this plant. In the PTZ test, the extracts (0.1-1 g/kg, i.p.) delayed the onset of tonic convulsions and protected mice against mortality. In the MES test, both extracts did not show antiseizure activity. L-NAME (1-10 mg/kg, i.p.), a nitric oxide (NO) synthase inhibitor, reduced the anticonvulsant activity of the extracts. The results of this study indicate that the extracts of H. perforatum aerial parts could contribute to the control of petit mal seizure and this effect may be partially mediated by nitric oxide pathway. |
| first_indexed | 2024-12-22T11:02:38Z |
| format | Article |
| id | doaj.art-e65891c17e9d419995fbc8d98a1c254f |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-22T11:02:38Z |
| publishDate | 2004-05-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-e65891c17e9d419995fbc8d98a1c254f2022-12-21T18:28:27ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582004-05-013102330Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in miceH Hosseinzadeh0GR Karimi1M Rakhshanizadeh2 1- Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 2- Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 2- Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran We studied the anticonvulsant activity of the aqueous and ethanolic extracts of Hypericum perforatum aerial parts in mice. The pentylenetetrazole (PTZ) and the maximal electroshock seizure (MES) tests were used for assessing the anticonvulsive effects of this plant. In the PTZ test, the extracts (0.1-1 g/kg, i.p.) delayed the onset of tonic convulsions and protected mice against mortality. In the MES test, both extracts did not show antiseizure activity. L-NAME (1-10 mg/kg, i.p.), a nitric oxide (NO) synthase inhibitor, reduced the anticonvulsant activity of the extracts. The results of this study indicate that the extracts of H. perforatum aerial parts could contribute to the control of petit mal seizure and this effect may be partially mediated by nitric oxide pathway.http://jmp.ir/article-1-743-en.htmlkeywords: hypericum perforatum l.st. john's wortanticonvulsant activitypentylenetetrazolemaximal electroshock seizurenitric oxideherbal medicine |
| spellingShingle | H Hosseinzadeh GR Karimi M Rakhshanizadeh Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in mice Journal of Medicinal Plants keywords: hypericum perforatum l. st. john's wort anticonvulsant activity pentylenetetrazole maximal electroshock seizure nitric oxide herbal medicine |
| title | Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in mice |
| title_full | Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in mice |
| title_fullStr | Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in mice |
| title_full_unstemmed | Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in mice |
| title_short | Anticonvulsant effects of aqueous and ethanolic extracts of Hypericum perforatum L. in mice |
| title_sort | anticonvulsant effects of aqueous and ethanolic extracts of hypericum perforatum l in mice |
| topic | keywords: hypericum perforatum l. st. john's wort anticonvulsant activity pentylenetetrazole maximal electroshock seizure nitric oxide herbal medicine |
| url | http://jmp.ir/article-1-743-en.html |
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