High level of soluble HLA-G in the female genital tract of Beninese commercial sex workers is associated with HIV-1 infection.
Most HIV infections are transmitted across mucosal epithelium. Understanding the role of innate and specific mucosal immunity in susceptibility or protection against HIV infection, as well as the effect of HIV infection on mucosal immunity, are of fundamental importance. HLA-G is a powerful modulato...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3179477?pdf=render |
| _version_ | 1818975594411458560 |
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| author | Valérie Thibodeau Julie Lajoie Annie-Claude Labbé Marcel D Zannou Keith R Fowke Michel Alary Johanne Poudrier Michel Roger |
| author_facet | Valérie Thibodeau Julie Lajoie Annie-Claude Labbé Marcel D Zannou Keith R Fowke Michel Alary Johanne Poudrier Michel Roger |
| author_sort | Valérie Thibodeau |
| collection | DOAJ |
| description | Most HIV infections are transmitted across mucosal epithelium. Understanding the role of innate and specific mucosal immunity in susceptibility or protection against HIV infection, as well as the effect of HIV infection on mucosal immunity, are of fundamental importance. HLA-G is a powerful modulator of the immune response. The aim of this study was to investigate whether soluble HLA-G (sHLA-G) expression in the female genital tract is associated with HIV-1 infection.Genital levels of sHLA-G were determined in 52 HIV-1-uninfected and 44 antiretroviral naïve HIV-1-infected female commercial sex workers (CSWs), as well as 71 HIV-1-uninfected non-CSW women at low risk of exposure, recruited in Cotonou, Benin. HIV-1-infected CSWs had higher genital levels of sHLA-G compared with those in both the HIV-1-uninfected CSW (P = 0.009) and non-CSW groups (P = 0.0006). The presence of bacterial vaginosis (P = 0.008), and HLA-G*01:01:02 genotype (P = 0.002) were associated with higher genital levels of sHLA-G in the HIV-1-infected CSWs, whereas the HLA-G*01:04:04 genotype was also associated with higher genital level of sHLA-G in the overall population (P = 0.038). When adjustment was made for all significant variables, the increased expression of sHLA-G in the genital mucosa remained significantly associated with both HIV-1 infection (P = 0.02) and bacterial vaginosis (P = 0.03).This study demonstrates that high level of sHLA-G in the genital mucosa is independently associated with both HIV-1 infection and bacterial vaginosis. |
| first_indexed | 2024-12-20T15:58:26Z |
| format | Article |
| id | doaj.art-e65a574a9a0c4a42a9547b437628e0b0 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T15:58:26Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e65a574a9a0c4a42a9547b437628e0b02022-12-21T19:34:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2518510.1371/journal.pone.0025185High level of soluble HLA-G in the female genital tract of Beninese commercial sex workers is associated with HIV-1 infection.Valérie ThibodeauJulie LajoieAnnie-Claude LabbéMarcel D ZannouKeith R FowkeMichel AlaryJohanne PoudrierMichel RogerMost HIV infections are transmitted across mucosal epithelium. Understanding the role of innate and specific mucosal immunity in susceptibility or protection against HIV infection, as well as the effect of HIV infection on mucosal immunity, are of fundamental importance. HLA-G is a powerful modulator of the immune response. The aim of this study was to investigate whether soluble HLA-G (sHLA-G) expression in the female genital tract is associated with HIV-1 infection.Genital levels of sHLA-G were determined in 52 HIV-1-uninfected and 44 antiretroviral naïve HIV-1-infected female commercial sex workers (CSWs), as well as 71 HIV-1-uninfected non-CSW women at low risk of exposure, recruited in Cotonou, Benin. HIV-1-infected CSWs had higher genital levels of sHLA-G compared with those in both the HIV-1-uninfected CSW (P = 0.009) and non-CSW groups (P = 0.0006). The presence of bacterial vaginosis (P = 0.008), and HLA-G*01:01:02 genotype (P = 0.002) were associated with higher genital levels of sHLA-G in the HIV-1-infected CSWs, whereas the HLA-G*01:04:04 genotype was also associated with higher genital level of sHLA-G in the overall population (P = 0.038). When adjustment was made for all significant variables, the increased expression of sHLA-G in the genital mucosa remained significantly associated with both HIV-1 infection (P = 0.02) and bacterial vaginosis (P = 0.03).This study demonstrates that high level of sHLA-G in the genital mucosa is independently associated with both HIV-1 infection and bacterial vaginosis.http://europepmc.org/articles/PMC3179477?pdf=render |
| spellingShingle | Valérie Thibodeau Julie Lajoie Annie-Claude Labbé Marcel D Zannou Keith R Fowke Michel Alary Johanne Poudrier Michel Roger High level of soluble HLA-G in the female genital tract of Beninese commercial sex workers is associated with HIV-1 infection. PLoS ONE |
| title | High level of soluble HLA-G in the female genital tract of Beninese commercial sex workers is associated with HIV-1 infection. |
| title_full | High level of soluble HLA-G in the female genital tract of Beninese commercial sex workers is associated with HIV-1 infection. |
| title_fullStr | High level of soluble HLA-G in the female genital tract of Beninese commercial sex workers is associated with HIV-1 infection. |
| title_full_unstemmed | High level of soluble HLA-G in the female genital tract of Beninese commercial sex workers is associated with HIV-1 infection. |
| title_short | High level of soluble HLA-G in the female genital tract of Beninese commercial sex workers is associated with HIV-1 infection. |
| title_sort | high level of soluble hla g in the female genital tract of beninese commercial sex workers is associated with hiv 1 infection |
| url | http://europepmc.org/articles/PMC3179477?pdf=render |
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