The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats
Background & Aims: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, which has symptoms such as coughing and shortness of breath. The average survival duration in these patients is estimated as 3 years after the onset of symptoms. Today, the therapeutic approach...
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Kerman University of Medical Sciences
2015-12-01
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Series: | Journal of Kerman University of Medical Sciences |
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Online Access: | https://jkmu.kmu.ac.ir/article_16075_2140c742ca5a01b02191f4132f7bd636.pdf |
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author | Mitra Samareh-Fekri Hamid-Reza Poursalehi Ali Mandegary Fariba Sharififar Rahil Mahmoudi Atefe Izadi Mohamad-Hadi Nematolahi Nasrollah Jamshidi Fatemeh Pourgholamhossein Mohammad-Reza Lashkarizadeh |
author_facet | Mitra Samareh-Fekri Hamid-Reza Poursalehi Ali Mandegary Fariba Sharififar Rahil Mahmoudi Atefe Izadi Mohamad-Hadi Nematolahi Nasrollah Jamshidi Fatemeh Pourgholamhossein Mohammad-Reza Lashkarizadeh |
author_sort | Mitra Samareh-Fekri |
collection | DOAJ |
description | Background & Aims: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, which has symptoms such as coughing and shortness of breath. The average survival duration in these patients is estimated as 3 years after the onset of symptoms. Today, the therapeutic approach used in IPF cases is the usage of chemical or herbal antioxidants in order to eliminate free radicals and prevent inflammation and fibrosis. Considering the antioxidant properties of fennel, this research was conducted to investigate the effect of the methanol extracted of fennel on bleomycin-induced pulmonary fibrosis in rats. Methods: To induce pulmonary fibrosis in rats, intratracheal administration of 15 mg bleomycin was conducted in 52 male rates. Subsequently, the rats were injected intraperitoneally with 500 mg/(kg body weight) of methanol extract of fennel 14-day and 28-day periods. The samples were studied in terms of inflammation, fibrosis, hydroxyproline concentration, lipid peroxidation, and the catalase activity of lung tissue. The obtained results were analyzed using SPSS software. Results: The degree of inflammation, fibrosis, hydroxyproline and lipid peroxidation concentration in lung tissue in the fennel methanol extract group had significantly decreased compared to other groups. In addition, a significant increase was observed in tissue catalase concentration in this group in comparison to other groups on days 14 and 28. Conclusion: The obtained results illustrated that the methanol extract of fennel may be efficient in the prevention and treatment of pulmonary fibrosis due to its antioxidant properties. Accordingly, it can be suggested for the prevention and treatment of pulmonary fibrosis instead of corticosteroids and immunosuppressant drugs due to their many side effects and most patients’ preference of herbal medicines. |
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issn | 2008-2843 |
language | English |
last_indexed | 2024-03-13T02:08:36Z |
publishDate | 2015-12-01 |
publisher | Kerman University of Medical Sciences |
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series | Journal of Kerman University of Medical Sciences |
spelling | doaj.art-e65af0920f834e668a4a1c97e97cbc802023-07-01T05:24:45ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences2008-28432015-12-0122547048316075The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in RatsMitra Samareh-Fekri0Hamid-Reza Poursalehi1Ali Mandegary2Fariba Sharififar3Rahil Mahmoudi4Atefe Izadi5Mohamad-Hadi Nematolahi6Nasrollah Jamshidi7Fatemeh Pourgholamhossein8Mohammad-Reza Lashkarizadeh9Assistant Professor, Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IranCardiovascular Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IranGasteroenterology & Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranAssistant Professor, Department of Pharmacognosy and Herbal and Traditional Medicines Research Center, School of Pharmacy, Kerman University of Medical Sciences, Kerman, IranSchool of Pharmacy, Kerman University of Medical Sciences, Kerman, IranSchool of Pharmacy, Kerman University of Medical Sciences, Kerman, IranHerbal and Traditional Medicines Research Center, School of Pharmacy, Kerman University of Medical Sciences, Kerman, IranAfzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, IranDepartment of Pharmacology and Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, IranAssociate Professor, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, IranBackground & Aims: Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, which has symptoms such as coughing and shortness of breath. The average survival duration in these patients is estimated as 3 years after the onset of symptoms. Today, the therapeutic approach used in IPF cases is the usage of chemical or herbal antioxidants in order to eliminate free radicals and prevent inflammation and fibrosis. Considering the antioxidant properties of fennel, this research was conducted to investigate the effect of the methanol extracted of fennel on bleomycin-induced pulmonary fibrosis in rats. Methods: To induce pulmonary fibrosis in rats, intratracheal administration of 15 mg bleomycin was conducted in 52 male rates. Subsequently, the rats were injected intraperitoneally with 500 mg/(kg body weight) of methanol extract of fennel 14-day and 28-day periods. The samples were studied in terms of inflammation, fibrosis, hydroxyproline concentration, lipid peroxidation, and the catalase activity of lung tissue. The obtained results were analyzed using SPSS software. Results: The degree of inflammation, fibrosis, hydroxyproline and lipid peroxidation concentration in lung tissue in the fennel methanol extract group had significantly decreased compared to other groups. In addition, a significant increase was observed in tissue catalase concentration in this group in comparison to other groups on days 14 and 28. Conclusion: The obtained results illustrated that the methanol extract of fennel may be efficient in the prevention and treatment of pulmonary fibrosis due to its antioxidant properties. Accordingly, it can be suggested for the prevention and treatment of pulmonary fibrosis instead of corticosteroids and immunosuppressant drugs due to their many side effects and most patients’ preference of herbal medicines.https://jkmu.kmu.ac.ir/article_16075_2140c742ca5a01b02191f4132f7bd636.pdffennelpulmonary fibrosisbleomycin |
spellingShingle | Mitra Samareh-Fekri Hamid-Reza Poursalehi Ali Mandegary Fariba Sharififar Rahil Mahmoudi Atefe Izadi Mohamad-Hadi Nematolahi Nasrollah Jamshidi Fatemeh Pourgholamhossein Mohammad-Reza Lashkarizadeh The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats Journal of Kerman University of Medical Sciences fennel pulmonary fibrosis bleomycin |
title | The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats |
title_full | The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats |
title_fullStr | The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats |
title_full_unstemmed | The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats |
title_short | The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats |
title_sort | effect of methanol extract of fennel on bleomycin induced pulmonary fibrosis in rats |
topic | fennel pulmonary fibrosis bleomycin |
url | https://jkmu.kmu.ac.ir/article_16075_2140c742ca5a01b02191f4132f7bd636.pdf |
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