The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analysesResearch in context

The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analysesResearch in context

Summary: Background: Hip minimum joint space width (mJSW) provides a proxy for cartilage thickness. This study aimed to conduct a genome-wide association study (GWAS) of mJSW to (i) identify new genetic determinants of mJSW and (ii) identify which mJSW loci convey hip osteoarthritis (HOA) risk and...

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Bibliographic Details
Main Authors: Benjamin G. Faber, Monika Frysz, Cindy G. Boer, Daniel S. Evans, Raja Ebsim, Kaitlyn A. Flynn, Mischa Lundberg, Lorraine Southam, April Hartley, Fiona R. Saunders, Claudia Lindner, Jennifer S. Gregory, Richard M. Aspden, Nancy E. Lane, Nicholas C. Harvey, David M. Evans, Eleftheria Zeggini, George Davey Smith, Timothy Cootes, Joyce Van Meurs, John P. Kemp, Jonathan H. Tobias
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:EBioMedicine
Subjects:
Osteoarthritis
Genome-wide association study
Mendelian randomisation
Cartilage
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423003249

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