Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests.
The purpose of the study was to evaluate the diagnostic accuracy of visual function tests in intermediate age-related macular degeneration (iAMD). A total of 62 subjects (38 patients with iAMD and 24 controls) were included and underwent several functional assessments: Best-corrected visual acuity (...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0231748 |
| _version_ | 1818677809289101312 |
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| author | Susanne G Pondorfer Manuel Heinemann Maximilian W M Wintergerst Maximilian Pfau Annika L Strömer Frank G Holz Robert P Finger |
| author_facet | Susanne G Pondorfer Manuel Heinemann Maximilian W M Wintergerst Maximilian Pfau Annika L Strömer Frank G Holz Robert P Finger |
| author_sort | Susanne G Pondorfer |
| collection | DOAJ |
| description | The purpose of the study was to evaluate the diagnostic accuracy of visual function tests in intermediate age-related macular degeneration (iAMD). A total of 62 subjects (38 patients with iAMD and 24 controls) were included and underwent several functional assessments: Best-corrected visual acuity (BCVA), low luminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Vanishing Optotypes Acuity Charts (MAC), contrast sensitivity with the Pelli-Robson test, reading speed using the International Reading Speed texts (IReST) and mesopic and dark-adapted microperimetry (S-MAIA, CenterVue, Padova, Italy). Groups were compared using non-parametric Wilcoxon rank sum tests and ROC analyses. Linear regression was used to control for confounding. Results showed that all visual function test performances except the IReST were significantly reduced in iAMD patients compared to controls (p < 0.05). These effects did not alter after controlling for age and sex. Best discrimination between iAMD and controls yield the combination of LLVA and contrast sensitivity as well as MAC-VA and contrast sensitivity (ROC area under the curve 0.95 and 0.93, respectively). Our results suggest that LLVA, MAC-VA, contrast sensitivity and mesopic and dark-adapted microperimetry can capture visual impairment characteristic for iAMD. Best discrimination against iAMD is achieved with a combination of two tests. |
| first_indexed | 2024-12-17T09:05:16Z |
| format | Article |
| id | doaj.art-e65ba7efe7e24418a55a81ece130737d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T09:05:16Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e65ba7efe7e24418a55a81ece130737d2022-12-21T21:55:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01154e023174810.1371/journal.pone.0231748Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests.Susanne G PondorferManuel HeinemannMaximilian W M WintergerstMaximilian PfauAnnika L StrömerFrank G HolzRobert P FingerThe purpose of the study was to evaluate the diagnostic accuracy of visual function tests in intermediate age-related macular degeneration (iAMD). A total of 62 subjects (38 patients with iAMD and 24 controls) were included and underwent several functional assessments: Best-corrected visual acuity (BCVA), low luminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Vanishing Optotypes Acuity Charts (MAC), contrast sensitivity with the Pelli-Robson test, reading speed using the International Reading Speed texts (IReST) and mesopic and dark-adapted microperimetry (S-MAIA, CenterVue, Padova, Italy). Groups were compared using non-parametric Wilcoxon rank sum tests and ROC analyses. Linear regression was used to control for confounding. Results showed that all visual function test performances except the IReST were significantly reduced in iAMD patients compared to controls (p < 0.05). These effects did not alter after controlling for age and sex. Best discrimination between iAMD and controls yield the combination of LLVA and contrast sensitivity as well as MAC-VA and contrast sensitivity (ROC area under the curve 0.95 and 0.93, respectively). Our results suggest that LLVA, MAC-VA, contrast sensitivity and mesopic and dark-adapted microperimetry can capture visual impairment characteristic for iAMD. Best discrimination against iAMD is achieved with a combination of two tests.https://doi.org/10.1371/journal.pone.0231748 |
| spellingShingle | Susanne G Pondorfer Manuel Heinemann Maximilian W M Wintergerst Maximilian Pfau Annika L Strömer Frank G Holz Robert P Finger Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests. PLoS ONE |
| title | Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests. |
| title_full | Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests. |
| title_fullStr | Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests. |
| title_full_unstemmed | Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests. |
| title_short | Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests. |
| title_sort | detecting vision loss in intermediate age related macular degeneration a comparison of visual function tests |
| url | https://doi.org/10.1371/journal.pone.0231748 |
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