Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels
Abstract Background Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothe...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Komiyama Printing Co. Ltd
2018-05-01
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| Series: | Environmental Health and Preventive Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12199-018-0705-4 |
| _version_ | 1818501908186267648 |
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| author | Yuji Shimizu Shimpei Sato Jun Koyamatsu Hirotomo Yamanashi Mako Nagayoshi Shin-Ya Kawashiri Keita Inoue Shoichi Fukui Hideaki Kondo Seiko Nakamichi Yasuhiro Nagata Takahiro Maeda |
| author_facet | Yuji Shimizu Shimpei Sato Jun Koyamatsu Hirotomo Yamanashi Mako Nagayoshi Shin-Ya Kawashiri Keita Inoue Shoichi Fukui Hideaki Kondo Seiko Nakamichi Yasuhiro Nagata Takahiro Maeda |
| author_sort | Yuji Shimizu |
| collection | DOAJ |
| description | Abstract Background Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT. Methods We conducted a cross-sectional study of 269 elderly Japanese men aged 60–69 years who had undertaken an annual medical checkup from 2014 to 2015. Results The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (≤ 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels. Conclusion A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men. |
| first_indexed | 2024-12-10T21:02:44Z |
| format | Article |
| id | doaj.art-e65bc47c509e4926b6008cd0effb85ae |
| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-12-10T21:02:44Z |
| publishDate | 2018-05-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-e65bc47c509e4926b6008cd0effb85ae2022-12-22T01:33:45ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152018-05-012311810.1186/s12199-018-0705-4Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levelsYuji Shimizu0Shimpei Sato1Jun Koyamatsu2Hirotomo Yamanashi3Mako Nagayoshi4Shin-Ya Kawashiri5Keita Inoue6Shoichi Fukui7Hideaki Kondo8Seiko Nakamichi9Yasuhiro Nagata10Takahiro Maeda11Department of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Island and Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Island and Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesDepartment of General Medicine, Nagasaki University HospitalCenter for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical SciencesDepartment of Community Medicine, Nagasaki University Graduate School of Biomedical SciencesAbstract Background Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT. Methods We conducted a cross-sectional study of 269 elderly Japanese men aged 60–69 years who had undertaken an annual medical checkup from 2014 to 2015. Results The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (≤ 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels. Conclusion A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men.http://link.springer.com/article/10.1186/s12199-018-0705-4CD34-positive cellCIMTEndothelial repairHGFElderly men |
| spellingShingle | Yuji Shimizu Shimpei Sato Jun Koyamatsu Hirotomo Yamanashi Mako Nagayoshi Shin-Ya Kawashiri Keita Inoue Shoichi Fukui Hideaki Kondo Seiko Nakamichi Yasuhiro Nagata Takahiro Maeda Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels Environmental Health and Preventive Medicine CD34-positive cell CIMT Endothelial repair HGF Elderly men |
| title | Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels |
| title_full | Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels |
| title_fullStr | Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels |
| title_full_unstemmed | Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels |
| title_short | Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels |
| title_sort | hepatocyte growth factor and carotid intima media thickness in relation to circulating cd34 positive cell levels |
| topic | CD34-positive cell CIMT Endothelial repair HGF Elderly men |
| url | http://link.springer.com/article/10.1186/s12199-018-0705-4 |
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