Strategies for measuring airway mucus and mucins
Abstract Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such, mucus abnormalities are hallmark features of many respiratory diseases, including...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Respiratory Research |
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| Online Access: | http://link.springer.com/article/10.1186/s12931-019-1239-z |
| _version_ | 1818198199565811712 |
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| author | Kalina R. Atanasova Leah R. Reznikov |
| author_facet | Kalina R. Atanasova Leah R. Reznikov |
| author_sort | Kalina R. Atanasova |
| collection | DOAJ |
| description | Abstract Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such, mucus abnormalities are hallmark features of many respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD). Studying mucus composition and its physical properties has therefore been of significant interest both clinically and scientifically. Yet, measuring mucus production, output, composition and transport presents several challenges. Here we summarize and discuss the advantages and limitations of several techniques from five broadly characterized strategies used to measure mucus secretion, composition and mucociliary transport, with an emphasis on the gel-forming mucins. Further, we summarize advances in the field, as well as suggest potential areas of improvement moving forward. |
| first_indexed | 2024-12-12T02:02:05Z |
| format | Article |
| id | doaj.art-e65dcd6a44004b33b78740422d9233fa |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-12-12T02:02:05Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-e65dcd6a44004b33b78740422d9233fa2022-12-22T00:42:09ZengBMCRespiratory Research1465-993X2019-11-0120111410.1186/s12931-019-1239-zStrategies for measuring airway mucus and mucinsKalina R. Atanasova0Leah R. Reznikov1Department of Physiological Sciences, University of FloridaDepartment of Physiological Sciences, University of FloridaAbstract Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such, mucus abnormalities are hallmark features of many respiratory diseases, including asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD). Studying mucus composition and its physical properties has therefore been of significant interest both clinically and scientifically. Yet, measuring mucus production, output, composition and transport presents several challenges. Here we summarize and discuss the advantages and limitations of several techniques from five broadly characterized strategies used to measure mucus secretion, composition and mucociliary transport, with an emphasis on the gel-forming mucins. Further, we summarize advances in the field, as well as suggest potential areas of improvement moving forward.http://link.springer.com/article/10.1186/s12931-019-1239-zAirway mucusMucociliary transportTechniquesMucins |
| spellingShingle | Kalina R. Atanasova Leah R. Reznikov Strategies for measuring airway mucus and mucins Respiratory Research Airway mucus Mucociliary transport Techniques Mucins |
| title | Strategies for measuring airway mucus and mucins |
| title_full | Strategies for measuring airway mucus and mucins |
| title_fullStr | Strategies for measuring airway mucus and mucins |
| title_full_unstemmed | Strategies for measuring airway mucus and mucins |
| title_short | Strategies for measuring airway mucus and mucins |
| title_sort | strategies for measuring airway mucus and mucins |
| topic | Airway mucus Mucociliary transport Techniques Mucins |
| url | http://link.springer.com/article/10.1186/s12931-019-1239-z |
| work_keys_str_mv | AT kalinaratanasova strategiesformeasuringairwaymucusandmucins AT leahrreznikov strategiesformeasuringairwaymucusandmucins |