Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids

Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids

Combining two pharmacophores in a molecule can lead to useful synergistic effects. Herein, we show hybrid systems that combine sterically hindered phenols with dinitrobenzofuroxan fragments exhibit a broad range of biological activities. The modular assembly of such phenol/benzofuroxan hybrids allow...

Full description

Bibliographic Details
Main Authors:	Elena Chugunova, Elmira Gibadullina, Kirill Matylitsky, Baurat Bazarbayev, Margarita Neganova, Konstantin Volcho, Artem Rogachev, Nurgali Akylbekov, Hoang Bao Tran Nguyen, Alexandra Voloshina, Anna Lyubina, Syumbelya Amerhanova, Victor Syakaev, Alexander Burilov, Nurbol Appazov, Mukhtar Zhanakov, Leah Kuhn, Oleg Sinyashin, Igor Alabugin
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	Pharmaceuticals
Subjects:	benzofuroxan sterically hindered phenol anti-cancer activity cytotoxicity apoptosis ROS production
Online Access:	https://www.mdpi.com/1424-8247/16/4/499

Similar Items

Kinetic Study of the Reaction of Benzofuroxans with 2-Acetylthiophene: Effect of the Substituents on the Reaction Rate Using Hammett Equation
by: Intisar Salih Ahmed, et al.
Published: (2020-05-01)

Kinetic Study of the Reaction of Benzofuroxans with 2-Acetylthiophene: Effect of the Substituents on the Reaction Rate Using Hammett Equation
by: Damra Elhaj Mustafa, et al.
Published: (2020-05-01)

Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
by: Débora Leite Campos, et al.
Published: (2024-10-01)

SYNTHESIS AND ACARICIDAL, BACTERIOSTATIC ACTIVITY AMONG THE AMINO DERIVATIVES 5,7-DICHLORO-4,6-DINITROBENZOFUROXANA
by: L. V. Spatlova, et al.
Published: (2019-01-01)

Synthesis, Acaricidal, Bacteriostatic Activity Among the Amino Derivatives 5,7-Dichloro-4,6-Dinitrobenzofuroxana
by: L. V. Spatlova
Published: (2019-05-01)

An Unusual Rearrangement of Pyrazole Nitrene and Coarctate Ring-Opening/Recyclization Cascade: Formal CH–Acetoxylation and Azide/Amine Conversion without External Oxidants and Reductants
by: Elena Chugunova, et al.
Published: (2023-10-01)

Information Security Management in Small Public Sector Organizations: Requirements and Design of a Procedural Approach
by: Frank Moses, et al.
Published: (2023-12-01)

Synthesis, Redox Properties and Antibacterial Activity of Hindered Phenols Linked to Heterocycles
by: Vladimir N. Koshelev, et al.
Published: (2020-05-01)

How to successfully publish interdisciplinary research: learning from an Ecology and Society Special Feature
by: Christian Pohl, et al.
Published: (2015-06-01)

The Highly Regioselective Synthesis of Novel Imidazolidin-2-Ones via the Intramolecular Cyclization/Electrophilic Substitution of Urea Derivatives and the Evaluation of Their Anticancer Activity
by: Almir S. Gazizov, et al.
Published: (2021-07-01)

The impact of policy timing on the spread of COVID-19
by: Moshe Elitzur, et al.
Published: (2021-01-01)

Can Hindered Transport Models for Rigid Spheres Predict the Rejection of Single Stranded DNA from Porous Membranes?
by: Hossein Nouri Alavijeh, et al.
Published: (2022-11-01)

Synthesis and photostabilizing performance of a polymeric HALS based on 1,2,2,6,6-pentamethylpiperidine and vinyl acetate
by: Marcelo Aparecido Chinelatto, et al.
Published: (2015-01-01)

Blood, lead and spheres: A hindered settling equation for sedimentologists based on metadata analysis
by: Jaco H. Baas, et al.
Published: (2022-06-01)

The case for social evaluation in preverbal infants: Gazing toward one’s goal drives infants’ preferences for Helpers over Hinderers in the hill paradigm
by: J Kiley eHamlin
Published: (2015-01-01)

Extending mechanochemical porphyrin synthesis to bulkier aromatics: tetramesitylporphyrin
by: Qiwen Su, et al.
Published: (2019-05-01)

Supramolecular Self-Assembly of Porphyrin and Metallosurfactant as a Drug Nanocontainer Design
by: Ruslan R. Kashapov, et al.
Published: (2022-06-01)

Comparative Assessment of the Phytochemical Composition and Biological Activity of Extracts of Flowering Plants of <i>Centaurea cyanus</i> L., <i>Centaurea jacea</i> L. and <i>Centaurea scabiosa</i> L.
by: Natalia Sharonova, et al.
Published: (2021-06-01)

Carboxybetaine and Carboxybetaine Ester Derivatives of Tetra(dodecyloxyphenyl)-calix[4]resorcinarene: Synthesis, Self-Assembly and In Vitro Toxicity
by: Julia E. Morozova, et al.
Published: (2023-01-01)

From Zero Collaboration to Teamwork: Forms of Teacher Collaboration and Factors That Support or Hinder It
by: Katrin Saks, et al.
Published: (2025-01-01)

Contributing and Hindering Factors of Learner’s Persistence in a Free Basic Education
by: Kim Hyoduk, et al.
Published: (2024-04-01)

Quand l’organisation empêche un travail de qualité : étude de cas
by: Johann Petit, et al.
Published: (2012-08-01)

Preventive seizure of hindering nature also for legal entities pursuant to Legislative Decree 231/2001: a constitutionally oriented interpretation with the “taste” of an addition
by: Roberto Losengo
Published: (2018-11-01)

Curriculum Implementation Facilitating and Hindering Factors: The Philippines Context
by: Randy L Palestina, et al.
Published: (2020-12-01)

The Hindered Settling Velocity of Particles of Any Shape in Low Reynolds Number Flow
by: Yuri Mendez
Published: (2023-01-01)

Return to Work after an Acute Coronary Syndrome: Patients’ Perspective
by: Frans G. Slebus, et al.
Published: (2012-06-01)

UV aging behavior evolution characterization of HALS-modified asphalt based on micro-morphological features
by: Sun Xiaolong, et al.
Published: (2023-09-01)

Synthesis and characterization of copolymers from hindered amines and vinyl monomers
by: Marcelo Aparecido Chinelatto, et al.
Published: (2014-01-01)

Original article Personality of correction officers and their attitudes towards resocialization tasks
by: Maria Gordon
Published: (2014-07-01)

Do Dogs Prefer Helpers in an Infant-Based Social Evaluation Task?
by: Katherine McAuliffe, et al.
Published: (2019-03-01)

Interest in research among female medical students at Al-Azhar University in Cairo, Egypt
by: Hanaa A.E.A Elhassan, et al.
Published: (2021-01-01)

Synthesis and diverse biological activity profile of triethylammonium isatin-3-hydrazones
by: Andrei Bogdanov, et al.
Published: (2022-01-01)

Synthesis, Characterization, and Evaluation of a Hindered Phenol-Linked Benzophenone Hybrid Compound as a Potential Polymer Anti-Aging Agent
by: Shenshuai Wang, et al.
Published: (2024-07-01)

Study on the influence of suspension layer on treatment effect of vertical flow sedimentation
by: YAN Bipeng, et al.
Published: (2024-08-01)

CO<sub>2</sub> Absorption Mechanism by the Nonaqueous Solvent Consisting of Hindered Amine 2-[(1,1-dimethylethyl)amino]ethanol and Ethylene Glycol
by: Ran Li, et al.
Published: (2020-12-01)

Investigating the Key Hindering Factors and Mechanism of BIM Applications Based on Social Network Analysis
by: Zezhou Wu, et al.
Published: (2022-08-01)

Analysis of Promoting and Hindering Factors for Implementation of Medical Tourism Policies: Case Study in Golestan Province
by: Hossein Livani, et al.
Published: (2023-03-01)

Preparation of high vinyl polybutadiene rubber via coordination polymerization with low-steric-hindrance alkoxy multi-substituted molybdenum
by: XIE Ting-hao; TANG Jian; GENG Jie-ting; WANG Xiao-tong; HUA Jing
Published: (2022-05-01)

Modeling the parameters for plasmodesmal sugar filtering in active symplasmic phloem loaders
by: Johannes eLiesche, et al.
Published: (2013-06-01)

Innovation Activity of Slovak SMEs Operating in the ICT Sector
Published: (2025-01-01)