Post-COVID Condition in Adults and Children Living in the Same Household in Italy: A Prospective Cohort Study Using the ISARIC Global Follow-Up Protocol
BackgroundEmerging evidence shows that both adults and children may develop post-acute sequelae of SARS-CoV-2 infection (PASC). The aim of this study is to characterise and compare long-term post-SARS-CoV-2 infection outcomes in adults and children in a defined region in Italy.MethodsA prospective c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.834875/full |
| _version_ | 1818061334076456960 |
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| author | Danilo Buonsenso Danilo Buonsenso Danilo Buonsenso Daniel Munblit Daniel Munblit Ekaterina Pazukhina Ekaterina Pazukhina Antonia Ricchiuto Dario Sinatti Margherita Zona Alessia De Matteis Federico D’Ilario Carolina Gentili Roberta Lanni Teresa Rongai Patrizia del Balzo Maria Teresa Fonte Michele Valente Giuseppe Zampino Cristina De Rose Louise Sigfrid Piero Valentini Piero Valentini FIMP-Roma Ilaria Sani Giovanna La Cava Serenella Castronuovo Isabella Capodici Ermenia Zirletta Loredana Costabile Di Martino Lorenza Arnaboldi Maria Concetta Carbone Rosella Sebastianelli Cristina Ciuffo Donatella Marano Cinzia Grassi Immacolata La Bella Luciano Sozio |
| author_facet | Danilo Buonsenso Danilo Buonsenso Danilo Buonsenso Daniel Munblit Daniel Munblit Ekaterina Pazukhina Ekaterina Pazukhina Antonia Ricchiuto Dario Sinatti Margherita Zona Alessia De Matteis Federico D’Ilario Carolina Gentili Roberta Lanni Teresa Rongai Patrizia del Balzo Maria Teresa Fonte Michele Valente Giuseppe Zampino Cristina De Rose Louise Sigfrid Piero Valentini Piero Valentini FIMP-Roma Ilaria Sani Giovanna La Cava Serenella Castronuovo Isabella Capodici Ermenia Zirletta Loredana Costabile Di Martino Lorenza Arnaboldi Maria Concetta Carbone Rosella Sebastianelli Cristina Ciuffo Donatella Marano Cinzia Grassi Immacolata La Bella Luciano Sozio |
| author_sort | Danilo Buonsenso |
| collection | DOAJ |
| description | BackgroundEmerging evidence shows that both adults and children may develop post-acute sequelae of SARS-CoV-2 infection (PASC). The aim of this study is to characterise and compare long-term post-SARS-CoV-2 infection outcomes in adults and children in a defined region in Italy.MethodsA prospective cohort study including children (≤18 years old) with PCR-confirmed SARS-CoV-2 infection and their household members. Participants were assessed via telephone and face-to-face visits up to 12 months post-SARS-CoV-2 diagnosis of household index case, using the ISARIC COVID-19 follow-up survey.ResultsOf 507 participants from 201 households, 56.4% (286/507) were children, 43.6% (221/507) adults. SARS-CoV-2 positivity was 87% (249/286) in children, and 78% (172/221) in adults. The mean age of PCR positive children was 10.4 (SD = 4.5) and of PCR positive adults was 44.5 years (SD = 9.5), similar to the PCR negative control groups [children 10.5 years (SD = 3.24), adults 42.3 years (SD = 9.06)]. Median follow-up post-SARS-CoV-2 diagnosis was 77 days (IQR 47–169). A significantly higher proportion of adults compared to children reported at least one persistent symptom (67%, 68/101 vs. 32%, 57/179, p < 0.001) at the first follow up. Adults had more frequently coexistence of several symptom categories at both follow-up time-points. Female gender was identified as a risk factor for PASC in adults (p 0.02 at 1–3 months and p 0.01 at 6–9 months follow up), but not in children. We found no significant correlation between adults and children symptoms. In the paediatric group, there was a significant difference in persisting symptoms between those with confirmed SARS-CoV-2 infection compared to controls at 1–3 months follow up, but not at 6–9 months. Conversely, positive adults had a higher frequency of persisting symptoms at both follow-up assessments.ConclusionOur data highlights that children can experience persistent multisystemic symptoms months after diagnosis of mild acute SARS-CoV-2 infection, although less frequently and less severely than co-habitant adults. There was no correlation between symptoms experienced by adults and children living in the same household. Our data highlights an urgent need for studies to characterise PASC in whole populations and the wider impact on families. |
| first_indexed | 2024-12-10T13:46:39Z |
| format | Article |
| id | doaj.art-e65f9ca76df8412fb0ca744ac4fe3ba0 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-10T13:46:39Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-e65f9ca76df8412fb0ca744ac4fe3ba02022-12-22T01:46:26ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-04-011010.3389/fped.2022.834875834875Post-COVID Condition in Adults and Children Living in the Same Household in Italy: A Prospective Cohort Study Using the ISARIC Global Follow-Up ProtocolDanilo Buonsenso0Danilo Buonsenso1Danilo Buonsenso2Daniel Munblit3Daniel Munblit4Ekaterina Pazukhina5Ekaterina Pazukhina6Antonia Ricchiuto7Dario Sinatti8Margherita Zona9Alessia De Matteis10Federico D’Ilario11Carolina Gentili12Roberta Lanni13Teresa Rongai14Patrizia del Balzo15Maria Teresa Fonte16Michele Valente17Giuseppe Zampino18Cristina De Rose19Louise Sigfrid20Piero Valentini21Piero Valentini22FIMP-RomaIlaria SaniGiovanna La CavaSerenella CastronuovoIsabella CapodiciErmenia ZirlettaLoredana CostabileDi MartinoLorenza ArnaboldiMaria Concetta CarboneRosella SebastianelliCristina CiuffoDonatella MaranoCinzia GrassiImmacolata La BellaLuciano SozioDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyGlobal Health Research Institute, Istituto di Igiene, Università Cattolica del Sacro Cuore, Rome, ItalySezione di Microbiologia, Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, Rome, ItalyDepartment of Paediatrics and Paediatric Infectious Diseases, Institute of Child’s Health, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, RussiaInflammation, Repair and Development Section, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London, United KingdomLaboratory of Health Economics, Institute of Applied Economic Studies, Russian Presidential Academy of National Economy and Public Administration, Moscow, RussiaCenter for Advanced Financial Planning, Macroeconomic Analysis and Financial Statistics, Financial Research Institute, Ministry of Finance of the Russian Federation, Moscow, RussiaDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyPediatra di Libera Scelta, Federazione Italiana Medici Pediatri, Rome, ItalyPediatra di Libera Scelta, Federazione Italiana Medici Pediatri, Rome, ItalyPediatra di Libera Scelta, Federazione Italiana Medici Pediatri, Rome, ItalyPediatra di Libera Scelta, Federazione Italiana Medici Pediatri, Rome, ItalyPediatra di Libera Scelta, Federazione Italiana Medici Pediatri, Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyInternational Severe Acute Respiratory and Emerging Infection Consortium Global Support Centre, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United KingdomDepartment of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyGlobal Health Research Institute, Istituto di Igiene, Università Cattolica del Sacro Cuore, Rome, ItalyBackgroundEmerging evidence shows that both adults and children may develop post-acute sequelae of SARS-CoV-2 infection (PASC). The aim of this study is to characterise and compare long-term post-SARS-CoV-2 infection outcomes in adults and children in a defined region in Italy.MethodsA prospective cohort study including children (≤18 years old) with PCR-confirmed SARS-CoV-2 infection and their household members. Participants were assessed via telephone and face-to-face visits up to 12 months post-SARS-CoV-2 diagnosis of household index case, using the ISARIC COVID-19 follow-up survey.ResultsOf 507 participants from 201 households, 56.4% (286/507) were children, 43.6% (221/507) adults. SARS-CoV-2 positivity was 87% (249/286) in children, and 78% (172/221) in adults. The mean age of PCR positive children was 10.4 (SD = 4.5) and of PCR positive adults was 44.5 years (SD = 9.5), similar to the PCR negative control groups [children 10.5 years (SD = 3.24), adults 42.3 years (SD = 9.06)]. Median follow-up post-SARS-CoV-2 diagnosis was 77 days (IQR 47–169). A significantly higher proportion of adults compared to children reported at least one persistent symptom (67%, 68/101 vs. 32%, 57/179, p < 0.001) at the first follow up. Adults had more frequently coexistence of several symptom categories at both follow-up time-points. Female gender was identified as a risk factor for PASC in adults (p 0.02 at 1–3 months and p 0.01 at 6–9 months follow up), but not in children. We found no significant correlation between adults and children symptoms. In the paediatric group, there was a significant difference in persisting symptoms between those with confirmed SARS-CoV-2 infection compared to controls at 1–3 months follow up, but not at 6–9 months. Conversely, positive adults had a higher frequency of persisting symptoms at both follow-up assessments.ConclusionOur data highlights that children can experience persistent multisystemic symptoms months after diagnosis of mild acute SARS-CoV-2 infection, although less frequently and less severely than co-habitant adults. There was no correlation between symptoms experienced by adults and children living in the same household. Our data highlights an urgent need for studies to characterise PASC in whole populations and the wider impact on families.https://www.frontiersin.org/articles/10.3389/fped.2022.834875/fullCOVID-19long COVIDpost-COVID “long-haulers”childrenadults |
| spellingShingle | Danilo Buonsenso Danilo Buonsenso Danilo Buonsenso Daniel Munblit Daniel Munblit Ekaterina Pazukhina Ekaterina Pazukhina Antonia Ricchiuto Dario Sinatti Margherita Zona Alessia De Matteis Federico D’Ilario Carolina Gentili Roberta Lanni Teresa Rongai Patrizia del Balzo Maria Teresa Fonte Michele Valente Giuseppe Zampino Cristina De Rose Louise Sigfrid Piero Valentini Piero Valentini FIMP-Roma Ilaria Sani Giovanna La Cava Serenella Castronuovo Isabella Capodici Ermenia Zirletta Loredana Costabile Di Martino Lorenza Arnaboldi Maria Concetta Carbone Rosella Sebastianelli Cristina Ciuffo Donatella Marano Cinzia Grassi Immacolata La Bella Luciano Sozio Post-COVID Condition in Adults and Children Living in the Same Household in Italy: A Prospective Cohort Study Using the ISARIC Global Follow-Up Protocol Frontiers in Pediatrics COVID-19 long COVID post-COVID “long-haulers” children adults |
| title | Post-COVID Condition in Adults and Children Living in the Same Household in Italy: A Prospective Cohort Study Using the ISARIC Global Follow-Up Protocol |
| title_full | Post-COVID Condition in Adults and Children Living in the Same Household in Italy: A Prospective Cohort Study Using the ISARIC Global Follow-Up Protocol |
| title_fullStr | Post-COVID Condition in Adults and Children Living in the Same Household in Italy: A Prospective Cohort Study Using the ISARIC Global Follow-Up Protocol |
| title_full_unstemmed | Post-COVID Condition in Adults and Children Living in the Same Household in Italy: A Prospective Cohort Study Using the ISARIC Global Follow-Up Protocol |
| title_short | Post-COVID Condition in Adults and Children Living in the Same Household in Italy: A Prospective Cohort Study Using the ISARIC Global Follow-Up Protocol |
| title_sort | post covid condition in adults and children living in the same household in italy a prospective cohort study using the isaric global follow up protocol |
| topic | COVID-19 long COVID post-COVID “long-haulers” children adults |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.834875/full |
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