Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats
L-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplemen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal de Santa Catarina
2012-04-01
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| Series: | Revista Brasileira de Cineantropometria e Desempenho Humano |
| Subjects: | |
| Online Access: | https://periodicos.ufsc.br/index.php/rbcdh/article/view/19207 |
| _version_ | 1828467700681146368 |
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| author | Rossana Anelice Gomez Miguel de Arruda Fabio Pinhero Ramos Marco Antonio Cossio Bolaños |
| author_facet | Rossana Anelice Gomez Miguel de Arruda Fabio Pinhero Ramos Marco Antonio Cossio Bolaños |
| author_sort | Rossana Anelice Gomez |
| collection | DOAJ |
| description | L-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplementation on muscle fatigue in sciatic nerve-gastrocnemius muscle preparations in sedentary and trained rats. The animals were divided into 4 groups: non-supplemented sedentary (NSS), supplemented sedentary (SS), non-supplemented trained (NST), and supplemented trained (ST) rats. The animals were trained in daily 1-h sessions (5 days/week) and received chronic oral L-carnitine supplementation (1 mg/mL) for 4 weeks. Muscle fatigue was determined by supramaximal tetanic stimulation of the sciatic nerve (50 Hz). Time values for strength reduction were significantly different (p<0.05) between NSS vs. SS and NST vs. ST rats. No significant differences were observed between SS vs. ST and NST vs. NSS rats. These findings demonstrate that L-carnitine lengthen the time required for induction of muscle fatigue. |
| first_indexed | 2024-12-11T04:11:34Z |
| format | Article |
| id | doaj.art-e65fd81d08e544fdbfa9d3f04ba22e71 |
| institution | Directory Open Access Journal |
| issn | 1415-8426 1980-0037 |
| language | English |
| last_indexed | 2024-12-11T04:11:34Z |
| publishDate | 2012-04-01 |
| publisher | Universidade Federal de Santa Catarina |
| record_format | Article |
| series | Revista Brasileira de Cineantropometria e Desempenho Humano |
| spelling | doaj.art-e65fd81d08e544fdbfa9d3f04ba22e712022-12-22T01:21:22ZengUniversidade Federal de Santa CatarinaRevista Brasileira de Cineantropometria e Desempenho Humano1415-84261980-00372012-04-0114332433210.5007/1980-0037.2012v14n3p32417873Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary ratsRossana Anelice Gomez0Miguel de Arruda1Fabio Pinhero Ramos2Marco Antonio Cossio Bolaños3Universidad Estadual de Campinas. Facultad de Educacion Fisica. Campinas, SP. BrazilUniversidad Estadual de Campinas. Facultad de Educacion Fisica. Campinas, SP. BrazilUUniversidad Tras-os-Montes e Alto Douro. Facultad de Educacion Fisica. Vila Real. PortugalUniversidad Estadual de Campinas. Facultad de Educacion Fisica. Campinas, SP. BrazilL-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplementation on muscle fatigue in sciatic nerve-gastrocnemius muscle preparations in sedentary and trained rats. The animals were divided into 4 groups: non-supplemented sedentary (NSS), supplemented sedentary (SS), non-supplemented trained (NST), and supplemented trained (ST) rats. The animals were trained in daily 1-h sessions (5 days/week) and received chronic oral L-carnitine supplementation (1 mg/mL) for 4 weeks. Muscle fatigue was determined by supramaximal tetanic stimulation of the sciatic nerve (50 Hz). Time values for strength reduction were significantly different (p<0.05) between NSS vs. SS and NST vs. ST rats. No significant differences were observed between SS vs. ST and NST vs. NSS rats. These findings demonstrate that L-carnitine lengthen the time required for induction of muscle fatigue.https://periodicos.ufsc.br/index.php/rbcdh/article/view/19207muscle fatiguesupplementationtraining. |
| spellingShingle | Rossana Anelice Gomez Miguel de Arruda Fabio Pinhero Ramos Marco Antonio Cossio Bolaños Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats Revista Brasileira de Cineantropometria e Desempenho Humano muscle fatigue supplementation training. |
| title | Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
| title_full | Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
| title_fullStr | Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
| title_full_unstemmed | Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
| title_short | Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
| title_sort | effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats |
| topic | muscle fatigue supplementation training. |
| url | https://periodicos.ufsc.br/index.php/rbcdh/article/view/19207 |
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