Dynamic changes in marital status and survival in women with breast cancer: a population-based study
Abstract Marital status proved to be an independent prognostic factor for survival in patients with breast cancer. We therefore strove to explore the impact of dynamic changes in marital status on the prognosis of breast cancer patients. We selected patients meeting the eligibility criteria from the...
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| Format: | Article |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84996-y |
| _version_ | 1818421431797547008 |
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| author | Wu Ding Guodong Ruan Yingli Lin Jianming Zhu Chuanjian Tu Zhian Li |
| author_facet | Wu Ding Guodong Ruan Yingli Lin Jianming Zhu Chuanjian Tu Zhian Li |
| author_sort | Wu Ding |
| collection | DOAJ |
| description | Abstract Marital status proved to be an independent prognostic factor for survival in patients with breast cancer. We therefore strove to explore the impact of dynamic changes in marital status on the prognosis of breast cancer patients. We selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, and End Results cancer database. We then used multivariate Cox proportional hazard regression model to analyze the effect of dynamic changes in marital status on the prognosis of overall survival (OS) and breast cancer-specific special survival (BCSS). Compared with the patients in the Single–Single group and the divorced/separated/widowed–divorced/separated/widowed (DSW–DSW) group, patients in the Married–Married group were significantly associated with better BCSS (HR 1.13, 95% CI: 1.03–1.19, P < 0.001; HR 1.19, 95% CI: 1.14–1.25, P < 0.001, respectively) and OS (HR 1.25, 95% CI: 1.20–1.30, P < 0.001; HR 1.49, 95% CI: 1.45–1.54, P < 0.001, respectively). In contrast to the DSW–DSW group, the Single–Single group and the DSW–Married group showed similar BCSS (HR 0.98, 95% CI: 0.92–1.05, P = 0.660; HR 1.06, 95% CI: 0.97–1.15, P = 0.193, respectively) but better OS (HR 1.14, 95% CI: 1.09–1.19, P < 0.001; HR 1.32, 95% CI: 1.25–1.40, P < 0.001, respectively). Compared with the Single–Single group, the Single–Married group showed significantly better BCSS (HR 1.21, 95% CI: 1.07–1.36, P = 0.003) but no difference in OS (HR 1.08, 95% CI: 0.98–1.18, P = 0.102); In contrast to the Married–DSW group, the Married–Married group exhibited better BCSS (HR 1.11, 95% CI: 1.05–1.18, P < 0.001) and OS (HR 1.27, 95% CI: 1.22–1.32, P < 0.001). Our study demonstrated that, regardless of their previous marital status, married patients had a better prognosis than unmarried patients. Moreover, single patients obtained better survival outcomes than DSW patients. Therefore, it is necessary to proactively provide single and DSW individuals with appropriate social and psychological support that would benefit them. |
| first_indexed | 2024-12-14T13:10:15Z |
| format | Article |
| id | doaj.art-e6606b9de05e4f08924b85c04559bf45 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T13:10:15Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
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| spelling | doaj.art-e6606b9de05e4f08924b85c04559bf452022-12-21T23:00:13ZengNature PortfolioScientific Reports2045-23222021-03-011111810.1038/s41598-021-84996-yDynamic changes in marital status and survival in women with breast cancer: a population-based studyWu Ding0Guodong Ruan1Yingli Lin2Jianming Zhu3Chuanjian Tu4Zhian Li5Department of Oncological Surgery, Shaoxing Second HospitalDepartment of Oncological Surgery, Shaoxing Second HospitalDepartment of Early Childhood Education, Shaoxing Vocational and Technical CollegeDepartment of Oncological Surgery, Shaoxing Second HospitalDepartment of Neurosurgery, Shaoxing Central HospitalDepartment of Oncological Surgery, Shaoxing Second HospitalAbstract Marital status proved to be an independent prognostic factor for survival in patients with breast cancer. We therefore strove to explore the impact of dynamic changes in marital status on the prognosis of breast cancer patients. We selected patients meeting the eligibility criteria from the Surveillance, Epidemiology, and End Results cancer database. We then used multivariate Cox proportional hazard regression model to analyze the effect of dynamic changes in marital status on the prognosis of overall survival (OS) and breast cancer-specific special survival (BCSS). Compared with the patients in the Single–Single group and the divorced/separated/widowed–divorced/separated/widowed (DSW–DSW) group, patients in the Married–Married group were significantly associated with better BCSS (HR 1.13, 95% CI: 1.03–1.19, P < 0.001; HR 1.19, 95% CI: 1.14–1.25, P < 0.001, respectively) and OS (HR 1.25, 95% CI: 1.20–1.30, P < 0.001; HR 1.49, 95% CI: 1.45–1.54, P < 0.001, respectively). In contrast to the DSW–DSW group, the Single–Single group and the DSW–Married group showed similar BCSS (HR 0.98, 95% CI: 0.92–1.05, P = 0.660; HR 1.06, 95% CI: 0.97–1.15, P = 0.193, respectively) but better OS (HR 1.14, 95% CI: 1.09–1.19, P < 0.001; HR 1.32, 95% CI: 1.25–1.40, P < 0.001, respectively). Compared with the Single–Single group, the Single–Married group showed significantly better BCSS (HR 1.21, 95% CI: 1.07–1.36, P = 0.003) but no difference in OS (HR 1.08, 95% CI: 0.98–1.18, P = 0.102); In contrast to the Married–DSW group, the Married–Married group exhibited better BCSS (HR 1.11, 95% CI: 1.05–1.18, P < 0.001) and OS (HR 1.27, 95% CI: 1.22–1.32, P < 0.001). Our study demonstrated that, regardless of their previous marital status, married patients had a better prognosis than unmarried patients. Moreover, single patients obtained better survival outcomes than DSW patients. Therefore, it is necessary to proactively provide single and DSW individuals with appropriate social and psychological support that would benefit them.https://doi.org/10.1038/s41598-021-84996-y |
| spellingShingle | Wu Ding Guodong Ruan Yingli Lin Jianming Zhu Chuanjian Tu Zhian Li Dynamic changes in marital status and survival in women with breast cancer: a population-based study Scientific Reports |
| title | Dynamic changes in marital status and survival in women with breast cancer: a population-based study |
| title_full | Dynamic changes in marital status and survival in women with breast cancer: a population-based study |
| title_fullStr | Dynamic changes in marital status and survival in women with breast cancer: a population-based study |
| title_full_unstemmed | Dynamic changes in marital status and survival in women with breast cancer: a population-based study |
| title_short | Dynamic changes in marital status and survival in women with breast cancer: a population-based study |
| title_sort | dynamic changes in marital status and survival in women with breast cancer a population based study |
| url | https://doi.org/10.1038/s41598-021-84996-y |
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