Burkholderia cepacia Complex Vaccines: Where Do We Go from here?
Burkholderia comprises a wide variety of environmental Gram-negative bacteria. Burkholderia cepacia complex (Bcc) includes several Burkholderia species that pose a health hazard as they are able to cause respiratory infections in patients with chronic granulomatous disease and cystic fibrosis. Due t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-04-01
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| Series: | Vaccines |
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| Online Access: | http://www.mdpi.com/2076-393X/4/2/10 |
| _version_ | 1798034083552428032 |
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| author | Gonzalo A. Pradenas Brittany N. Ross Alfredo G. Torres |
| author_facet | Gonzalo A. Pradenas Brittany N. Ross Alfredo G. Torres |
| author_sort | Gonzalo A. Pradenas |
| collection | DOAJ |
| description | Burkholderia comprises a wide variety of environmental Gram-negative bacteria. Burkholderia cepacia complex (Bcc) includes several Burkholderia species that pose a health hazard as they are able to cause respiratory infections in patients with chronic granulomatous disease and cystic fibrosis. Due to the intrinsic resistance to a wide array of antibiotics and naturally occurring immune evasion strategies, treatment of Bcc infections often proves to be unsuccessful. To date, limited work related to vaccine development has been performed for Bcc pathogens. In this review, we have gathered key aspects of Bcc research that have been reported in recent years related to vaccine efforts, virulence, immune responses, and animal models, and use this information to inform the research community of areas of opportunity toward development of a viable Bcc vaccine. |
| first_indexed | 2024-04-11T20:39:20Z |
| format | Article |
| id | doaj.art-e66094111c6c4bd8b9e30aad602dff35 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-11T20:39:20Z |
| publishDate | 2016-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-e66094111c6c4bd8b9e30aad602dff352022-12-22T04:04:17ZengMDPI AGVaccines2076-393X2016-04-01421010.3390/vaccines4020010vaccines4020010Burkholderia cepacia Complex Vaccines: Where Do We Go from here?Gonzalo A. Pradenas0Brittany N. Ross1Alfredo G. Torres2Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USADepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USABurkholderia comprises a wide variety of environmental Gram-negative bacteria. Burkholderia cepacia complex (Bcc) includes several Burkholderia species that pose a health hazard as they are able to cause respiratory infections in patients with chronic granulomatous disease and cystic fibrosis. Due to the intrinsic resistance to a wide array of antibiotics and naturally occurring immune evasion strategies, treatment of Bcc infections often proves to be unsuccessful. To date, limited work related to vaccine development has been performed for Bcc pathogens. In this review, we have gathered key aspects of Bcc research that have been reported in recent years related to vaccine efforts, virulence, immune responses, and animal models, and use this information to inform the research community of areas of opportunity toward development of a viable Bcc vaccine.http://www.mdpi.com/2076-393X/4/2/10Burkholderia cepacia complexvaccinecystic fibrosis |
| spellingShingle | Gonzalo A. Pradenas Brittany N. Ross Alfredo G. Torres Burkholderia cepacia Complex Vaccines: Where Do We Go from here? Vaccines Burkholderia cepacia complex vaccine cystic fibrosis |
| title | Burkholderia cepacia Complex Vaccines: Where Do We Go from here? |
| title_full | Burkholderia cepacia Complex Vaccines: Where Do We Go from here? |
| title_fullStr | Burkholderia cepacia Complex Vaccines: Where Do We Go from here? |
| title_full_unstemmed | Burkholderia cepacia Complex Vaccines: Where Do We Go from here? |
| title_short | Burkholderia cepacia Complex Vaccines: Where Do We Go from here? |
| title_sort | burkholderia cepacia complex vaccines where do we go from here |
| topic | Burkholderia cepacia complex vaccine cystic fibrosis |
| url | http://www.mdpi.com/2076-393X/4/2/10 |
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