Large cell neuroendocrine tumor of the lung: A diagnostic challenge
Lung neuroendocrine carcinoma (NEC) is a rare heterogeneous carcinoma with NE cells in the pulmonary and bronchial epithelium as the site of origin. We describe a case of large cell NEC (LCNEC) in a 55-year-old male, smoker with 25 pack-years, who presented with cough, dyspnea, hemoptysis, and loss...
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2020-01-01
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| Series: | Indian Journal of Respiratory Care |
| Subjects: | |
| Online Access: | http://www.ijrconline.org/article.asp?issn=2277-9019;year=2020;volume=9;issue=1;spage=97;epage=99;aulast=Gali |
| _version_ | 1797694480446390272 |
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| author | Jayasri Helen Gali Harsha Vardhana Varma |
| author_facet | Jayasri Helen Gali Harsha Vardhana Varma |
| author_sort | Jayasri Helen Gali |
| collection | DOAJ |
| description | Lung neuroendocrine carcinoma (NEC) is a rare heterogeneous carcinoma with NE cells in the pulmonary and bronchial epithelium as the site of origin. We describe a case of large cell NEC (LCNEC) in a 55-year-old male, smoker with 25 pack-years, who presented with cough, dyspnea, hemoptysis, and loss of appetite for 6 months. There was no diabetes, hypertension, asthma, chronic obstructive pulmonary disease, tuberculosis, or contact with tuberculosis or malignancy. The presence of a large homogenous mass lesion in the right chest on chest X-ray, further clearly defined on chest computed tomography scan (130/94/123 mm) was suggestive of huge mass. There was no mediastinal or pleural involvement. Possibility of LCNEC was suspected as the ultrasound-guided biopsy was indicating the presence of poorly differentiated carcinoma. Immunohistochemistry was negative for thyroid transcription factor, cytokeratin 7 but was positive for synaptophysin and P40, suggestive of high-grade LCNECs. It was in T4N0M0, stage 3A and treatment with combination chemotherapy was initiated. |
| first_indexed | 2024-03-12T02:57:35Z |
| format | Article |
| id | doaj.art-e664ff21dd064059982f9d6eff70eef0 |
| institution | Directory Open Access Journal |
| issn | 2277-9019 2321-4899 |
| language | English |
| last_indexed | 2024-03-12T02:57:35Z |
| publishDate | 2020-01-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Respiratory Care |
| spelling | doaj.art-e664ff21dd064059982f9d6eff70eef02023-09-03T15:12:32ZengJaypee Brothers Medical PublisherIndian Journal of Respiratory Care2277-90192321-48992020-01-0191979910.4103/ijrc.ijrc_7_19Large cell neuroendocrine tumor of the lung: A diagnostic challengeJayasri Helen GaliHarsha Vardhana VarmaLung neuroendocrine carcinoma (NEC) is a rare heterogeneous carcinoma with NE cells in the pulmonary and bronchial epithelium as the site of origin. We describe a case of large cell NEC (LCNEC) in a 55-year-old male, smoker with 25 pack-years, who presented with cough, dyspnea, hemoptysis, and loss of appetite for 6 months. There was no diabetes, hypertension, asthma, chronic obstructive pulmonary disease, tuberculosis, or contact with tuberculosis or malignancy. The presence of a large homogenous mass lesion in the right chest on chest X-ray, further clearly defined on chest computed tomography scan (130/94/123 mm) was suggestive of huge mass. There was no mediastinal or pleural involvement. Possibility of LCNEC was suspected as the ultrasound-guided biopsy was indicating the presence of poorly differentiated carcinoma. Immunohistochemistry was negative for thyroid transcription factor, cytokeratin 7 but was positive for synaptophysin and P40, suggestive of high-grade LCNECs. It was in T4N0M0, stage 3A and treatment with combination chemotherapy was initiated.http://www.ijrconline.org/article.asp?issn=2277-9019;year=2020;volume=9;issue=1;spage=97;epage=99;aulast=Galiimmunohistochemistrylarge cell neuroendocrine tumorlung neuroendocrine tumor |
| spellingShingle | Jayasri Helen Gali Harsha Vardhana Varma Large cell neuroendocrine tumor of the lung: A diagnostic challenge Indian Journal of Respiratory Care immunohistochemistry large cell neuroendocrine tumor lung neuroendocrine tumor |
| title | Large cell neuroendocrine tumor of the lung: A diagnostic challenge |
| title_full | Large cell neuroendocrine tumor of the lung: A diagnostic challenge |
| title_fullStr | Large cell neuroendocrine tumor of the lung: A diagnostic challenge |
| title_full_unstemmed | Large cell neuroendocrine tumor of the lung: A diagnostic challenge |
| title_short | Large cell neuroendocrine tumor of the lung: A diagnostic challenge |
| title_sort | large cell neuroendocrine tumor of the lung a diagnostic challenge |
| topic | immunohistochemistry large cell neuroendocrine tumor lung neuroendocrine tumor |
| url | http://www.ijrconline.org/article.asp?issn=2277-9019;year=2020;volume=9;issue=1;spage=97;epage=99;aulast=Gali |
| work_keys_str_mv | AT jayasrihelengali largecellneuroendocrinetumorofthelungadiagnosticchallenge AT harshavardhanavarma largecellneuroendocrinetumorofthelungadiagnosticchallenge |