Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering
This paper addresses the potential of self-made polyester-urethane filament as a candidate for Fused Filament Fabrication (FFF)-based 3D printing (3DP) in medical applications. Since the industry does not provide many ready-made solutions of medical-grade polyurethane filaments, we undertook researc...
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MDPI AG
2020-10-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/13/19/4457 |
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| author | Agnieszka Haryńska Iga Carayon Paulina Kosmela Anna Brillowska-Dąbrowska Marcin Łapiński Justyna Kucińska-Lipka Helena Janik |
| author_facet | Agnieszka Haryńska Iga Carayon Paulina Kosmela Anna Brillowska-Dąbrowska Marcin Łapiński Justyna Kucińska-Lipka Helena Janik |
| author_sort | Agnieszka Haryńska |
| collection | DOAJ |
| description | This paper addresses the potential of self-made polyester-urethane filament as a candidate for Fused Filament Fabrication (FFF)-based 3D printing (3DP) in medical applications. Since the industry does not provide many ready-made solutions of medical-grade polyurethane filaments, we undertook research aimed at presenting the process of thermoplastic polyurethane (TPU) filament formation, detailed characteristics, and 3DP of specially designed elastic porous structures as candidates in cancellous tissue engineering. Additionally, we examined whether 3D printing affects the structure and thermal stability of the filament. According to the obtained results, the processing parameters leading to the formation of high-quality TPU filament (TPU_F) were captured. The results showed that TPU_F remains stable under the FFF 3DP conditions. The series of in vitro studies involving long- and short-term degradation (0.1 M phosphate-buffered saline (PBS); 5 M sodium hydroxide (NaOH)), cytotoxicity (ISO 10993:5) and bioactivity (simulated body fluid (SBF) incubation), showed that TPU printouts possessing degradability of long-term degradable tissue constructs, are biocompatible and susceptible to mineralization in terms of hydroxyapatite (HAp) formation during SBF exposure. The formation of HAp on the surface of the specially designed porous tissue structures (PTS) was confirmed by scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDS) studies. The compression test of PTS showed that the samples were strengthened due to SBF exposure and deposited HAp on their surface. Moreover, the determined values of the tensile strength (~30 MPa), Young’s modulus (~0.2 GPa), and compression strength (~1.1 MPa) allowed pre-consideration of TPU_F for FFF 3DP of cancellous bone tissue structures. |
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| id | doaj.art-e665909c39144fc0b35d1b15fa4a1c80 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T15:47:16Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-e665909c39144fc0b35d1b15fa4a1c802023-11-20T16:22:24ZengMDPI AGMaterials1996-19442020-10-011319445710.3390/ma13194457Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue EngineeringAgnieszka Haryńska0Iga Carayon1Paulina Kosmela2Anna Brillowska-Dąbrowska3Marcin Łapiński4Justyna Kucińska-Lipka5Helena Janik6Department of Polymers Technology, Faculty of Chemistry, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80-233 Gdansk, PolandDepartment of Polymers Technology, Faculty of Chemistry, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80-233 Gdansk, PolandDepartment of Polymers Technology, Faculty of Chemistry, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80-233 Gdansk, PolandDepartment of Molecular Biotechnology and Microbiology, Faculty of Chemistry, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80-233 Gdansk, PolandInstitute of Nanotechnology and Materials Science, Faculty of Applied Physics and Mathematics, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80-233 Gdansk, PolandDepartment of Polymers Technology, Faculty of Chemistry, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80-233 Gdansk, PolandDepartment of Polymers Technology, Faculty of Chemistry, Gdansk University of Technology (GUT), Narutowicza Street 11/12, 80-233 Gdansk, PolandThis paper addresses the potential of self-made polyester-urethane filament as a candidate for Fused Filament Fabrication (FFF)-based 3D printing (3DP) in medical applications. Since the industry does not provide many ready-made solutions of medical-grade polyurethane filaments, we undertook research aimed at presenting the process of thermoplastic polyurethane (TPU) filament formation, detailed characteristics, and 3DP of specially designed elastic porous structures as candidates in cancellous tissue engineering. Additionally, we examined whether 3D printing affects the structure and thermal stability of the filament. According to the obtained results, the processing parameters leading to the formation of high-quality TPU filament (TPU_F) were captured. The results showed that TPU_F remains stable under the FFF 3DP conditions. The series of in vitro studies involving long- and short-term degradation (0.1 M phosphate-buffered saline (PBS); 5 M sodium hydroxide (NaOH)), cytotoxicity (ISO 10993:5) and bioactivity (simulated body fluid (SBF) incubation), showed that TPU printouts possessing degradability of long-term degradable tissue constructs, are biocompatible and susceptible to mineralization in terms of hydroxyapatite (HAp) formation during SBF exposure. The formation of HAp on the surface of the specially designed porous tissue structures (PTS) was confirmed by scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDS) studies. The compression test of PTS showed that the samples were strengthened due to SBF exposure and deposited HAp on their surface. Moreover, the determined values of the tensile strength (~30 MPa), Young’s modulus (~0.2 GPa), and compression strength (~1.1 MPa) allowed pre-consideration of TPU_F for FFF 3DP of cancellous bone tissue structures.https://www.mdpi.com/1996-1944/13/19/4457filament formationFused Filament Fabrication3D printingthermoplastic polyurethanetissue scaffoldsmaterial characterization |
| spellingShingle | Agnieszka Haryńska Iga Carayon Paulina Kosmela Anna Brillowska-Dąbrowska Marcin Łapiński Justyna Kucińska-Lipka Helena Janik Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering Materials filament formation Fused Filament Fabrication 3D printing thermoplastic polyurethane tissue scaffolds material characterization |
| title | Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering |
| title_full | Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering |
| title_fullStr | Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering |
| title_full_unstemmed | Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering |
| title_short | Processing of Polyester-Urethane Filament and Characterization of FFF 3D Printed Elastic Porous Structures with Potential in Cancellous Bone Tissue Engineering |
| title_sort | processing of polyester urethane filament and characterization of fff 3d printed elastic porous structures with potential in cancellous bone tissue engineering |
| topic | filament formation Fused Filament Fabrication 3D printing thermoplastic polyurethane tissue scaffolds material characterization |
| url | https://www.mdpi.com/1996-1944/13/19/4457 |
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