Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study
BackgroundThe pathogenesis of eosinophilic dermatosis of hematologic malignancy (EDHM) is poorly understood. Previously thought to be a hypersensitivity reaction to insect bites, immune dysregulation and cytokine imbalance are now thought to be responsible. Its prognostic significance is unclear.Obj...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1231003/full |
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| author | Andrea Michelerio Andrea Michelerio Carlo Tomasini Carlo Tomasini Giacomo Fiandrino Giacomo Fiandrino Mara De Amici Marzia Varettoni Marzia Varettoni Irene Defrancesco Irene Defrancesco Chiara Cavalloni Chiara Cavalloni Valeria Brazzelli Valeria Brazzelli Federica Derlino Federica Derlino Marco Paulli Marco Paulli Luca Arcaini Luca Arcaini Camilla Vassallo |
| author_facet | Andrea Michelerio Andrea Michelerio Carlo Tomasini Carlo Tomasini Giacomo Fiandrino Giacomo Fiandrino Mara De Amici Marzia Varettoni Marzia Varettoni Irene Defrancesco Irene Defrancesco Chiara Cavalloni Chiara Cavalloni Valeria Brazzelli Valeria Brazzelli Federica Derlino Federica Derlino Marco Paulli Marco Paulli Luca Arcaini Luca Arcaini Camilla Vassallo |
| author_sort | Andrea Michelerio |
| collection | DOAJ |
| description | BackgroundThe pathogenesis of eosinophilic dermatosis of hematologic malignancy (EDHM) is poorly understood. Previously thought to be a hypersensitivity reaction to insect bites, immune dysregulation and cytokine imbalance are now thought to be responsible. Its prognostic significance is unclear.ObjectiveTo describe the clinical, pathological and immunological findings in a series of oncohematological patients with EDHM.MethodsAn observational prospective cohort study of oncohematological patients receiving a diagnosis of EDHM between April 2017 and December 2018.ResultsA total of 15 patients with EDHM (10 females and 5 males) were identified among 422 oncohematological patients. Disease presentation varied from firm erythematous papules to more polymorphic presentations. The lesions were most prevalent on the exposed sites, 8/15 patients recalled an insect bite. Lesion seasonality was reported in 13/15 patients. IgE levels were elevated in six patients, circulating IL-4 and IL-5 were within a normal range. Twelve out of 15 patients developed skin manifestations after chemotherapy. The infiltrate could be eosinophil-rich or lymphocytic-rich. Interestingly, the histopathologic findings were in accordance with arthropod bites.ConclusionA role for insect bites in EDHM is supported by our findings. EDHM may be related to aggressive hematologic disease. |
| first_indexed | 2024-03-12T16:56:13Z |
| format | Article |
| id | doaj.art-e666a6bae60a45e69e5d35df29128688 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T16:56:13Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e666a6bae60a45e69e5d35df291286882023-08-08T07:34:32ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-08-011010.3389/fmed.2023.12310031231003Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological studyAndrea Michelerio0Andrea Michelerio1Carlo Tomasini2Carlo Tomasini3Giacomo Fiandrino4Giacomo Fiandrino5Mara De Amici6Marzia Varettoni7Marzia Varettoni8Irene Defrancesco9Irene Defrancesco10Chiara Cavalloni11Chiara Cavalloni12Valeria Brazzelli13Valeria Brazzelli14Federica Derlino15Federica Derlino16Marco Paulli17Marco Paulli18Luca Arcaini19Luca Arcaini20Camilla Vassallo21Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, ItalyDermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, ItalyDermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyDepartment of Pathology, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyLaboratory of Immuno-Allergology of Clinical Chemistry and Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyDivision of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyDivision of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyDivision of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, ItalyDermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, ItalyDermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyDepartment of Pathology, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyDivision of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDermatology Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyBackgroundThe pathogenesis of eosinophilic dermatosis of hematologic malignancy (EDHM) is poorly understood. Previously thought to be a hypersensitivity reaction to insect bites, immune dysregulation and cytokine imbalance are now thought to be responsible. Its prognostic significance is unclear.ObjectiveTo describe the clinical, pathological and immunological findings in a series of oncohematological patients with EDHM.MethodsAn observational prospective cohort study of oncohematological patients receiving a diagnosis of EDHM between April 2017 and December 2018.ResultsA total of 15 patients with EDHM (10 females and 5 males) were identified among 422 oncohematological patients. Disease presentation varied from firm erythematous papules to more polymorphic presentations. The lesions were most prevalent on the exposed sites, 8/15 patients recalled an insect bite. Lesion seasonality was reported in 13/15 patients. IgE levels were elevated in six patients, circulating IL-4 and IL-5 were within a normal range. Twelve out of 15 patients developed skin manifestations after chemotherapy. The infiltrate could be eosinophil-rich or lymphocytic-rich. Interestingly, the histopathologic findings were in accordance with arthropod bites.ConclusionA role for insect bites in EDHM is supported by our findings. EDHM may be related to aggressive hematologic disease.https://www.frontiersin.org/articles/10.3389/fmed.2023.1231003/fulleosinophilic dermatosisinsect bitesB cell chronic lymphocytic leukemianon-Hodgkin lymphomaeosinophils |
| spellingShingle | Andrea Michelerio Andrea Michelerio Carlo Tomasini Carlo Tomasini Giacomo Fiandrino Giacomo Fiandrino Mara De Amici Marzia Varettoni Marzia Varettoni Irene Defrancesco Irene Defrancesco Chiara Cavalloni Chiara Cavalloni Valeria Brazzelli Valeria Brazzelli Federica Derlino Federica Derlino Marco Paulli Marco Paulli Luca Arcaini Luca Arcaini Camilla Vassallo Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study Frontiers in Medicine eosinophilic dermatosis insect bites B cell chronic lymphocytic leukemia non-Hodgkin lymphoma eosinophils |
| title | Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study |
| title_full | Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study |
| title_fullStr | Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study |
| title_full_unstemmed | Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study |
| title_short | Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study |
| title_sort | eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia non hodgkin s b lymphoma a single center prospective clinico pathological study |
| topic | eosinophilic dermatosis insect bites B cell chronic lymphocytic leukemia non-Hodgkin lymphoma eosinophils |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1231003/full |
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