Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives
Meniscus tissue engineering (MTE) has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, as they possess tunable properties that allow them to mimic native extracellular matrices and provide a suita...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Online Access: | https://www.mdpi.com/2310-2861/10/2/114 |
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| author | Zhuxing Zhou Jiajie Wang Chaoqian Jiang Kaiwang Xu Tengjing Xu Xinning Yu Jinghua Fang Yanyu Yang Xuesong Dai |
| author_facet | Zhuxing Zhou Jiajie Wang Chaoqian Jiang Kaiwang Xu Tengjing Xu Xinning Yu Jinghua Fang Yanyu Yang Xuesong Dai |
| author_sort | Zhuxing Zhou |
| collection | DOAJ |
| description | Meniscus tissue engineering (MTE) has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, as they possess tunable properties that allow them to mimic native extracellular matrices and provide a suitable microenvironment. Additionally, hydrogels can be minimally invasively injected and can be adjusted to match the shape of the implant site. They can conveniently and effectively deliver bioactive additives and demonstrate good compatibility with other functional materials. These inherent qualities have made hydrogel a promising candidate for therapeutic approaches in meniscus repair and regeneration. This article provides a comprehensive review of the advancements made in the research on hydrogel application for meniscus tissue engineering. Firstly, the biomaterials and crosslinking strategies used in the formation of hydrogels are summarized and analyzed. Subsequently, the role of therapeutic additives, including cells, growth factors, and other active products, in facilitating meniscus repair and regeneration is thoroughly discussed. Furthermore, we summarize the key issues for designing hydrogels used in MTE. Finally, we conclude with the current challenges encountered by hydrogel applications and suggest potential solutions for addressing these challenges in the field of MTE. We hope this review provides a resource for researchers and practitioners interested in this field, thereby facilitating the exploration of new design possibilities. |
| first_indexed | 2024-03-07T22:32:08Z |
| format | Article |
| id | doaj.art-e666d23e290e4345ba8c1bdf60b8abbb |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-07T22:32:08Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-e666d23e290e4345ba8c1bdf60b8abbb2024-02-23T15:17:29ZengMDPI AGGels2310-28612024-02-0110211410.3390/gels10020114Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic AdditivesZhuxing Zhou0Jiajie Wang1Chaoqian Jiang2Kaiwang Xu3Tengjing Xu4Xinning Yu5Jinghua Fang6Yanyu Yang7Xuesong Dai8Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, ChinaSchool of Materials and Engineering, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, ChinaSchool of Materials and Engineering, Zhengzhou University, Zhengzhou 450001, ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, ChinaMeniscus tissue engineering (MTE) has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, as they possess tunable properties that allow them to mimic native extracellular matrices and provide a suitable microenvironment. Additionally, hydrogels can be minimally invasively injected and can be adjusted to match the shape of the implant site. They can conveniently and effectively deliver bioactive additives and demonstrate good compatibility with other functional materials. These inherent qualities have made hydrogel a promising candidate for therapeutic approaches in meniscus repair and regeneration. This article provides a comprehensive review of the advancements made in the research on hydrogel application for meniscus tissue engineering. Firstly, the biomaterials and crosslinking strategies used in the formation of hydrogels are summarized and analyzed. Subsequently, the role of therapeutic additives, including cells, growth factors, and other active products, in facilitating meniscus repair and regeneration is thoroughly discussed. Furthermore, we summarize the key issues for designing hydrogels used in MTE. Finally, we conclude with the current challenges encountered by hydrogel applications and suggest potential solutions for addressing these challenges in the field of MTE. We hope this review provides a resource for researchers and practitioners interested in this field, thereby facilitating the exploration of new design possibilities.https://www.mdpi.com/2310-2861/10/2/114hydrogelbiomaterialcrosslinkingtherapeutic effectmeniscusrepair |
| spellingShingle | Zhuxing Zhou Jiajie Wang Chaoqian Jiang Kaiwang Xu Tengjing Xu Xinning Yu Jinghua Fang Yanyu Yang Xuesong Dai Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives Gels hydrogel biomaterial crosslinking therapeutic effect meniscus repair |
| title | Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives |
| title_full | Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives |
| title_fullStr | Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives |
| title_full_unstemmed | Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives |
| title_short | Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives |
| title_sort | advances in hydrogels for meniscus tissue engineering a focus on biomaterials crosslinking therapeutic additives |
| topic | hydrogel biomaterial crosslinking therapeutic effect meniscus repair |
| url | https://www.mdpi.com/2310-2861/10/2/114 |
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