Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model
Gut microbes are closely associated with disease onset and improvement. However, the effects of gut microbes on the occurrence, prevention, and treatment of benign prostatic hyperplasia (BPH) are still unclear. We investigated the alteration of gut microbiota with implications for the diagnosis, pre...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5904 |
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| author | Jinho An Youngcheon Song Sangbum Kim Hyunseok Kong Kyungjae Kim |
| author_facet | Jinho An Youngcheon Song Sangbum Kim Hyunseok Kong Kyungjae Kim |
| author_sort | Jinho An |
| collection | DOAJ |
| description | Gut microbes are closely associated with disease onset and improvement. However, the effects of gut microbes on the occurrence, prevention, and treatment of benign prostatic hyperplasia (BPH) are still unclear. We investigated the alteration of gut microbiota with implications for the diagnosis, prevention, and treatment of BPH and identified correlations among various indicators, including hormone indicators, apoptosis markers in BPH, and finasteride treatment models. BPH induction altered the abundance of <i>Lactobacillus</i>, <i>Flavonifractor</i>, <i>Acetatifactor</i>, <i>Oscillibacter</i>, <i>Pseudoflavonifractor</i>, <i>Intestinimonas</i>, and <i>Butyricimonas</i> genera, which are related to BPH indicators. Among these, the altered abundance of <i>Lactobacillus</i> and <i>Acetatifactor</i> was associated with the promotion and inhibition of prostate apoptosis, respectively. Finasteride treatment altered the abundance of <i>Barnesiella</i>, <i>Acetatifactor</i>, <i>Butyricimonas</i>, <i>Desulfovibrio</i>, <i>Anaerobacterium</i>, and <i>Robinsoniella</i> genera, which are related to BPH indicators. Among these, altered abundances of <i>Desulfovibrio</i> and <i>Acetatifactor</i> were associated with the promotion and inhibition of prostate apoptosis, respectively. In addition, the abundances of <i>Lactobacillus</i> and <i>Acetatifactor</i> were normalized after finasteride treatment. In conclusion, the association between apoptosis and altered abundances of <i>Lactobacillus</i> and <i>Acetatifactor</i>, among other gut microbes, suggests their potential utility in the diagnosis, prevention, and treatment of BPH. |
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| language | English |
| last_indexed | 2024-03-11T06:25:31Z |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e66a0431ce574914b7bf785e0f5831f02023-11-17T11:40:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246590410.3390/ijms24065904Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment ModelJinho An0Youngcheon Song1Sangbum Kim2Hyunseok Kong3Kyungjae Kim4College of Pharmacy, Sahmyook University, Seoul 01795, Republic of KoreaCollege of Pharmacy, Sahmyook University, Seoul 01795, Republic of KoreaCollege of Pharmacy, Sahmyook University, Seoul 01795, Republic of KoreaPADAM Natural Material Research Institute, Sahmyook University, Seoul 01795, Republic of KoreaCollege of Pharmacy, Sahmyook University, Seoul 01795, Republic of KoreaGut microbes are closely associated with disease onset and improvement. However, the effects of gut microbes on the occurrence, prevention, and treatment of benign prostatic hyperplasia (BPH) are still unclear. We investigated the alteration of gut microbiota with implications for the diagnosis, prevention, and treatment of BPH and identified correlations among various indicators, including hormone indicators, apoptosis markers in BPH, and finasteride treatment models. BPH induction altered the abundance of <i>Lactobacillus</i>, <i>Flavonifractor</i>, <i>Acetatifactor</i>, <i>Oscillibacter</i>, <i>Pseudoflavonifractor</i>, <i>Intestinimonas</i>, and <i>Butyricimonas</i> genera, which are related to BPH indicators. Among these, the altered abundance of <i>Lactobacillus</i> and <i>Acetatifactor</i> was associated with the promotion and inhibition of prostate apoptosis, respectively. Finasteride treatment altered the abundance of <i>Barnesiella</i>, <i>Acetatifactor</i>, <i>Butyricimonas</i>, <i>Desulfovibrio</i>, <i>Anaerobacterium</i>, and <i>Robinsoniella</i> genera, which are related to BPH indicators. Among these, altered abundances of <i>Desulfovibrio</i> and <i>Acetatifactor</i> were associated with the promotion and inhibition of prostate apoptosis, respectively. In addition, the abundances of <i>Lactobacillus</i> and <i>Acetatifactor</i> were normalized after finasteride treatment. In conclusion, the association between apoptosis and altered abundances of <i>Lactobacillus</i> and <i>Acetatifactor</i>, among other gut microbes, suggests their potential utility in the diagnosis, prevention, and treatment of BPH.https://www.mdpi.com/1422-0067/24/6/5904gut microbesbenign prostatic hyperplasiaapoptosisfinasteride<i>Lactobacillus</i><i>Acetatifactor</i> |
| spellingShingle | Jinho An Youngcheon Song Sangbum Kim Hyunseok Kong Kyungjae Kim Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model International Journal of Molecular Sciences gut microbes benign prostatic hyperplasia apoptosis finasteride <i>Lactobacillus</i> <i>Acetatifactor</i> |
| title | Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model |
| title_full | Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model |
| title_fullStr | Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model |
| title_full_unstemmed | Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model |
| title_short | Alteration of Gut Microbes in Benign Prostatic Hyperplasia Model and Finasteride Treatment Model |
| title_sort | alteration of gut microbes in benign prostatic hyperplasia model and finasteride treatment model |
| topic | gut microbes benign prostatic hyperplasia apoptosis finasteride <i>Lactobacillus</i> <i>Acetatifactor</i> |
| url | https://www.mdpi.com/1422-0067/24/6/5904 |
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