Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease
The pathogenesis of Alzheimer’s disease (AD) remains unknown till today, hindering the research and development of AD therapeutics and diagnostics. Circulating extracellular vesicles (EVs) can be utilized as a new window to spy upon AD pathogenesis. Altered microRNA profiles were noted in both the c...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.955511/full |
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| author | Yi Wang Ping Yuan Lu Ding Jie Zhu Xinrui Qi Yanyan Zhang Yunxia Li Xiaohuan Xia Xiaohuan Xia Xiaohuan Xia Jialin C. Zheng Jialin C. Zheng Jialin C. Zheng Jialin C. Zheng |
| author_facet | Yi Wang Ping Yuan Lu Ding Jie Zhu Xinrui Qi Yanyan Zhang Yunxia Li Xiaohuan Xia Xiaohuan Xia Xiaohuan Xia Jialin C. Zheng Jialin C. Zheng Jialin C. Zheng Jialin C. Zheng |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | The pathogenesis of Alzheimer’s disease (AD) remains unknown till today, hindering the research and development of AD therapeutics and diagnostics. Circulating extracellular vesicles (EVs) can be utilized as a new window to spy upon AD pathogenesis. Altered microRNA profiles were noted in both the cerebrospinal fluid (CSF)- and blood-isolated EVs of AD patients, implying the outstanding potential of circulating EV-containing miRNAs (CEmiRs) to serve as important regulators in AD pathogenesis. Although several CEmiRs were found to play a part in AD, the association of globally altered miRNA profiles in patients’ serum-derived EVs with AD pathogenesis remains unclear. In this study, we first investigated the miRNA profile in serum-derived EVs from AD, mild cognitive impairment (MCI) patients, and healthy individuals. We observed differential expression patterns of CEmiRs and classified them into 10 clusters. We identified the predicted targets of these differentially expressed CEmiRs (DECEmiRs) and analyzed their biological functions and interactions. Our study revealed the temporal regulation of complex and precise signaling networks on AD pathogenesis, shedding light on the development of novel therapeutic strategies, including multi-target drug combination for AD treatment. |
| first_indexed | 2024-04-12T16:26:04Z |
| format | Article |
| id | doaj.art-e66a911e4a004964b484e8c9719ccd96 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-12T16:26:04Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-e66a911e4a004964b484e8c9719ccd962022-12-22T03:25:23ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-10-011610.3389/fncel.2022.955511955511Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s diseaseYi Wang0Ping Yuan1Lu Ding2Jie Zhu3Xinrui Qi4Yanyan Zhang5Yunxia Li6Xiaohuan Xia7Xiaohuan Xia8Xiaohuan Xia9Jialin C. Zheng10Jialin C. Zheng11Jialin C. Zheng12Jialin C. Zheng13Translational Research Center, Shanghai Yangzhi Rehabilitation Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaDepartment of Cardio-Pulmonary Circulation, School of Medicine, Shanghai Pulmonary Hospital, Tongji University, Shanghai, ChinaCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaCenter for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaCenter for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaDepartment of Neurology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaShanghai Frontiers Science Center of Nanocatalytic Medicine, Tongji University, Shanghai, ChinaCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, ChinaShanghai Frontiers Science Center of Nanocatalytic Medicine, Tongji University, Shanghai, ChinaCollaborative Innovation Center for Brain Science, Tongji University, Shanghai, ChinaThe pathogenesis of Alzheimer’s disease (AD) remains unknown till today, hindering the research and development of AD therapeutics and diagnostics. Circulating extracellular vesicles (EVs) can be utilized as a new window to spy upon AD pathogenesis. Altered microRNA profiles were noted in both the cerebrospinal fluid (CSF)- and blood-isolated EVs of AD patients, implying the outstanding potential of circulating EV-containing miRNAs (CEmiRs) to serve as important regulators in AD pathogenesis. Although several CEmiRs were found to play a part in AD, the association of globally altered miRNA profiles in patients’ serum-derived EVs with AD pathogenesis remains unclear. In this study, we first investigated the miRNA profile in serum-derived EVs from AD, mild cognitive impairment (MCI) patients, and healthy individuals. We observed differential expression patterns of CEmiRs and classified them into 10 clusters. We identified the predicted targets of these differentially expressed CEmiRs (DECEmiRs) and analyzed their biological functions and interactions. Our study revealed the temporal regulation of complex and precise signaling networks on AD pathogenesis, shedding light on the development of novel therapeutic strategies, including multi-target drug combination for AD treatment.https://www.frontiersin.org/articles/10.3389/fncel.2022.955511/fullExosomemiRNAAlzheimer’s diseaseneurodegenerationserum |
| spellingShingle | Yi Wang Ping Yuan Lu Ding Jie Zhu Xinrui Qi Yanyan Zhang Yunxia Li Xiaohuan Xia Xiaohuan Xia Xiaohuan Xia Jialin C. Zheng Jialin C. Zheng Jialin C. Zheng Jialin C. Zheng Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease Frontiers in Cellular Neuroscience Exosome miRNA Alzheimer’s disease neurodegeneration serum |
| title | Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease |
| title_full | Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease |
| title_fullStr | Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease |
| title_full_unstemmed | Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease |
| title_short | Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease |
| title_sort | circulating extracellular vesicle containing micrornas reveal potential pathogenesis of alzheimer s disease |
| topic | Exosome miRNA Alzheimer’s disease neurodegeneration serum |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.955511/full |
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