Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study
Personal care and consumer products are extensively used and contain various chemicals that are recognized as endocrine disrupting chemicals. Few epidemiological studies measured the associations of these chemicals and metabolites, especially phenols, with bone health. We measured the associations b...
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| Format: | Article |
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Elsevier
2020-09-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020318201 |
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| author | Ningjian Wang Yuying Wang Haojie Zhang Yuyu Guo Chi Chen Wen Zhang Heng Wan Junli Han Yingli Lu |
| author_facet | Ningjian Wang Yuying Wang Haojie Zhang Yuyu Guo Chi Chen Wen Zhang Heng Wan Junli Han Yingli Lu |
| author_sort | Ningjian Wang |
| collection | DOAJ |
| description | Personal care and consumer products are extensively used and contain various chemicals that are recognized as endocrine disrupting chemicals. Few epidemiological studies measured the associations of these chemicals and metabolites, especially phenols, with bone health. We measured the associations between nine urinary phenol biomarkers and BMD and the subsequent prevalence of osteopenia/osteoporosis. National representative data from US adults aged over 20 years who participated in the National Health and Nutrition Examination Survey from 2005 to 2010 were used. 2,267 men, 1,145 premenopausal women and 1,033 postmenopausal women were included in the final analyses. Bisphenol A, benzophenone-3, triclosan, butylparaben, ethylparaben, methylparaben, propylparaben, 2,5-dichlorophenol and 2,4-dichlorophenol were measured by high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Paraben concentrations, especially ethyl-, methyl- and propylparabens, were related to greater BMD in the femoral neck and intertrochanter and lumbar spine in men and premenopausal women. 2,4-dichlorophenol concentrations was associated with lower BMD and a higher prevalence of osteopenia + osteoporosis in men. Bisphenol A was associated with a higher prevalence of osteopenia + osteoporosis in the lumbar spine in postmenopausal women. Benzophenone-3 tended to be associated with a higher BMD of femur in men and premenopausal women. In conclusion, certain urinary personal care and consumer product chemicals and metabolites were significantly associated with BMD or osteopenia + osteoporosis. These results further indicate that, in future research, determination of the causal relationships and detection of undelying mechanism could be next important directions. |
| first_indexed | 2024-12-22T19:47:34Z |
| format | Article |
| id | doaj.art-e66c46af2d8d42b9857e86bfe2e796e9 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-22T19:47:34Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-e66c46af2d8d42b9857e86bfe2e796e92022-12-21T18:14:39ZengElsevierEnvironment International0160-41202020-09-01142105865Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based studyNingjian Wang0Yuying Wang1Haojie Zhang2Yuyu Guo3Chi Chen4Wen Zhang5Heng Wan6Junli Han7Yingli Lu8Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding author at: Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaPersonal care and consumer products are extensively used and contain various chemicals that are recognized as endocrine disrupting chemicals. Few epidemiological studies measured the associations of these chemicals and metabolites, especially phenols, with bone health. We measured the associations between nine urinary phenol biomarkers and BMD and the subsequent prevalence of osteopenia/osteoporosis. National representative data from US adults aged over 20 years who participated in the National Health and Nutrition Examination Survey from 2005 to 2010 were used. 2,267 men, 1,145 premenopausal women and 1,033 postmenopausal women were included in the final analyses. Bisphenol A, benzophenone-3, triclosan, butylparaben, ethylparaben, methylparaben, propylparaben, 2,5-dichlorophenol and 2,4-dichlorophenol were measured by high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Paraben concentrations, especially ethyl-, methyl- and propylparabens, were related to greater BMD in the femoral neck and intertrochanter and lumbar spine in men and premenopausal women. 2,4-dichlorophenol concentrations was associated with lower BMD and a higher prevalence of osteopenia + osteoporosis in men. Bisphenol A was associated with a higher prevalence of osteopenia + osteoporosis in the lumbar spine in postmenopausal women. Benzophenone-3 tended to be associated with a higher BMD of femur in men and premenopausal women. In conclusion, certain urinary personal care and consumer product chemicals and metabolites were significantly associated with BMD or osteopenia + osteoporosis. These results further indicate that, in future research, determination of the causal relationships and detection of undelying mechanism could be next important directions.http://www.sciencedirect.com/science/article/pii/S0160412020318201PhenolsUrinary metabolitesBone mineral densityOsteoporosisOsteopeniaNHANES |
| spellingShingle | Ningjian Wang Yuying Wang Haojie Zhang Yuyu Guo Chi Chen Wen Zhang Heng Wan Junli Han Yingli Lu Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study Environment International Phenols Urinary metabolites Bone mineral density Osteoporosis Osteopenia NHANES |
| title | Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study |
| title_full | Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study |
| title_fullStr | Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study |
| title_full_unstemmed | Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study |
| title_short | Association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites: A national-representative, population-based study |
| title_sort | association of bone mineral density with nine urinary personal care and consumer product chemicals and metabolites a national representative population based study |
| topic | Phenols Urinary metabolites Bone mineral density Osteoporosis Osteopenia NHANES |
| url | http://www.sciencedirect.com/science/article/pii/S0160412020318201 |
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