Hyperalgesia-Type Response Reveals No Difference in Pain-Related Behavior Between Wistar and Sprague-Dawley Rats
The experience of pain is variable among certain cultures, ethnical groups and among individuals. This variability can be explained by environmental influence, genetic predisposition and plasticity of the existing neuronal pathways. The purpose of this study was to examine a strain-related differen...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2007-05-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3065 |
| _version_ | 1797260786609946624 |
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| author | Katarina Vukojević Sanja Lovrić-Kojundžić Damir Sapunar |
| author_facet | Katarina Vukojević Sanja Lovrić-Kojundžić Damir Sapunar |
| author_sort | Katarina Vukojević |
| collection | DOAJ |
| description |
The experience of pain is variable among certain cultures, ethnical groups and among individuals. This variability can be explained by environmental influence, genetic predisposition and plasticity of the existing neuronal pathways. The purpose of this study was to examine a strain-related difference in pain sensitivity between Wistar and Sprague-Dawley rats strains and if there was a difference, could it be overcomes with the robust test. Mechanical sensitivity e.g. existence of paw withdrawal and complex hyperalgesia-type response after needle stimuli has been measured. Both hindpaws (middle, medial and lateral part) were stimulated randomly in appropriate intervals. The results did not demonstrate statistically significant strain difference in pain sensitivity, except in the lateral part of the hindpaw where Sprague-Dawley rats were more sensitive. This data emphasize the importance of selecting a robust behavior test that will be used in investigation of peripheral nerve injury and in neuropathic pain research.
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| first_indexed | 2024-04-24T23:30:52Z |
| format | Article |
| id | doaj.art-e66c98638c1f4acfa16d2e94a54a7632 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:30:52Z |
| publishDate | 2007-05-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-e66c98638c1f4acfa16d2e94a54a76322024-03-15T14:42:41ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2007-05-017210.17305/bjbms.2007.3065638Hyperalgesia-Type Response Reveals No Difference in Pain-Related Behavior Between Wistar and Sprague-Dawley RatsKatarina Vukojević0Sanja Lovrić-Kojundžić1Damir Sapunar2Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of SplitDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, University of SplitDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, University of Split The experience of pain is variable among certain cultures, ethnical groups and among individuals. This variability can be explained by environmental influence, genetic predisposition and plasticity of the existing neuronal pathways. The purpose of this study was to examine a strain-related difference in pain sensitivity between Wistar and Sprague-Dawley rats strains and if there was a difference, could it be overcomes with the robust test. Mechanical sensitivity e.g. existence of paw withdrawal and complex hyperalgesia-type response after needle stimuli has been measured. Both hindpaws (middle, medial and lateral part) were stimulated randomly in appropriate intervals. The results did not demonstrate statistically significant strain difference in pain sensitivity, except in the lateral part of the hindpaw where Sprague-Dawley rats were more sensitive. This data emphasize the importance of selecting a robust behavior test that will be used in investigation of peripheral nerve injury and in neuropathic pain research. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3065neuropathic painrat strainstrain diff erencespain modelshyperalgesiapain behavior |
| spellingShingle | Katarina Vukojević Sanja Lovrić-Kojundžić Damir Sapunar Hyperalgesia-Type Response Reveals No Difference in Pain-Related Behavior Between Wistar and Sprague-Dawley Rats Biomolecules & Biomedicine neuropathic pain rat strain strain diff erences pain models hyperalgesia pain behavior |
| title | Hyperalgesia-Type Response Reveals No Difference in Pain-Related Behavior Between Wistar and Sprague-Dawley Rats |
| title_full | Hyperalgesia-Type Response Reveals No Difference in Pain-Related Behavior Between Wistar and Sprague-Dawley Rats |
| title_fullStr | Hyperalgesia-Type Response Reveals No Difference in Pain-Related Behavior Between Wistar and Sprague-Dawley Rats |
| title_full_unstemmed | Hyperalgesia-Type Response Reveals No Difference in Pain-Related Behavior Between Wistar and Sprague-Dawley Rats |
| title_short | Hyperalgesia-Type Response Reveals No Difference in Pain-Related Behavior Between Wistar and Sprague-Dawley Rats |
| title_sort | hyperalgesia type response reveals no difference in pain related behavior between wistar and sprague dawley rats |
| topic | neuropathic pain rat strain strain diff erences pain models hyperalgesia pain behavior |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3065 |
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