Assessment of Frontal Hemispherical Lateralization in Plaque Psoriasis and Atopic Dermatitis
Background: Each brain hemisphere plays a specialized role in cognitive and behavioral processes, known as hemispheric lateralization. In chronic skin diseases, such as plaque psoriasis (Pso) and atopic dermatitis (AD), the degree of lateralization between the frontal hemispheres may provide insight...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/13/4194 |
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| author | Szabolcs Bozsányi Natália Czurkó Melinda Becske Roland Kasek Botond Keve Lázár Mehdi Boostani Fanni Adél Meznerics Klára Farkas Noémi Nóra Varga Lili Gulyás András Bánvölgyi Bence Ágoston Fehér Emese Fejes Kende Lőrincz Anikó Kovács Hunor Gergely Szabolcs Takács Péter Holló Norbert Kiss Norbert Wikonkál Imre Lázár |
| author_facet | Szabolcs Bozsányi Natália Czurkó Melinda Becske Roland Kasek Botond Keve Lázár Mehdi Boostani Fanni Adél Meznerics Klára Farkas Noémi Nóra Varga Lili Gulyás András Bánvölgyi Bence Ágoston Fehér Emese Fejes Kende Lőrincz Anikó Kovács Hunor Gergely Szabolcs Takács Péter Holló Norbert Kiss Norbert Wikonkál Imre Lázár |
| author_sort | Szabolcs Bozsányi |
| collection | DOAJ |
| description | Background: Each brain hemisphere plays a specialized role in cognitive and behavioral processes, known as hemispheric lateralization. In chronic skin diseases, such as plaque psoriasis (Pso) and atopic dermatitis (AD), the degree of lateralization between the frontal hemispheres may provide insight into specific connections between skin diseases and the psyche. This study aims to analyze the hemispherical lateralization, neurovegetative responses, and psychometric characteristics of patients with Pso and AD. Methods: The study included 46 patients with Pso, 56 patients with AD, and 29 healthy control (Ctrl) subjects. The participants underwent frontal electroencephalogram (EEG) measurement, heart rate variability (HRV) assessment, and psychological tests. Statistical analyses were performed using ANOVA, with Bonferroni correction applied for multiple comparisons. Results: This study shows a significant right-lateralized prefrontal activity in both AD patients (<i>p</i> < 0.001) and Pso patients (<i>p</i> = 0.045) compared with Ctrl, with no significant difference between the AD and Pso groups (<i>p</i> = 0.633). AD patients with right-hemispheric dominant prefrontal activation exhibited increased inhibition and avoidance markers, while Pso patients showed elevated sympathetic nervous system activity. Conclusion: Psychophysiological and psychometric data suggest a shared prevalence of right-hemispheric dominance in both AD and Pso patient groups. However, the findings indicate distinct psychodermatological mechanisms in AD and Pso. |
| first_indexed | 2024-03-11T01:38:35Z |
| format | Article |
| id | doaj.art-e66ca9504ac94c2cbaf35b9895d9b748 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T01:38:35Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e66ca9504ac94c2cbaf35b9895d9b7482023-11-18T16:50:24ZengMDPI AGJournal of Clinical Medicine2077-03832023-06-011213419410.3390/jcm12134194Assessment of Frontal Hemispherical Lateralization in Plaque Psoriasis and Atopic DermatitisSzabolcs Bozsányi0Natália Czurkó1Melinda Becske2Roland Kasek3Botond Keve Lázár4Mehdi Boostani5Fanni Adél Meznerics6Klára Farkas7Noémi Nóra Varga8Lili Gulyás9András Bánvölgyi10Bence Ágoston Fehér11Emese Fejes12Kende Lőrincz13Anikó Kovács14Hunor Gergely15Szabolcs Takács16Péter Holló17Norbert Kiss18Norbert Wikonkál19Imre Lázár20Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryInstitute of Behavioral Sciences, Semmelweis University, 1089 Budapest, HungaryInstitute of Behavioral Sciences, Semmelweis University, 1089 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryInstitute of Behavioral Sciences, Semmelweis University, 1089 Budapest, HungarySelye János Doctoral College for Advanced Studies, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryInstitute of Psychology, Faculty of Humanities, Károli Gáspár University of the Reformed Church in Hungary, 1042 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryInstitute of Behavioral Sciences, Semmelweis University, 1089 Budapest, HungaryBackground: Each brain hemisphere plays a specialized role in cognitive and behavioral processes, known as hemispheric lateralization. In chronic skin diseases, such as plaque psoriasis (Pso) and atopic dermatitis (AD), the degree of lateralization between the frontal hemispheres may provide insight into specific connections between skin diseases and the psyche. This study aims to analyze the hemispherical lateralization, neurovegetative responses, and psychometric characteristics of patients with Pso and AD. Methods: The study included 46 patients with Pso, 56 patients with AD, and 29 healthy control (Ctrl) subjects. The participants underwent frontal electroencephalogram (EEG) measurement, heart rate variability (HRV) assessment, and psychological tests. Statistical analyses were performed using ANOVA, with Bonferroni correction applied for multiple comparisons. Results: This study shows a significant right-lateralized prefrontal activity in both AD patients (<i>p</i> < 0.001) and Pso patients (<i>p</i> = 0.045) compared with Ctrl, with no significant difference between the AD and Pso groups (<i>p</i> = 0.633). AD patients with right-hemispheric dominant prefrontal activation exhibited increased inhibition and avoidance markers, while Pso patients showed elevated sympathetic nervous system activity. Conclusion: Psychophysiological and psychometric data suggest a shared prevalence of right-hemispheric dominance in both AD and Pso patient groups. However, the findings indicate distinct psychodermatological mechanisms in AD and Pso.https://www.mdpi.com/2077-0383/12/13/4194psychodermatologyatopic dermatitisplaque psoriasishemispherical lateralizationelectroencephalographyheart rate variability |
| spellingShingle | Szabolcs Bozsányi Natália Czurkó Melinda Becske Roland Kasek Botond Keve Lázár Mehdi Boostani Fanni Adél Meznerics Klára Farkas Noémi Nóra Varga Lili Gulyás András Bánvölgyi Bence Ágoston Fehér Emese Fejes Kende Lőrincz Anikó Kovács Hunor Gergely Szabolcs Takács Péter Holló Norbert Kiss Norbert Wikonkál Imre Lázár Assessment of Frontal Hemispherical Lateralization in Plaque Psoriasis and Atopic Dermatitis Journal of Clinical Medicine psychodermatology atopic dermatitis plaque psoriasis hemispherical lateralization electroencephalography heart rate variability |
| title | Assessment of Frontal Hemispherical Lateralization in Plaque Psoriasis and Atopic Dermatitis |
| title_full | Assessment of Frontal Hemispherical Lateralization in Plaque Psoriasis and Atopic Dermatitis |
| title_fullStr | Assessment of Frontal Hemispherical Lateralization in Plaque Psoriasis and Atopic Dermatitis |
| title_full_unstemmed | Assessment of Frontal Hemispherical Lateralization in Plaque Psoriasis and Atopic Dermatitis |
| title_short | Assessment of Frontal Hemispherical Lateralization in Plaque Psoriasis and Atopic Dermatitis |
| title_sort | assessment of frontal hemispherical lateralization in plaque psoriasis and atopic dermatitis |
| topic | psychodermatology atopic dermatitis plaque psoriasis hemispherical lateralization electroencephalography heart rate variability |
| url | https://www.mdpi.com/2077-0383/12/13/4194 |
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