Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosis
Vascular smooth muscle cells (VSMCs) is a vital accelerator in the late phase of diabetic atherosclerosis, but the underlying mechanism remains unclear. The aim of our study was to investigate whether activin receptor-like kinase 7 (ALK7)-Smad2/3 pathway plays an important role in VSMC apoptosis of...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.926433/full |
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| author | Shengchuan Cao Shengchuan Cao Shengchuan Cao Shengchuan Cao Qiuhuan Yuan Qiuhuan Yuan Qiuhuan Yuan Qiuhuan Yuan Qianqian Dong Qianqian Dong Qianqian Dong Qianqian Dong Xilong Liu Xilong Liu Xilong Liu Xilong Liu Weikang Liu Weikang Liu Weikang Liu Weikang Liu Xiaoxuan Zhai Xiaoxuan Zhai Xiaoxuan Zhai Xiaoxuan Zhai Chuanxin Zhang Chuanxin Zhang Chuanxin Zhang Chuanxin Zhang Han Liu Han Liu Han Liu Han Liu Mengxiong Tang Mengxiong Tang Mengxiong Tang Mengxiong Tang Shujian Wei Shujian Wei Shujian Wei Shujian Wei Yuguo Chen Yuguo Chen Yuguo Chen Yuguo Chen |
| author_facet | Shengchuan Cao Shengchuan Cao Shengchuan Cao Shengchuan Cao Qiuhuan Yuan Qiuhuan Yuan Qiuhuan Yuan Qiuhuan Yuan Qianqian Dong Qianqian Dong Qianqian Dong Qianqian Dong Xilong Liu Xilong Liu Xilong Liu Xilong Liu Weikang Liu Weikang Liu Weikang Liu Weikang Liu Xiaoxuan Zhai Xiaoxuan Zhai Xiaoxuan Zhai Xiaoxuan Zhai Chuanxin Zhang Chuanxin Zhang Chuanxin Zhang Chuanxin Zhang Han Liu Han Liu Han Liu Han Liu Mengxiong Tang Mengxiong Tang Mengxiong Tang Mengxiong Tang Shujian Wei Shujian Wei Shujian Wei Shujian Wei Yuguo Chen Yuguo Chen Yuguo Chen Yuguo Chen |
| author_sort | Shengchuan Cao |
| collection | DOAJ |
| description | Vascular smooth muscle cells (VSMCs) is a vital accelerator in the late phase of diabetic atherosclerosis, but the underlying mechanism remains unclear. The aim of our study was to investigate whether activin receptor-like kinase 7 (ALK7)-Smad2/3 pathway plays an important role in VSMC apoptosis of diabetic atherosclerosis. It was shown that ALK7 expression was obviously elevated in the aorta of ApoE−/− mice with type 2 diabetes mellitus. Inhibition of ALK7 expression significantly improved the stability of atherosclerotic plaques and reduced cell apoptosis. Further experiments showed that ALK7 knockdown stabilized atherosclerotic plaques by reducing VSMC apoptosis via activating Smad2/3. Our study uncovered the important role of ALK7-Smad2/3 signaling in VSMCs apoptosis, which might be a potential therapeutic target in diabetic atherosclerosis. |
| first_indexed | 2024-04-13T13:00:07Z |
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| id | doaj.art-e66d704f668a4b569d4205c73f59bafa |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T13:00:07Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-e66d704f668a4b569d4205c73f59bafa2022-12-22T02:45:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.926433926433Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosisShengchuan Cao0Shengchuan Cao1Shengchuan Cao2Shengchuan Cao3Qiuhuan Yuan4Qiuhuan Yuan5Qiuhuan Yuan6Qiuhuan Yuan7Qianqian Dong8Qianqian Dong9Qianqian Dong10Qianqian Dong11Xilong Liu12Xilong Liu13Xilong Liu14Xilong Liu15Weikang Liu16Weikang Liu17Weikang Liu18Weikang Liu19Xiaoxuan Zhai20Xiaoxuan Zhai21Xiaoxuan Zhai22Xiaoxuan Zhai23Chuanxin Zhang24Chuanxin Zhang25Chuanxin Zhang26Chuanxin Zhang27Han Liu28Han Liu29Han Liu30Han Liu31Mengxiong Tang32Mengxiong Tang33Mengxiong Tang34Mengxiong Tang35Shujian Wei36Shujian Wei37Shujian Wei38Shujian Wei39Yuguo Chen40Yuguo Chen41Yuguo Chen42Yuguo Chen43Department of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Emergency Medicine, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Institute of Emergency and Critical Care Medicine of Shandong University, Chest Pain Center, Qilu Hospital of Shandong University, Jinan, ChinaShandong Provincial Engineering Laboratory for Emergency and Critical Care Medicine, Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong Province, Key Laboratory of Emergency and Critical Care Medicine of Shandong Province, Qilu Hospital of Shandong University, Jinan, ChinaThe Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, ChinaVascular smooth muscle cells (VSMCs) is a vital accelerator in the late phase of diabetic atherosclerosis, but the underlying mechanism remains unclear. The aim of our study was to investigate whether activin receptor-like kinase 7 (ALK7)-Smad2/3 pathway plays an important role in VSMC apoptosis of diabetic atherosclerosis. It was shown that ALK7 expression was obviously elevated in the aorta of ApoE−/− mice with type 2 diabetes mellitus. Inhibition of ALK7 expression significantly improved the stability of atherosclerotic plaques and reduced cell apoptosis. Further experiments showed that ALK7 knockdown stabilized atherosclerotic plaques by reducing VSMC apoptosis via activating Smad2/3. Our study uncovered the important role of ALK7-Smad2/3 signaling in VSMCs apoptosis, which might be a potential therapeutic target in diabetic atherosclerosis.https://www.frontiersin.org/articles/10.3389/fphar.2022.926433/fulldiabetic atherosclerosisactivin receptor-like kinase 7vascular smooth muscle cellsapoptosisSmad2/3 |
| spellingShingle | Shengchuan Cao Shengchuan Cao Shengchuan Cao Shengchuan Cao Qiuhuan Yuan Qiuhuan Yuan Qiuhuan Yuan Qiuhuan Yuan Qianqian Dong Qianqian Dong Qianqian Dong Qianqian Dong Xilong Liu Xilong Liu Xilong Liu Xilong Liu Weikang Liu Weikang Liu Weikang Liu Weikang Liu Xiaoxuan Zhai Xiaoxuan Zhai Xiaoxuan Zhai Xiaoxuan Zhai Chuanxin Zhang Chuanxin Zhang Chuanxin Zhang Chuanxin Zhang Han Liu Han Liu Han Liu Han Liu Mengxiong Tang Mengxiong Tang Mengxiong Tang Mengxiong Tang Shujian Wei Shujian Wei Shujian Wei Shujian Wei Yuguo Chen Yuguo Chen Yuguo Chen Yuguo Chen Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosis Frontiers in Pharmacology diabetic atherosclerosis activin receptor-like kinase 7 vascular smooth muscle cells apoptosis Smad2/3 |
| title | Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosis |
| title_full | Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosis |
| title_fullStr | Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosis |
| title_full_unstemmed | Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosis |
| title_short | Activin receptor-like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating Smad2/3 signaling in diabetic atherosclerosis |
| title_sort | activin receptor like kinase 7 promotes apoptosis of vascular smooth muscle cells via activating smad2 3 signaling in diabetic atherosclerosis |
| topic | diabetic atherosclerosis activin receptor-like kinase 7 vascular smooth muscle cells apoptosis Smad2/3 |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.926433/full |
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